Abstract
Anaphylaxis in the guinea-pig is widely used as a model for human asthma. Nevertheless, no ultrastructural morphological studies of the anaphylactic shock in this animal were reported until now. Beside histamine, alternative mediators accounting for asthma have been incriminated, the peptido-leukotrienes first, and, more recently, PAF-acether was added to the list (Braquet et al, 1985; Page and Morley, 1986). This ether-linked phospholipid is known to induce various biological actions. It is also released during allergic reactions (Benveniste et al., 1972; Pinckard et al., 1979). PAF-acether administrated i.v. to the guinea-pig induces bronchoconstriction, which is histamine and cyclooxygenase-independent and platelet-dependent (Vargaftig et al., 1980). This is consistent with the fact that non-steroidal anti-inflammatory drugs are ineffective in clinical asthma.
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References
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Lellouch-Tubiana, A., Lefort, J., Lagente, V., Cirino, M., Vargaftig, M., Vargaftig, B.B. (1987). Morphological and Pharmacological Evidences for the Participation of PAF-Acether in Anaphylactic Shock in the Guinea-Pig. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_22
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DOI: https://doi.org/10.1007/978-1-4613-0919-2_22
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