Control of the Coronary Circulation

  • Harvey V. SparksJr
  • Roger D. Wangler
  • Mark W. Gorman
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 90)


Normal function of the heart depends on an adequate coronary blood flow. Myocardial metabolism and coronary flow are mutually interactive so that any increase in the metabolism of the normal heart is matched by an increase in coronary blood flow, and any significant restriction of flow results in the reduction of myocardial metabolism and cardiac performance.In this chapter we discuss the determinants of coronary blood flow, which include myocardial metabolism, humoral influences, and neural control.We will not discuss the role of physical factors in determining coronary blood flow because that is the subject of the chapter by Dr. Downey.In adddtion, we discuss certain pathophysiologic conditions, such as vascular responses to cardiac hypertrophy and myocardial ischemia, and the significance of coronary collateral vessels.


Left Ventricular Hypertrophy Cardiac Hypertrophy Myocardial Blood Flow Coronary Blood Flow Adenosine Deaminase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Berne RM,Rubio R:Coronary circulation.In: Berne RM, Sperelakis N, Geiger SR (eds) Handbook of Physiology. Vol 1. Section 2: The Cardiovascular System. Besthesda: American Physiological Society, 1979, pp 873–952Google Scholar
  2. 2.
    Harlan DM, Rooke TW, Belloni FL, Sparks HV: Effect of indomethacin on coronary vascular response to increased myocardial oxygen consumption. Am J Physiol 235: H372–H378, 1978.PubMedGoogle Scholar
  3. 3.
    Coffman JD, Gregg DE: Reactive hyperemia characteristics of the myocardium. Am J Physiol 199: 1143–1149, I960.Google Scholar
  4. 4.
    Khouri EM, Gregg ED, Lowensohn HS: Flow in the major branches of the left coronary artery during experimental coronary insufficiency in the anesthetized dog. Circ Res 23: 99–109, 1968.PubMedGoogle Scholar
  5. 5.
    Olsson RA, Gregg DE: Myocardial reactive hyperemia in the unanesthetized dog. Am J Physiol 208: 224–230, 1965.PubMedGoogle Scholar
  6. 6.
    Johnson PC: The myogenic response. In: Bohr DF, Somlyo SR, Sparks HV (eds) Handbook of Physiology. Vol 2. Section 2: The Cardiovascular System. Bethesda: American Physiological Society, 1980, pp 409–442.Google Scholar
  7. 7.
    Eikens E, Wikken DEL: Myocardial reactive hyperemia and coronary vascular reactivity in the dog. Circ Res 33: 267–274, 1973.PubMedGoogle Scholar
  8. 8.
    Eikens E, Wikken DEL: Reactive hyperemia in the dog heart: Effects of temporarily restricting arterial inflow and of coronary occlusions lasting one and two cardiac cycle. Circ Res 35: 702–712, 1974.PubMedGoogle Scholar
  9. 9.
    Schwartz GG, McHale PA, Greenfield JG: Hypere-mic response of the coronary circulation to brief diastolic occlusion in the conscious dog. Circ Res 50: 28–37, 1982.PubMedGoogle Scholar
  10. 10.
    Scott JB, Radawski D: Role of hyperosmolarity in the genesis of active and reactive hyperemia. Circ Res (Suppl 1) 28: 126–32, 1971.Google Scholar
  11. 11.
    Murray PA, Belloni FL, Sparks HV: The role of potassium in the metabolic control of coronary vascular resistance of the dog. Circ Res 44: 767–780, 1979.PubMedGoogle Scholar
  12. 12.
    Bunger R, Haddy FJ, Querengasser A, Gerlach E: Studies on potassium induced coronary dilation in the isolated guinea pig heart. Pflügers Arch 63: 27–31, 1976.Google Scholar
  13. 13.
    winbury MM, Howe BB, Weiss HR: Effect of nitroglycerin and dipyridamole on epicardial and endocardial oxygen tension: Further evidence for redistribution of myocardial blood flow. J Pharmacol Exp Ther 176: 184–199, 1971.PubMedGoogle Scholar
  14. 14.
    Sparks HV: Effect of local metabolic factors on vascular smooth muscle. In: Bohr DF, Somlyo SR, Sparks HV (eds) Handbook of Physiology. Vol 2. Section 2: The Cardiovascular System. Bethesda: American Physiological Society, 1980, pp 475–513Google Scholar
  15. 15.
    Chang AE, Detar R: Oxygen and vascular smooth muscle revisited. Am J Physiol 238: H716–H728, 1980.PubMedGoogle Scholar
  16. 16.
    Coburn RF, Polegmakers F, Gondrie P, Abboud R: Myocardial myoglobin oxygen tension. Am J Physiol 224: 870–876, 1973.PubMedGoogle Scholar
  17. 17.
    Kalsner S: Intrinsic prostaglandin release: A mediator of anoxia-induced relaxation in an isolated coronary artery preparation. Blood Vessels 13: 155–166, 1976.PubMedGoogle Scholar
  18. 18.
    McNeil TA: Venous oxygen saturation and blood flow during reactive hyperemia in the human forearm. J Physiol (Lond) 134: 195–201, 1956.Google Scholar
  19. 19.
    Alexander RW, Kent KM, Pisano JJ, Keiser HR, Cooper T: Regulation of postocclusive hyperemia by endogenously synthesized prostaglandins in the dog heart. J Clin Invest 55: 1174–1181, 1975.PubMedGoogle Scholar
  20. 20.
    Needleman P, Iskoson PC: Intrinsic prostaglandin biosynthesis in blood vessels. In: Bohr DF, Somlyo SR, Sparks HV (eds) Handbook of Physiology. Vol 2, Section 2: The Cardiovascular System. Bethesda, MD: American Physiological Society, 1980, p 613–633.Google Scholar
  21. 21.
    Owen TL, Ehrhart IC, Weidner WJ, Scott JB, Haddy FJ: Effects of indomethacin on local blood flow regulation in canine heart and kidney. Proc Soc Exp Biol Med 149: 871–876, 1975.PubMedGoogle Scholar
  22. 22.
    Hintze TH, Kaley G: Prostaglandins and the control of blood flow in the canine myocardium. Circ Res 40: 313–320, 1977.PubMedGoogle Scholar
  23. 23.
    Giles RW, Wikken DEL: Reactive hyperemia in the dog heart: Inter-relations between adenosine, ATP, and aminophylline and the effect of indomethacin. Cardiovas Res 11: 113–121, 1977.Google Scholar
  24. 24.
    Rubio R, Berne RM, Katori M: Release of adenosine in reactive hyperemia of the dog heart. Am J Physiol 216: 56–62, 1969.PubMedGoogle Scholar
  25. 25.
    Olsson RA: Changes in content of purine nucleoside in canine myocardium during coronary occlusion. Circ Res 26: 301–306, 1970.PubMedGoogle Scholar
  26. 26.
    Schräder J, Haddy FJ, Gerlach E: Release of adenosine, inosine, and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregula-tion and reactive hyperemia. Pflügers Arch 369: 1–6, 1977.PubMedGoogle Scholar
  27. 27.
    Olsson RA, Snow JA, Gentry MK: Adenosine metabolism in canine myocardial reactive hyperemia. Circ Res 42: 358–362, 1978.PubMedGoogle Scholar
  28. 28.
