Abstract
Immune responses are in the beginning, specific in that a given lymphocyte is initially triggered via its membrane receptors for a specific antigen. But following the initial antigen trigger, a specific T lymphocyte elaborates a number of nonspecific soluble mediators with a wide range of effects on other cells, both proximal and distal, both within the immune system and outside it, A complex network develops in which these immune cytokines exert positive and negative feedback effects on one another. Immune cytokines include: interleukin 1 (produced by macrophages and other cells, with actions on many cell types), interleukin 2 (produced by T cells, with actions on T and B cells), interleukin 3 (produced by T cells, with actions on hematopoietic stem cells), interferon-γ (produced by T cells, with actions on many cell types), B cell stimulating factor or BSF 1 (produced by T cells, with actions on B and T cells), lymphotoxin (produced by T cells, actions on tumor cells and various normal cell types) and tumor necrosis factor also termed cachectin (produced by macrophages and various other cell types, with actions on fat cells, macrophages and other cells.
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© 1987 Plenum Press, New York
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Durum, S.K. (1987). Interleukins: An Overview. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_34
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DOI: https://doi.org/10.1007/978-1-4613-0919-2_34
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