Receptor Binding Techniques in Neurotoxicology

  • Lucio G. Costa
  • Marina Marinovich
  • Corrado L. Galli
Part of the NATO ASI Series book series (NSSA, volume 100)


This chapter is intended to be an overview on receptor binding techniques and their application to the study of the neurotoxicity of chemicals. Although the theoretical basis of radioligand binding assays, the experimental methodologies and the basic processes of interpretation of binding data will be briefly considered, the reader is referred to other publications for more detailed theoretical and practical reviews (Peck and Kelner, 1983; Yamamura et al., 1978; Titeler, 1981; Williams and Lefkowitz, 1978). A few reviews on the use of radioligand techniques in neurotoxicology have also been recently published (Bondy, 1979; 1982; DeHaven and Mailman, 1983).


Receptor Binding Muscarinic Receptor Neurotransmitter Receptor Scatchard Plot Radioreceptor Assay 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Lucio G. Costa
    • 1
  • Marina Marinovich
    • 2
  • Corrado L. Galli
    • 2
  1. 1.Department of Environmental HealthUniversity of WashingtonSeattleWashingtonUSA
  2. 2.Laboratory of ToxicologyInstitute of Pharmacology and Pharmacognosy, University of MilanoMilanoItaly

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