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Proteoglycan Biosynthesis

  • Chapter
Cell Biology of Extracellular Matrix

Abstract

Proteoglycans of cartilage are glycoproteins that contain a protein core to which are attached large numbers of two types of glycosaminoglycan chains and a smaller number of mannose-containing oligosaccharides. Current concepts of the structure of the proteoglycan molecule are discussed in Chapter 2 of this volume and have been reviewed elsewhere (Hascall and HeinegÄrd, 1979). The discussion in Chapter 2 makes it clear that although great progress has been made in the elucidation of the structure of cartilage chondroitin sulfate proteoglycan (CSPG), important questions remain, some of which must be resolved before a complete understanding of biosynthesis will become possible. Nevertheless, studies on biosynthesis have made considerable progress and may, in turn, contribute to the understanding of both structure and function.

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Authors and Affiliations

  1. Department of Pediatrics and Biochemistry, Joseph P. Kennedy Jr. Mental Retardation Research Center, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, 60637, USA

    Albert Dorfman

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  1. Department of Anatomy, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Elizabeth D. Hay

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© 1981 Plenum Press, New York

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Dorfman, A. (1981). Proteoglycan Biosynthesis. In: Hay, E.D. (eds) Cell Biology of Extracellular Matrix. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0881-2_6

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  • DOI: https://doi.org/10.1007/978-1-4613-0881-2_6

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