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Immune Function and Severe Infection

  • Conference paper
Lipid Mediators in the Immunology of Shock

Part of the book series: NATO ASI Series ((NSSA,volume 139))

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Abstract

In patients with an acute bacterial infection such as meningococcal meningitis, lymphocyte proliferative responses in vitro are depressed soon after the onset of symptoms1. Responses to microbial antigens are more sensitive than the responses to mitogens such as phytohemagglutinin (PHA) and are as a rule completely suppressed during the acute stage. The response to suboptimal concentrations of PHA may be a more sensitive indicator of depressed lymphocyte function than when the usual dose is employed2.

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References

  1. V Andersen, NE Hansen, H Karle, I Lind, N Høiby, and B Weeke. Clin exp Immunol, 26: 469 (1976).

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  2. CS Hosking, MG Fitzgerald, and MJ Simons. Clin exp Immunol, 9: 467 (1971).

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  3. HH Mogensen and V Andersen. Acta path microbiol scand Sect C, 89: 365 (1981).

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  4. G Banck and A Forsgren. Scand J Immunol, 8: 347 (1978).

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  5. V Andersen, JB Hertz, SF Sørensen, P Bækgaard, PE Christensen, W Ramhøj, GA Hansen, AC Wardlaw, and Y Sato. Acta path microbiol scand Sect C, 85: 65 (1977).

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  6. H Effersoe, F Espersen, and V Andersen. Acta path microbiol scand Sect C, 92: 121 (1984).

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Author information

Authors and Affiliations

  1. Laboratory of Medical Immunology, Department of Medicine TTA Rigshospitalet, University Hospital, Copenhagen, Denmark

    V. Andersen

Authors
  1. V. Andersen
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Editor information

Editors and Affiliations

  1. Centre de Traitement des Brules, Hopital d’Instruction des Armees Percy, Clamart, France

    M. Paubert-Braquet

  2. Institut Henri Beaufour, Le Plessis-Robinson, France

    P. Braquet

  3. Longwood Area Trauma Center, Harvard Medical School, Boston, Massachusetts, USA

    B. Demling

  4. St. Thomas Hospital, Nashville, Tennessee, USA

    J. R. Fletcher

  5. Georgetown University Medical Center, Washington, D.C., USA

    M. Foegh

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© 1987 Plenum Press, New York

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Cite this paper

Andersen, V. (1987). Immune Function and Severe Infection. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_33

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  • DOI: https://doi.org/10.1007/978-1-4613-0919-2_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8245-7

  • Online ISBN: 978-1-4613-0919-2

  • eBook Packages: Springer Book Archive

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