    Curnish RR, Berne RM, Rubio R: Effect of aminophylline on myocardial reactive hyetemia. Proc Soc Exp Biol Med 141:593–598, 1972.PubMedGoogle Scholar
  29. 29.
    Schutz W, Zimpfer M, Raberger G: Effect of aminophylline on coronary reactive hyperemia following brief and long occlusion periods. Cardiovasc Res 11: 507–511, 1977.PubMedGoogle Scholar
  30. 30.
    Juhran W, Voss EM, Dietmann K, Schaumann W: Pharmacologic effects on coronary reactive hyperemia in conscious dogs. Naunyn-Schmiedbergs Arch Pharmacol 269: 32–47, 1971.Google Scholar
  31. 31.
    Bittar N, Pauly TJ: Myocardial reactive hyperemia responses in the dog after aminophylline and lido-flazine. Am J Physiol 220: 812–815, 1971.PubMedGoogle Scholar
  32. 32.
    Saito D, Seinhart CR, Nixon DG, Olsson RA: Intracoronary adenosine deaminase reduces canine myocardial reactive hyperemia. Circ Re& 49: 1262–1267, 1981.Google Scholar
  33. 33.
    Haddy FJ, Scott JB: Metabolic factors in peripheral circulatory regulation. Fed Proc: 2006–2011, 1975.Google Scholar
  34. 34.
    Mosher P, Ross J, McFate PA, Shaw RF: Control of coronary blood flow by an autoregulatory mechanism. Circ Res 14: 250–259, 1964.PubMedGoogle Scholar
  35. 35.
    Shaw RF, Mosher P, Ross J, Joseph JI, Lee ASJ: Physiologic principles of coronary perfusion. J Thorac Cardiovas Surg 44: 608–616, 1962.Google Scholar
  36. 36.
    Rouleau J, Boerboom LE, Surjadhana A, Hoffman JIE: The role of autoregulation and tissue diastolic pressures in the transmural distribution of left ventricular blood flow in anesthetized dogs. Circ Res 45: 804–815, 1979.PubMedGoogle Scholar
  37. 37.
    Boatwright RB, Downey HF, Bashour FA, Crystal GJ: Transmural variation in autoregulation of coronary blood flow in hyperperfused canine myocardium. Circ Res 47: 599–609, 1980.PubMedGoogle Scholar
  38. 38.
    Rubio R, Berne RM: Regulation of coronary blood flow. Prog Cardiovasc Dis 18: 105–122, 1975.PubMedGoogle Scholar
  39. 39.
    Mohrman DE, Feigel EO: Competition between sympathetic vasoconstriction and metabolic vasodilation in the canine coronary circulation. Circ Res 42: 79–86, 1977.Google Scholar
  40. 40.
    Britton S, Di Valvo J: Effects of angiotensin I and angiotensin II on hindlimb and coronary vascular resistance. Am J Physiol 225: 1226–1231, 1973.PubMedGoogle Scholar
  41. 41.
    Cohen MV, Kirk ES: Differential response of large and small coronary arteries to nitroglycerin and angiotensin: Autoregulation and tachyphylaxis. Circ Res 33: 445–453, 1973.PubMedGoogle Scholar
  42. 42.
    Green HD, Kepchar JH: control of peripheral resistance in major systemic vascular beds. Physiol Rev 39: 617–686, 1959.PubMedGoogle Scholar
  43. 43.
    Case RB, Felix A, Wachter M, Kyriakidis G, Cas-tellana F: Relative effect of C02 on canine coronary vascular resistance. Circ Res 42: 410–418, 1978.PubMedGoogle Scholar
  44. 44.
    Case RB, Greenberg H: The response of canine coronary vascular resistance to local alterations in coronary arterial pco2- Circ Res 39: 558–566, 1976.PubMedGoogle Scholar
  45. 45.
    Case RB, Greenberg H, Moskowitz R: Alterations in coronary sinus po2 and 02 saturation resulting from Pco2 changes. Cardiovasc Res 9: 167–177, 1975.PubMedGoogle Scholar
  46. 46.
    Rooke, T, Sparks HV: Arterial C02, myocardial 02 consumption, and coronary blood flow in the dog. Circ Res 47: 217–225, 1980.PubMedGoogle Scholar
  47. 47.
    Wiedmeier VT, Spell LH: Effects of catecholamines, histamine and nitroglycerin on flow, oxygen consumption and coronary blood flow during stellate ganglia stimulation. Circ Res 45: 708–718, 1979.Google Scholar
  48. 48.
    Raberger G, Weissei M, Kraupp O: The dependence of the effects of intracoronary administered adenosine and of coronary conductance on the artetial pH, Pco2, and buffer capacity in dogs. Naunyn-Schmiedebergs Arch Pharmacol 271: 301–310, 1971Google Scholar
  49. 49.
    Merrill GF, Haddy FJ, Dabney JM: Adenosine, theophylline, and perfusate pH in the isolated, perfused guinea pig heart. Circ Res 42: 225–229, 1978PubMedGoogle Scholar
  50. 50.
    Kittle CF, Aoki H, Brown E: The role of pH and C02 in the distribution of blood flow. Surgery 57: 139–154, 1965.PubMedGoogle Scholar
  51. 51.
    Tarnow J, Bruckner JB, Eberlein HJ, Gethmann JW, Hess W, Patschke D, Wilde J: Blood pH and Paco2 as chemical factors in myocardial blood flow control. Basic Res Cardiol 70: 685–696, 1975.PubMedGoogle Scholar
  52. 52.
    Gilmore JP, Nizolek JA, Jacob RJ: Further characterization of myocardial K+ loss induced by changing contraction frequency. Am J Physiol 221: 465–69, 1971.PubMedGoogle Scholar
  53. 53.
    Sybers HD, Helmer RP, Murphy QR: Effects of hypoxia on myocardial potassium balance. Am J Physiol 220: 2047–2050, 1971.PubMedGoogle Scholar
  54. 54.
    Frick GP, Lowenstein JM: Studies of 5’-nucleotidase in the perfused rat heart: Including measurements of the enzyme in perfused skeletal muscle and liver. J Biol Chem 251: 6372–6378, 1976.PubMedGoogle Scholar
  55. 55.
    Schutz W, Shrader J, Gerlach E: Different sites of adenosine formation in the heart. Am J Physiol 240: H963–H970, 1981.PubMedGoogle Scholar
  56. 56.
    Schrader J, Schutz W, Bardenheuer H: Role of S-adenosylhomocysteine hydrolase in adenosine metabolism in mammalian heart. Biochem J 196: 65–70, 1981.PubMedGoogle Scholar
  57. 57.
    Olsson RA, Saito D, Steinhart CR: Compartmentalization of the adenosine pool of dog and rat hearts. Circ Res 50: 617–626, 1982PubMedGoogle Scholar
  58. 58.
    Schräder J, Gerlach E: Compartmentation of cardiac adenine nucleotides and formation of adenosine. Pflügers Arch 367: 129–135, 1976.PubMedGoogle Scholar
  59. 59.
    Belloni FL, Rubio R, Berne RM: Intracellular adenosine in isolated rat liver cells. Pflügers Arch 400: 106–108, 1984.PubMedGoogle Scholar
  60. 60.
