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Mechanisms of Circulatory Collapse Induced by PAF-Acether

  • Conference paper
Lipid Mediators in the Immunology of Shock

Part of the book series: NATO ASI Series ((NSSA,volume 139))

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Abstract

PAF-acether (l-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) is an inflammatory mediator with potent circulatory actions (1). Release of this agent by activated leukocytes, macrophages, platelets, and thrombin-stimulated endothelial cells is likely to occur during Ig-E related anaphylaxis or sepsis. Adverse effects of PAF-acether may contribute significantly to circulatory deterioration and collapse that can accompany these conditions.

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Author information

Authors and Affiliations

  1. Divisions of Cardiology and Clinical Pharmacology and Neurobiology Research Unit, Departments of Medicine, Pharmacology, and Neurology, Uniformed Services University of Health Sciences Bethesda, 20814, Maryland, USA

    R. E. Goldstein, F. R. M. Laurindo, D. Ezra & G. Z. Feuerstein

Authors
  1. R. E. Goldstein
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  2. F. R. M. Laurindo
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  3. D. Ezra
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  4. G. Z. Feuerstein
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Editor information

Editors and Affiliations

  1. Centre de Traitement des Brules, Hopital d’Instruction des Armees Percy, Clamart, France

    M. Paubert-Braquet

  2. Institut Henri Beaufour, Le Plessis-Robinson, France

    P. Braquet

  3. Longwood Area Trauma Center, Harvard Medical School, Boston, Massachusetts, USA

    B. Demling

  4. St. Thomas Hospital, Nashville, Tennessee, USA

    J. R. Fletcher

  5. Georgetown University Medical Center, Washington, D.C., USA

    M. Foegh

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© 1987 Plenum Press, New York

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Goldstein, R.E., Laurindo, F.R.M., Ezra, D., Feuerstein, G.Z. (1987). Mechanisms of Circulatory Collapse Induced by PAF-Acether. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_19

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  • DOI: https://doi.org/10.1007/978-1-4613-0919-2_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8245-7

  • Online ISBN: 978-1-4613-0919-2

  • eBook Packages: Springer Book Archive

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