Abstract
Bradykinin and related kinins have been shoun to produce all four of the cardinal signs of the inflammatory response, vasodilatation, increased vascular permeability, pain and, in higher doses, accumulation of leucocytes (1). Some observations have described the appearance of kinins in inflammatory exudates induced by thermal injury. Roche e Silva and Antonio (2) observed that immersing rat paw in hot water induced the appearance of a kinin-like activity in the perfusate of the subcutaneous spaces. This observation was confirmed several times by the same group (3, 4, 5). Edery and Lewis (6) detected a kinin-forming activity in the lymph draining the burned limb of the dog. Kinins could thus participate in the inflammatory response to burn.
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© 1987 Plenum Press, New York
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Damas, J., Adam, A., Marichi, J., Lecomte, J. (1987). Significance of the Activation of the Kinin System Following Thermal Injury. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_25
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DOI: https://doi.org/10.1007/978-1-4613-0919-2_25
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