    Miller WL, Belardinelli L, Bacchus A, Foley DH, Rubio R, Berne RM: Canine myocardial adenosine and lactate production, oxygen consumption and coronary blood flow during stellate ganglia stimulation. Circ Res 45: 708–718, 1979.PubMedGoogle Scholar
  61. 61.
    Watkinson WP, Foley DH, Rubio R, Berne RM: Myocardial adenosine formation with increased cardiac performance in the dog. Am J Physiol 236: H13–H21, 1979.PubMedGoogle Scholar
  62. 62.
    Knabb RM, Ely SW, Bacchus AN, Rubio R, Berne RM: Consistent parallel relationships among myo-cardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta blockade in the dog.Circ Res 53: 33–41, 1983.PubMedGoogle Scholar
  63. 63.
    Degenring FH: Cardiac nucleotides and coronary flow during changes of cardiac inotropy. Basic Res Cardiol 71: 291–296, 1976.Google Scholar
  64. 64.
    Foley DH, Herlihy JT, Thompson CI, Rubio R, Berne RM: Increased adenosine formation by rat myocardium with acute aortic constriction. J Mol Cell Cardiol 10: 293–300, 1978.PubMedGoogle Scholar
  65. 65.
    McKenzie JE, McCoy FP, Bockman EL: Myocardial adenosine and coronary resistance during increased cardiac performance. Am J Physiol 239: H509–515, 1980.PubMedGoogle Scholar
  66. 66.
    Jones CE, Hurst TW, Randall JR: Effect of amino-phylline on coronary funtionaly hyperemia and myocardial adenosine. Am J Physiol 243: H480–H487, 1982.PubMedGoogle Scholar
  67. 67.
    Manfredi JP, Sparks HV: Adenosine’s role in coronary vasodilation induced by atrial pacing and norepinephrine. Am J Physiol 243: H536–H545, 1982.PubMedGoogle Scholar
  68. 68.
    DeWitt DF, Wangler RD, Thompson CI, Sparks HV: Phasic release of adenosine during steady state metabolic stimulation in the isolated guinea pig heart. Circ Res 53: 636–643, 1983.PubMedGoogle Scholar
  69. 69.
    McKenzie JE, Steffan RP, Price RB, Haddy FJ: Effect of theophylline on adenosine and coronary vascular resistance during increased cardiac work. Physiologist 24: 26, 1981.Google Scholar
  70. 70.
    Nees S, Gerbes AL, Willershausen-Zonnchen B, Gerlach E: Purine metabolism in cultured endothelial cells. Adv Exp Med Biol 122: 25–30, 1980.Google Scholar
  71. 71.
    Weiss HR: Effect of coronary artery occlusion in regional arterial and venous O2 saturation, 02 extraction, blood flow, and O2 consumption in the dog heart. Circ Res 47: 400–407, 1980.PubMedGoogle Scholar
  72. 72.
    Busse R, Pohl V, Kellner C, Klenim V: Endothelial cells are involved in the vasodilatory response to hyoxia. Pflügers Arch 397: 78–80, 1983.PubMedGoogle Scholar
  73. 73.
    Hintze TH, Vatner SF: Reactive dilation of large coronary arteries in conscious dogs. Circ Res 54: 50–57, 1984.PubMedGoogle Scholar
  74. 74.
    Dole WP, Nuno DW: Myocardial oxygen tension determines the degree and pressure range of coronary autoregulation. Circ Res 59: 202–215, 1986.PubMedGoogle Scholar
  75. 75.
    Sparks HV, Gorman MW: Adenosine in the local regulation of blood flow: Current controversies. In: Gerlach E, Schräder J, Berne R (eds) Proceedings of the 3rd International Symposium on Adenosine. In press.Google Scholar
  76. 76.
    Lowenstein JM, Yu MK, Naito Y: Regulation of adenosine metabolism by 5’-nucleotidase. In: Berne RM, Rail TW, Rubio R (eds) Regulatory Function of Adenosine. Boston: Martinus Nijhoff, 1983, pp 117–129.Google Scholar
  77. 77.
    Dole WP, Yamada N, Bishop VS, Olsson RA: Role of adenosine in coronary blood flow regulation after reductions in perfusion pressure. Circ Res 56: 517–524, 1985.PubMedGoogle Scholar
  78. 78.
    Kroll K, Feigl EO: Adenosine is unimportant in controlling coronary blood flow in unstressed dog hearts. Am J Physiol 249: H1176–H1187, 1985.PubMedGoogle Scholar
  79. 79.
    Merrill GF, Jones CE, Downey HF: Adenosine deaminase attenuates norepinephrine-induced coronary functional hyperemia (abstr). Physiologist 28: 340, 1985.Google Scholar
  80. 80.
    Nees S, Gerlach E: Adenine nucleotide and adenosine metabolism in cultured coronary endothelial cells: Formation and release of adenine compounds and possible functional implications. In: Berne RM, Rail TW, Rubio R (eds) Regulatory Function of Adenosine. Boston: Martinus Nijhoff, 1983, pp 347–355.Google Scholar
  81. 81.
    Kroll K, Schrader JS: Quantification of adenosine release from coronary endothelial cells in guinea pig hearts (abstr). Pflügers Archiv 405: RH, 1985.Google Scholar
  82. 82.
    Burnstock G: Purinergic nerves. Pharmacol Rev 24: 509–581, 1972.PubMedGoogle Scholar
  83. 83.
    Pearson JD, Carlton JS, Gordon JL: Metabolism of adenine nucleotides by ectoenzymes of vascular eno-thelial and smooth muscle cells in culture. Biochem J 190: 421–429, 1980.PubMedGoogle Scholar
  84. 84.
    Fredholm BB, Hedquivist P, Lindstrom K, Wenn-malm M: Release of nucleosides and nucleotides from rabbit heart by sympathetic nerve stimulation. Acta Physiol Scand 116: 285–295, 1982.PubMedGoogle Scholar
  85. 85.
    Sparks HV, Bardenheuer H: Regulation of adenosine formation by the heart. Circ Res 58: 193–201, 1986.PubMedGoogle Scholar
  86. 86.
    Barenheuer H, Schrader J: Relationship between myocardial oxygen consumption, coronary flow and adenosine release in the improved isolated working heart preparation of guinea pigs. Circ Res 51: 263–271, 1983.Google Scholar
  87. 87.
    Bardenheuer H, Whelton B, Sparks HV: Adenosine release by in situ endothelial cells. In: Yudilevich DL, Mann GE (eds) Catrier Mediated Ttansport of Solutes From Blood to Tissue. New York: Longman, 1985, pp 205–211.Google Scholar
  88. 88.
    Pohl V, Holtz J, Busse R, Bassenge E: Ctucial role of endothelium in the vasodilator response to in-creased flow in vivo. Hypertension 8: 37–44, 1986.PubMedGoogle Scholar
  89. 89.
    Kaiser L, Sparks HV: Mediation of flow dependent artetial dilation by endothelial cells. Circulatory Shock 18: 109–114, 1986.PubMedGoogle Scholar
  90. 90.
    Randall WC, Armour JA: Gross and microscropic anatomy of the cardiac innervation. In: Randall WC (ed) Neural Regulation of the Heart. New York: Oxford University, 1977, pp 13–41.Google Scholar
  91. 91.
