Collagen Biosynthesis

  • Bjorn Reino Olsen


The biosynthesis of the collagen component of connective tissues involves the regulated expression of gene members of the large collagen gene family (Chapter 1) as well as complex interactions between primary collagen translation products and several cotranslational and posttranslational modifying enzymes (for review, see Bornstein and Traub, 1979). Although the total number of genes that code for collagen polypeptides has not yet been established, it is probably between 10 and 20. Nothing is known about the linkage between the different genes in the family, but it is likely that they evolved by duplication and divergence of a small ancestral gene (Ohkubo et al., 1980; Yamada et al., 1980).


Rough Endoplasmic Reticulum Collagen Gene Triple Helix Prolyl Hydroxylase Collagen Biosynthesis 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Bjorn Reino Olsen
    • 1
  1. 1.Department of PathologyCollege of Medicine and Dentistry of New Jersey-Rutgers Medical SchoolPiscatawayUSA

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