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Biogenic Amines: Microcirculatory Aspects in Shock, Sepsis and Trauma

  • Conference paper
Lipid Mediators in the Immunology of Shock

Part of the book series: NATO ASI Series ((NSSA,volume 139))

Abstract

The purpose of this communication is to give a concise overview of the effect of shock, sepsis and trauma on the handling of biogenic amines in the body and also how these substances affect the organism exposed to these pathophysiologies. I will deal primarily with some of the microcirculatory phenomena and their mechanisms, and will not deal with the use of biogenic amines or their blockers in the therapy of these disorders. Further, I will consider only the monoamines, i.e. catecholamines (including epinephrine, norepinephrine and dopamine), serotonin (i.e.5-hydroxytryptamine) and histamine. To my knowledge, the effect of shock, sepsis and trauma on polyamines has not been studied. These substances are involved in cell differentiation and growth, and it is conceivable that disorders here could have long-term effects. For a review of these substances see Heby (1986). Since much more is known about the reactions of catecholamines than about serotonin and histamine, most emphasis will be placed on catecholamines.

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Author information

Authors and Affiliations

  1. Clinical Research Center, University Hospital, S-581 85, Linköping, Sweden

    D. H. Lewis

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  1. D. H. Lewis
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Editor information

Editors and Affiliations

  1. Centre de Traitement des Brules, Hopital d’Instruction des Armees Percy, Clamart, France

    M. Paubert-Braquet

  2. Institut Henri Beaufour, Le Plessis-Robinson, France

    P. Braquet

  3. Longwood Area Trauma Center, Harvard Medical School, Boston, Massachusetts, USA

    B. Demling

  4. St. Thomas Hospital, Nashville, Tennessee, USA

    J. R. Fletcher

  5. Georgetown University Medical Center, Washington, D.C., USA

    M. Foegh

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© 1987 Plenum Press, New York

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Lewis, D.H. (1987). Biogenic Amines: Microcirculatory Aspects in Shock, Sepsis and Trauma. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_23

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  • DOI: https://doi.org/10.1007/978-1-4613-0919-2_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8245-7

  • Online ISBN: 978-1-4613-0919-2

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