    Armour JA, Randall WC: Functional anatomy of canine cardiac fibers. Acta Anat 91: 510–528, 1975.PubMedGoogle Scholar
  92. 92.
    Denn MJ, Stone HL: Autonomic innervation of dog coronary arteries. J Appl Physiol 41: 30–35, 1976.PubMedGoogle Scholar
  93. 93.
    Dolezel S, Gerova J, Gero J, Sladek T, Vasku J: Adrenergic innervation of the coronary arteries and the myocardium. Acta Anat 100: 306–316, 1978.PubMedGoogle Scholar
  94. 94.
    Schenk EA, Badawi AE: Dual innervation of arteries and arterioles: Histochemical study. Z Zellforsch Mikrosk Anat 91: 170–177, 1968.PubMedGoogle Scholar
  95. 95.
    McRaven DR, Mark AL, Abboud FM, Mayer HE: Responses of coronary vessels to adtenetgic stimuli. J Clin Invest 50: 773–778, 1971.PubMedGoogle Scholar
  96. 96.
    Ek L, Ablad B: Effects of three beta adrenergic receptor blockers on myocardial oxygen consumption in the dog. Eur J Pharmacol 14: 19–28, 1971.PubMedGoogle Scholar
  97. 97.
    Uchida Y, Murao S: Sustained decrease in coronary blood flow and excitation of cardiac sensory fibers following sympathetic stimulation. Jpn Heatt J 16: 265–279, 1975.Google Scholar
  98. 98.
    Mark AL, Abboud FM, Schmid PG, Heistad DD, Mayer HE: Differences in direct effects of adrenergic stimuli on coronary, cutaneous and muscular vessels. J Clin Invest 51: 279–287, 1972.PubMedGoogle Scholar
  99. 99.
    Hamilton FN, Feigl EO: Cotonary vascular sympathetic beta receptor innervation. Am J Physiol 230: 1569–1576, 1976.PubMedGoogle Scholar
  100. 100.
    Imai S, Otorii T, Takeda K, Katano Y: Coronary vasodilation and adrenergic receptors in the dog heart and coronary. Jpn J Pharmacol 25: 423–432, 1975.PubMedGoogle Scholar
  101. 101.
    Murray PA, Vatner SF: Adrenoreceptor attenuation of the coronary vascular response to severe exercise in the conscious dog. Circ Res 45: 654–660, 1979.PubMedGoogle Scholar
  102. 102.
    Heydrickx GR, Muylaert P, Pannier JL: Alpha adrenergic control of oxygen delivery to myocardium during exercise in conscious dogs. Am J Physiol 242: H805–H809, 1982.Google Scholar
  103. 103.
    Feigl EO: Control of myocardial oxygen tension by sympathetic cotonary vasoconstriction in the dog. Cite Res 37: 88–95, 1975.Google Scholar
  104. 104.
    Powell JR, Feigl EO: Carotid sinus teflex coronary vasoconstriction during controlled myocardial oxygen metabolism in the dog. Circ Res 44: 44–51, 1979.PubMedGoogle Scholar
  105. 105.
    Buffington CW, Feigl EO: Adrenergc coronary vasoconstriction in the presence of coronary stenosis in the dog. Circ Res 48: 416–423, 1981.PubMedGoogle Scholar
  106. 106.
    Yasue H, Touyama M, Shimamoto M, Kato H, Tanaka S, Akiyama F: Role of autonomic nervous system in the pathogenesis of Prinzmetal’s variant form of angina. Circulation 50: 534–539, 1974.PubMedGoogle Scholar
  107. 107.
    Yasue H, Touyama M, Kato H, Tanaka S, Akiyama F: Prinzmetal’s variant form of angina as a manifestation of alpha adrenergic receptor-mediated coronary artery spasm: Documentation by coronary arteriography. Am Heart J 91: 148–155, 1976.PubMedGoogle Scholar
  108. 108.
    Levene DL, Freeman MR: Alpha adrenergic mediated coronary artery spasm. JAMA 236: 1018–1022, 1976.PubMedGoogle Scholar
  109. 109.
    Hillis LD, Braunwald E: Coronary artery spasm. N Engl J Med 299: 695–702, 1978.PubMedGoogle Scholar
  110. 110.
    Zuberbuhler RC, Bohr DF: Responses of coronary smooth muscle to catecholamines. Circ Res 16: 431–440, 1965.PubMedGoogle Scholar
  111. 111.
    Mekata H, Niu H: Electrical and mechanical responses of coronary artery smooth muscle to catecholamines. Jpn J Physiol 19: 599–608, 1969.PubMedGoogle Scholar
  112. 112.
    Andersson R, Holmberg S, Svedmyr N, Aberg G: Adrenergic alpha and beta teceptors in coronary vessels in man: an in vitro study, acta Med Scand 191: 241–244, 1972.Google Scholar
  113. 113.
    Bayer B-L, Mentz P, Forster W:Characterization of the adrenoceptors in coronary arteries of pigs. Eur J Pharmacol 29: 58–69, 1974.PubMedGoogle Scholar
  114. 114.
    Feigl EO: Parasympathetic control of coronary blood flow in dogs. Circ Res 15: 509–519, 1969.Google Scholar
  115. 115.
    Tiedt N, Religa A: Vagal control of coronary blood flow in dogs. Basic Res Cardiol 74: 267–276, 1979.Google Scholar
  116. 116.
    Feigl EO: Sympathetic control of coronary circulation. Circ Res 20: 262–271, 1967.PubMedGoogle Scholar
  117. 117.
    Brown AM: Motor innervation of the coronary arteries of the cat. J Physiol (Lond) 198: 311–328, 1968.PubMedGoogle Scholar
  118. 118.
    Feigl EO: Carotid sinus reflex control of coronary blood flow. Circ Res 23: 262–271, 1968.Google Scholar
  119. 119.
    Vatner SF, Franklin D, Van Critters RL, Braunwald E: Effects of carotid sinus nerve stimulation on the coronary circulation of the conscious dog. Circ Res 27: 11–21, 1970.PubMedGoogle Scholar
  120. 120.
    Hackett JG, Abboud FM, Mark AL, Schmid PG, Heistad DD: Coronary vascular responses to stimulation of chemoreceptots and baroreceptors: Evidence for reflex activation of vagal cholinergic innervation. Circ Res 31: 8–17, 1972.PubMedGoogle Scholar
  121. 121.
    Religa Z, Trzebski A, Religa A, Glowienko A: Effect of the stimulation of afferent fibets in Hering’s nerve on the blood flow and resistance in the coronary vessels of the dogs. Pol Med J 11: 632–641, 1972.PubMedGoogle Scholar
  122. 122.
    Hashimoto K, Igakashi S, Uei I, Kumakuta S: Carotid chemoteceptor reflex effects on coronary flow and heart rate. Am J Physiol 206: 536–540, 1964.PubMedGoogle Scholar
  123. 123.
    Vatner SF, McRitchie RJ: Interaction of the chemo-reflex and the pulmonary inflation reflex in the regulation of coronary circulation in conscious dogs. Circ Res 37: 664–673, 1975.PubMedGoogle Scholar
  124. 124.
