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Cell Biology of Extracellular Matrix pp 139–177Cite as

Collagen Biosynthesis

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Abstract

The biosynthesis of the collagen component of connective tissues involves the regulated expression of gene members of the large collagen gene family (Chapter 1) as well as complex interactions between primary collagen translation products and several cotranslational and posttranslational modifying enzymes (for review, see Bornstein and Traub, 1979). Although the total number of genes that code for collagen polypeptides has not yet been established, it is probably between 10 and 20. Nothing is known about the linkage between the different genes in the family, but it is likely that they evolved by duplication and divergence of a small ancestral gene (Ohkubo et al., 1980; Yamada et al., 1980).

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  1. Department of Pathology, College of Medicine and Dentistry of New Jersey-Rutgers Medical School, Piscataway, New Jersey, 08854, USA

    Bjorn Reino Olsen

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  1. Bjorn Reino Olsen
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  1. Department of Anatomy, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Elizabeth D. Hay

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© 1981 Plenum Press, New York

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Olsen, B.R. (1981). Collagen Biosynthesis. In: Hay, E.D. (eds) Cell Biology of Extracellular Matrix. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0881-2_7

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  • DOI: https://doi.org/10.1007/978-1-4613-0881-2_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8226-6

  • Online ISBN: 978-1-4613-0881-2

  • eBook Packages: Springer Book Archive

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