    Moreland R, Bohr DF: Adrenergic control of coronary arteries. Fed Proc 43: 2857–2861, 1984.PubMedGoogle Scholar
  125. 125.
    Cohn RA, Shepherd JT, Vanhoutte PM: Effects of the adrenergic transmitter on epicardial coronary arteries. Fed Proc 43: 2862–2866, 1984.Google Scholar
  126. 126.
    Gerwirtz RA, Stone HL: Coronary blood flow and myocardial oxygen consumption after alpha adrenergic blockade during submaximal exercise. J Pharmacol Exp Therap 217: 92–98, 1981.Google Scholar
  127. 127.
    Ito BR, Feigl EO: Carotid chemoreceptor reflex parasympathetic coronary vasodilation in the dog. Am J Physiol 249: H1167–H1175, 1985.PubMedGoogle Scholar
  128. 128.
    Murray PA, Lavallee M, Vatner SF: Alpha adrenergic mediated reduction in coronary blood flow secondary to carotid chemoreceptor reflex activation in conscious dogs. Circ Res 54: 96–106, 1984.PubMedGoogle Scholar
  129. 129.
    Ito BR, Feigl EO: Carotid baroreceptor reflex coronary vasodilation in the dog. Circ Res 56: 486–495, 1985.PubMedGoogle Scholar
  130. 130.
    Vatner SF: Alpha adrenergic tone in the coronary circulation of the conscious dog. Fed Proc 43: 2867–2872, 1985.Google Scholar
  131. 131.
    Holtz J, Mayer E, Bassenge E: Demonstration of alpha adrenergic coronary control in different layers of the canine myocardium by regional myocardial sympathectomy. Pflügers Arch 372: 187–194, 1977.PubMedGoogle Scholar
  132. 132.
    Chilian WM, Boatwright RB, Shoji T, Griggs DM: Evidence against significant resting sympathetic coronary vasoconstrictcor tone in the conscious dog. Circ Res 49: 866–876, 1981.PubMedGoogle Scholar
  133. 133.
    Buffington CW, Feigl EO: Effect of coronary artery pressure on transmural distribution of adrenergic coronary vasoconstriction in the dog. Circ Res 53: 613–621, 1983.PubMedGoogle Scholar
  134. 134.
    Kelley KO, Feigl EO: Segmental alpha receptor-mediated vasoconstriction in the canine coronary circulation. Circ Res 43: 908–916, 1978.PubMedGoogle Scholar
  135. 135.
    Johannsen UJ, Mark AL, Marcus ML: Responsiveness to cardiac sympathetic nerve stimulation during maximal coronary dilation produced by adenosine. Circ Res 50: 510–517, 1982.PubMedGoogle Scholar
  136. 136.
    Chilian WMK, Harrison DG, Haws CW, Snyder WD, Marcus ML: Adrenergic coronary tone during submaximal exercise in the dog is produced by circulating catecholamines: Evidence for adrenergic denervation supersensitivity in the myocardium but not in coronary vessels. Circ Res 58: 68–82, 1986.PubMedGoogle Scholar
  137. 137.
    Maseri A, L’Abbate A, Baroldi G, Chierchia M, Marzilli M, Ballestra Am, Severi S, Parodi O, Biagini A, Distante A, Pesola A: Coronary vasospasm as a possible cause of myocardial infarction. A conclusion derived from a study of “pre-infarction” angina. N Engl J Med 299: 1271–1277, 1978.PubMedGoogle Scholar
  138. 138.
    Mudge GH Jr,; Grossman W, Mills RM Jr, Lesch M, Brawnwald E: Reflex increase in coronary vascular resistance in patients with ischemic heart disease. N Engl J Med 295: 1333–1337, 1976.Google Scholar
  139. 139.
    Mudge GH Jr, Goldberg S, Gunther S, Mann T, Grossman W: Comparison of metabolic and vasoconstrictor stimuli on coronary vascular resistance in man. Circulation 59: 544–550, 1979PubMedGoogle Scholar
  140. 140.
    Malacoff RF, Mudge GH Jr, Holman BL, Idoine J, Bifolck L, Cohn PF: Effect of the cold pressor test on regional myocardial blood flow in patients with coronary artery disease. Am Heart J 106: 78–84, 1983.Google Scholar
  141. 141.
    Berkenboom GM, Abramowicz M, Vandermoten P, Degre, SG: Role of alpha adrenergic coronary tone in exercise-induced angina pectoris. Am J Cardiol 57: 195–198, 1986.PubMedGoogle Scholar
  142. 142.
    Sheridan DJ, Thomas P, Culling W, Collins P: Antianginal and hemodynamic effects of alphai adrenoceptor blockade. J Cardiovasc Pharmacol 8(Suppl 2): S144–S150, 1986.PubMedGoogle Scholar
  143. 143.
    Liang IYS, Jones CE: Alphai adrenergic blockade increases coronary blood, flow during coronary hypoperfusion. Am J Physiol 249: H1070–H1071, 1985.PubMedGoogle Scholar
  144. 144.
    Jones CE, Liang IYS, Maulsby MR: Cardiac and coronary effects of prazosin and phenoxybenzamine during coronary hypoperfusion. J Pharmacol Exp Ther-236: 204–211, 1986PubMedGoogle Scholar
  145. 145.
    Fallen EL, Elliott WC, Gorlin R: Mechanisms of angina in aortic stenosis. Circulation 36: 480–488, 1967.PubMedGoogle Scholar
  146. 146.
    Goodwin JF: Hypertrophic diseases of the myocardium. Prog Cardiovas Dis 16: 199–238, 1973.Google Scholar
  147. 147.
    Hurst JW, Logue RB, Schlant RO, Wenger NK: The Heart, Arteries and Veins. New York: McGraw-Hill, 1978, pp 1556–1590.Google Scholar
  148. 148.
    Harris CN, Aronow WS, Parker DP, Kaplan MA: Treadmill stress in left ventricular hypertrophy. Chest 63: 353–357, 1979.Google Scholar
  149. 149.
    Roberts JT, Wearn TJ: Quantitative changes in the capillary muscle relationships in human heart during growth and hypertrophy. Am Heart J 21: 617–633, 1941.Google Scholar
  150. 150.
    Linzbach AJ: Heart failure from the point of view of quantitative anatomy. Am J Cardiol 5: 370–382, I960Google Scholar
  151. 151.
    Arai S, Machida A, Nakamura T: Myocardial structure and vascularization of hypertrophied hearts. Tohoku J Exp Med 95: 35–54, 1968.PubMedGoogle Scholar
  152. 152.
    Rakusan K: Quantitative morphology of capillaries of the heart: Number of capillaries in animal and human hearts under normal and pathological conditions. Methods Archiev Exp Pathol 5: 272–286, 1971.Google Scholar
  153. 153.
    Zoll PM, Wessler S, Schlesinger MJ: Interarterial coronary anastomoses in the human heart, with particular reference to anemia and relative cardiac anoxia. Circulation 4: 797–8151951PubMedGoogle Scholar
  154. 154.
    Moller JH, Nakeb A, Edwards JE: Infarction of the papillary muscle and mitral insufficiency associated with congenital aortic stenosis. Circulation 34: 87–91, 1966.PubMedGoogle Scholar
  155. 155.
    Buchner F: Qualitative morphology of heart failure: Light and electron miscoscopic characteristics of acute and chronic heart failure. Methods Archiev Exp Pathol 5:60–120, 1971.Google Scholar
  156. 156.
    Marchetti GV, Merlo L, Noseda V, Visioli O: Myocardial blood flow in experimental cardiac hypertrophy in dogs. Cardiovasc Res 7: 519–527, 1973.PubMedGoogle Scholar
  157. 157.
    Holtz J, Von Restorff W, Bard P, Bassenge E: Transmural distribution of myocardial blood flow and of coronary vascular reserve in canine left ventricular hypertrophy. Basic Res Cardiol 72: 86–92, 1977.Google Scholar
  158. 158.
    O’Keefe DD, Hoffman JIE, Cheitlin R, O’Neill MJ, Allard JR, Shapkin E: Coronary blood flow in experimental canine left ventricular hypertrophy. Circ Res 43: 43–51, 1978.PubMedGoogle Scholar
  159. 159.
    Vrobel TR, Ring W, Anderson RW, Emery RW, Bache RJ: Effect of heart rate on myocardial blood flow in dogs with left ventricular hypertrophy. Am J Physiol 239: H621–H627, 1980.PubMedGoogle Scholar
  160. 160.
    Bache RJ, Vrobel TR: Effects of exercise on blood flow in the hypertrophied heart. Am J Cardiol 44: 1029–1033, 1979.PubMedGoogle Scholar
  161. 161.
    Mueller TM, Marcus ML, Kerber RE, Young JA, Barnes RW, Abboud FM: Effect of tenal hypertension and left ventricular hypertrophy on the coronary circulation in dogs. Circ Res 42: 543–549, 1978.PubMedGoogle Scholar
  162. 162.
    Malik AB, Abe T, O’Kane H, Geha AS: Cardiac function, coronary flow, and oxygen consumption in stable left ventricular hypertrophy. Am J Physiol 225: 186–191, 1973.PubMedGoogle Scholar
  163. 163.
    Wangler RD, Peters KG, Marcus ML, Tomanek RJ: Effects of duration and severity of arterial hypertension and cardiac hypertrophy on coronary vasodilator reserve. Circ Res 51: 10–18, 1982.PubMedGoogle Scholar
  164. 164.
    Marcus ML, Mueller TM, Gascho JA, Kerber RE: Effects of cardiac hypertrophy secondary to hypertension on the coronary circulation. Am J Cardiol 44: 1023–1028, 1979.PubMedGoogle Scholar
  165. 165.
    Murray PA, Vatner SF: Reduction of maximal coronary vasodilator capacity in conscious dogs with severe right ventricular hypertrophy. Circ Res 48: 27–33, 1981.Google Scholar
  166. 166.
    Archie JP, Fixier DE, Ullyot DJ, Buckberg GD, Hoffman JIE: Regional myocardial blood flow in lambs with concentric right ventricular hypertrophy. Circ Res 34: 143–154, 1974.PubMedGoogle Scholar
  167. 167.
    Murray PA, Baig H, Fishbein MC, Vatner SF: Effects of experimental right ventricular hypertrophy on myocardial blood flow in conscious dogs. J Clin Invest 64: 421–427, 1979.PubMedGoogle Scholar
  168. 168.
    Manohar M, thurmon JC, Tranquill WJJ, Devous MD, Theodorakis MC, Shawley RV, Feller DL, Benson JB: Regional myocardial blood flow and coronary vascular reserve in unanesthetized young calves with severe concentric right ventricular hypertrophy. Circ Res 48: 785–796, 1982.Google Scholar
  169. 169.
    Bache RJ, Vrobel TR, Ring WS, Emery RW, Anderson RW: Regional myocardial blood flow during exercise in dogs with chronic left ventricular hypertrophy. Circ Res 48: 76–87, 1981.PubMedGoogle Scholar
  170. 170.
    Rembert JC, Kleinman LH, Fedor JM, Wechsler AS, Greenfield JC Jr: Myocardial blood flow distribution in concentric left ventricular hypertrophy. J Clin Invest 62: 379–386, 1978.PubMedGoogle Scholar
  171. 171.
    Mittman U, Bruckner UB, Keller HE, Kohler U, Vetter H, Waag K-L: Myocardial flow reserve in experimental cardiac hypertrophy. Basic Res Cardiol 75: 199–206, 1980.Google Scholar
  172. 172.
    Breisch EA, Houser SR, Carey RA, Spann JF, Bove AA: Myocardial blood flow and capillary density in chronic pressure overload of the feline left ventricle. Cardiovasc Res 14: 469–475, 1980.PubMedGoogle Scholar
  173. 173.
    Lund DD, Tomanek RJ: Myocardial morphology in spontaneously hypertensive and aortic-constricted rats. Am J Anat 152: 141–151, 1978.PubMedGoogle Scholar
  174. 174.
    Henquell L, Odorff CL, Honig CR: Intercapillary distance and capillary reserve in hypertrophied rat hearts beating in situ. Circ Res 41: 400–408, 1977.PubMedGoogle Scholar
  175. 175.
    Mulvaney MJ, Hensen PK, Aalkjaer C: Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers. Circ Res 43: 854–864, 1978.Google Scholar
  176. 176.
    Warshaw DM, Mulvaney MJ, Halpern W: Mechanical and morphological properties of arterial resistance vessels in young and old spontaneously hypertensive rats. Circ Res 45: 250–259, 1979.PubMedGoogle Scholar
  177. 177.
    Noreson E, Hallback M, Hjalmarsson A: Structural “resettine” of the coronary vascular bed in spontaneously hypertensive rats. Acta Physiol Scand 101: 363–365, 1977.Google Scholar
  178. 178.
    Yamori Y, Mori C, Nishio T, Ooshima A, Hork R, Ohtaka M, Soeda T, Saito M, Abe K, Nata Y, Nakao Y, Kihara M: Cardiac hypertrophy in early hypertension. Am J Cardiol 44: 964–969, 1979.PubMedGoogle Scholar
  179. 179.
    Strauer BE: Hypertensive Heart Disease. New York: Springer-Verlag, 1980.Google Scholar
  180. 180.
    Strauer BE: Ventricular function and coronary hemodynamics in hypertensive heart disease. Am J Cardiol 44: 999–1006, 1979.PubMedGoogle Scholar
  181. 181.
    Tauchert M, Hilger HH: In: Schaper W (ed) The Patho-Physiology of Myocardial Perfusion, Amsterdam: Elsevier, North Holland, 1979, pp 141–167Google Scholar
  182. 182.
    Doty D, Wright C, Eastham C, Marcus ML: Coronary reserve in atrial septal defect. Circulation 62: 111–115, 1980.Google Scholar
  183. 183.
    Marcus ML, Doty DB, Hiratzka LF, Wright CB, Eastham CL: Impaired coronary reserve in children with cyanotic congenital heart disease. Circulation (Suppl) 64: IV–127, 1981.Google Scholar
  184. 184.
    Marcus ML, Doty DB, Hiratzka LF, Wright C, Eastham C: Decreased coronary reserve. A mechanism of angina patients with aortic stenosis and normal coronary arteries. N Engl JMed 307: 1362–1366, 1982.Google Scholar
  185. 185.
    Marcus ML, Wright C, Doty D, Eastham L, Laughlin D, Krumm P, Fastenow C, Brody M: Measurements of coronary velocity and reactive hyperemia in the coronary circulation of humans. Circ Res 49: 877–891, 1981.PubMedGoogle Scholar
  186. 186.
    Harrison DG, Barnes DH, Hiratzka LF, Eastham CL, Kerber RE, Marcus ML: The effect of cardiac hypertrophy on the coronary collateral circulation. Circulation 71: 1135–1145, 1985.PubMedGoogle Scholar
  187. 187.
    Koyanagi S, Eastham C, Marcus ML: Effects of chronic hypertension and left ventricular hypertrophy on the incidence of sudden cardiac death following coronary occlusion in conscious dogs. Circulation 65: 1192–1197, 1982.PubMedGoogle Scholar
  188. 188.
    Alyono D, Anderson RW, Parrish, DG, Dia XZ, Bache RJ: Alterations of myocardial blood flow associated with experimental canine left ventricular hypertrophy secondary to valvular aortic stenosis. Circ Res 58: 47–57, 1986.PubMedGoogle Scholar
  189. 189.
    Alyono D, Anderson RW, Parrish, DG, Dia XZ, Bache RJ: Alterations of myocardial blood flow associated with experimental canine left ventricular hypertrophy secondary to valvular aortic stenosis. Circ Res 58: 47–57,1986. PubMedGoogle Scholar
  190. 190.
    Tomanek RJ,Palmer PJ, Peiffer GL, Schreiber Kl, Eastham CL, Marcus ML:Morphomentry of canine coronary arteries,arterioles, and capillaries during hypertension and left ventricular hypertrophy. CirRes 58: 38–46, 1986.Google Scholar
  191. 191.
    Tomanek RJ, Wangler RD and Bauer CA: Prevention of coronary vasodilator reserve decrement in spontaneously hypertensive rats. Hypertension 7: 533–540, 1985.PubMedGoogle Scholar
  192. 192.
    Tomanek RJ, Searls JC, Lachenbruch PA: Quantitative changes in the capillary bed during developing, peak, and stabilized cardiac hypertrophy in the spontaneously hypertenisve rat. Circ Res 51: 295–304, 1982.PubMedGoogle Scholar
  193. 193.
    Tomanek RJ, Hovanec JM: The effects of long-term pressure-overload and aging on the myocardium. J Mol Cell Cardiol 13: 471–488, 1981.PubMedGoogle Scholar
  194. 194.
    Crisman RP, Tomanek RJ. Exercise-induced capillary growth in the spontaneously hypertensive rat. Microvasc Res 30: 185–194, 1985.PubMedGoogle Scholar
  195. 195.
    Bache RJ, Vrobel TR, Arentzen CE, Ring WS: Effect of maximal coronary vasodilation on transmural myocardial perfusion during tachycardia in dogs with left ventricular hypertrophy. Circ Res 49: 742–750, 1981.PubMedGoogle Scholar
  196. 196.
    Marcus ML, Mueller TM, Eastham CL: Effects of short- and long-term left ventricular hypertrophy on coronary circulation. Am J Physiol 241: H358–3612, 1981.PubMedGoogle Scholar
  197. 197.
    Bache RJ, Arentzen CE, Simon AB, Vrobel RT: Abnormalities in myocardial perfusion during tachycardia in dogs with left ventricular hypertrophy. Metabolic evidence for myocardial ischemia. Circulation 69: 409–417, 1984.Google Scholar
  198. 198.
    Wyse RKA, Jones M, Weiham KC, deLeval MR: Cardiac performance and myocardial blood flow in pigs with compensated right ventricular hypertrophy. Cardiovasc Res 18: 733–745, 1984.PubMedGoogle Scholar
  199. 199.
    Blumgart HL, Schlesinger MJ, Davis O: Studies on the relation of the clinical manifestations of angina pectoris, coronary thrombosis and myocardial infarction to the pathologic finding with particular reference to the significance of the collateral circulation. Am Heart J 19: 1–91, 1940.Google Scholar
  200. 200.
    Doty DB, Eatham CL, HiratzkaLF, Wright CB, Marcus ML: Determination of coronary reserve in patients with supravalvular aortic stenosis. Circulation (Suppl I) 66: 1186–1192, 1982.Google Scholar
  201. 201.
    Peters KG, Wangler RD, Tomanek RJ, Marcus ML: Effects of long-term cardiac hypertrophy on coronary vasodilator reserve in SHR rats. Am J Cardiol 54: 1342–1348, 1984.PubMedGoogle Scholar
  202. 202.
    Schaper W: The Collateral Circulation of the Heart. Amsterdam: North Holland, 1971.Google Scholar
  203. 203.
    Gregg DE: The natural history of collateral development. Circ Res 35: 335–344, 1974.PubMedGoogle Scholar
  204. 204.
    Schwarz F, Wagner HO, Sesto M, Hofmann M, Schaper W, Kubler W: Native collaterals in the development of collateral circulation after chronic coronary stenosis in mongrel dogs. Circulation 66: 303–308, 1982.PubMedGoogle Scholar
  205. 205.
    Schwarz F, Flameng W, Ensslen R, Sesto M, Thormann J: Effect of coronary collaterals on left ventricular functions at rest and during stress. Am Heart J 95: 570–577, 1978.PubMedGoogle Scholar
  206. 206.
    Kelly DT, Pitt B: Regional changes in intramyo-cardial pressure following myocardia ischemia. In: Bloor CM, Olsson RA (eds) Current topics in coronary Research, Vol 39. New York: Plenum, 1973, pp 115–130.Google Scholar
  207. 207.
    Bache RJ, Cobb FR, Greenfield JC: Myocardial blood flow distribution during ischemia-induced coronary vasodilation in the unanesthetized dog. J Clin Invest 54: 1462–1472, 1974.PubMedGoogle Scholar
  208. 208.
    Tennant R, Wiggers CJ: The effect of coronary occlusion on myocardial contraction. Am J Physiol 112: 351–361, 1935.Google Scholar
  209. 209.
    Katz AM: Effects of ischemia on the contractile process of heart muscle. Am J Cardiol 32: 456–460, 1973.PubMedGoogle Scholar
  210. 210.
    Hillis LD, Braunwald E: Myocardial ischemia. N Eng J Med 296: 971–978, 1977.Google Scholar
  211. 211.
    Theroux P, Franklin D, Ross J, Kemper WS: Regional myocardial function during acute coronary artery occlusion and its modification by pharmacologic agents in the dog. Circ Res 35: 896–908, 1974.PubMedGoogle Scholar
  212. 212.
    Aversano T, Becker LC: Persistence of coronary vasodilator reserve despite functionally significant flow reduction. Am J Physiol 248: H403–H411, 1985.PubMedGoogle Scholar
  213. 213.
    Folts JD, Gallagher K, Rowe GG: Blood flow reductions in stenosed canine coronary arteties: Vasospasm or platelet aggregation? Circulation 65: 248–255, 1982.PubMedGoogle Scholar
  214. 214.
    Powets ER, DiBona DR, Powell J Jr: Myocardial cell volume and coronary resistance during diminished coronary perfusion. Am J Physiol 247: H467–H477, 1984.Google Scholar
  215. 215.
    Engler RL, Dahlgren MD, Morris DD, Peterson MA, Schmid-Schonbein GW: Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am J Physiol 215: H314–H322, 1986.Google Scholar
  216. 216.
    Pantely GA, Bristow JD, Swenson LJ, Ladley HD, Johnson WB, Anselone CG: Incomplete coronary vasodilation during myocardial ischemia in swine. Am J Physiol 249: H638–H647, 1985.PubMedGoogle Scholar
  217. 217.
    Gallagher KP, Folts JD, Shebuski RJ, Rankin JHG, Rowe GG: Subepicatdial vasodilator reserve in the presence of critical coronary stenosis in dogs. Am J Cardiol 46: 67–73, 1980.PubMedGoogle Scholar
  218. 218.
    Canty JM Jr, Kloeke FJ: Reduced regional myocardial perfusion in the ptesence of pharmacologic vasodilator reserve. Circulation 71: 370–377, 1985.PubMedGoogle Scholar
  219. 219.
    Grover GJ, Weiss HR: Effect of pacing on oxygen supply-to-consumption ratio in ischemic myocardium. Am J Phsyiol 249: H249–H254, 1985.Google Scholar
  220. 220.
    Engler RL, Dahlgren MD, Peterson MA, Dobbs A, Schmid-Schonbein GW: Accumulation of polymot-phonuclear leukocytes during 3-h experimental myocardial ischemia. Am J Physiol 251: H93–H100, 1986.PubMedGoogle Scholar
  221. 221.
    Grattan MT, Hanley FL, Stevens MB, Hoffman JIE: Transmural coronary flow reserve patterns in dogs. Am J Physiol 250: H276–H283, 1986.PubMedGoogle Scholar
  222. 222.
    Heusch G, Deussen A: The effects of cardiac sympathetic nerve stimulation on perfusion of stenotic coronary arteries in the dog. Circ Res 53: 8–15, 1983.PubMedGoogle Scholar
  223. 223.
    Cuttino JT Jt, Bartrum RJ Jr, Hollenberg NK, Abrams HL: Collateral vessel formation: Isolation of a transferable factor promoting a vascular response. Basic Res Cardiol 70: 568–573, 1975.Google Scholar
  224. 224.
    Golenhofen K, Mandrek K, Schaper W, et al: Mechanical activity of isolated canine coronary arteties after coronary occlusion. Basic Res Cardiol 76: 4802013484, 1981.Google Scholar
  225. 225.
    Frame LH, Powell WJ: Progressive perfusion impairment during prolonged low flow myocardial ischemia in dogs. Circ Res 39: 269–276, 1976.PubMedGoogle Scholar
  226. 226.
    Guyton RA, McClenathan JH, Michaelis LL: Evolution of regional ischemia distal to a proximal coronary stenosis: Self-propagation of ischemia. Am J Cardiol 40: 381–392, 1977.PubMedGoogle Scholar
  227. 227.
    Sparks HV, Gorman MG: Ischemic vasodilation or ischemic vasoconstriction? In: Vanhoutte PM, Leusen I (eds) Vasodilation. New York: Raven Press, 1981, pp 193–204.Google Scholar
  228. 228.
    Gorman MG, Sparks HV: Progressive coronary vasoconstriction during relative ischemic in canine myocardium. Circ Res 51: 411–420, 1982.PubMedGoogle Scholar
  229. 229.
    Harris TR, Overholser KA, Stiles RG: Concutrent increases in resistance and ttansport aftet coronary obstruction in dogs. Am J Physiol 240: H262–H273, 1981.PubMedGoogle Scholar
  230. 230.
    Willetson JT, Powell WJ, Guiney TE, Stark JJ, Sanders CA, Leaf A: Improvement in myocardial function and coronary blood flow in ischemic myocardium after mannitol. J Clin Invest 51: 2989–2998, 1972.Google Scholar
  231. 231.
    Wangler RD, De Witt DF, Spatks HV: Effect of ß-blockade on nucleoside release from the hypopet-fused isolated heatt. Am J Physiol 247: H330–H336.Google Scholar
  232. 232.
    Kloeke FJ, Canty JM Jr, Arani DT, Krawczuk JA: Adjustments in regional coronary perfusion accompanying reductions in regional coronary arterial pressure. Cardiology, in press.Google Scholar
  233. 233.
    Willerson JT, Watson JT, Hutton I, Templeton GH, Fixier DE: Reduced myocardial reflow and increased coronary vascular resistance following prolonged myocardial ischemia in the dog. Circ Res 36: 771–781, 1975.PubMedGoogle Scholar
  234. 234.
    Parker PE, Bashour FA, Downey HF, Kechejian SJ, Williams AF: Coronary hemodynamics during reperfusion following acute coronary ligation in dogs. Am Heart J 90: 593–599, 1975.PubMedGoogle Scholar
  235. 235.
    Kloner RA, Ganote CE, Jennings RB: The“no-reflow” phenomenon after temporary coronary occlusion in the dog. J Clin Invest 54: 1496–1507, 1974.PubMedGoogle Scholar
  236. 236.
    Patker PE, Bashour FA, Downey HF, Bouvros IS: Coronary reperfusion: Effects of hyperosmotic manitol. Am Heart J 97: 745–752, 1979.Google Scholar
  237. 237.
    Sunnergren KP, Rovetto MJ: Hyaluronidase reversal of increased coronary vascular resistance in ischemic rat hearts. Am J Physiol 245: H183–H188, 1983.PubMedGoogle Scholar
  238. 238.
    Marcus ML, Kerber RE, Ehrhardt J, Abboud FM: Effects of time on volume and distribution of coronary collateral flow. Am J Physiol 230: 279–285, 1976.PubMedGoogle Scholar
  239. 239.
    Jugdutt BI, Becker LC, Hutchins GM: Eatly changes in collateral blood fow during myocardial infarction in conscious dogs. Am J Physiol 237: H371–H380, 1979.PubMedGoogle Scholar
  240. 240.
    Schaper W, Pasyk S: Influence of collatetal flow on the ischemic tolerance of the heart 240.following acute and subacute coronary occlusion. Circulation (Suppl 1) 53: 157–162, 1976. Google Scholar
  241. 241.
    Khouri EM, Gregg DE, McGranahan GM: Regression and reappearance of coronary collaterals. Am J Physiol 220: 655–661, 1971.PubMedGoogle Scholar
  242. 242.
    Eckstein RW: Effect of exercise and coronary artery narrowing on coronary collateral circulation. Cite Res 5: 230–235, 1957.Google Scholar
  243. 243.
    Sanders M, White FC, Peterson TM, Bloor CM: Effects of endurance exercise on coronary collateral blood flow in minature swine. Am J Physiol 234: H614–H619, 1978.PubMedGoogle Scholar
  244. 244.
    Scheel KW, Ingram LA, Wilson JL: Effects of exercise on the coronary and collateral vasculature of beagles with and without coronary occlusion. Circ Res 48: 523–530, 1981.PubMedGoogle Scholar
  245. 245.
    Scheel KW, Brody DA, Ingram LA, Keller F: Effects of chronic anemia on the coronary collateral vasculature in dogs. Circ Res 38: 553–559, 1976.PubMedGoogle Scholar
  246. 246.
    Scheel KW, Rodriguez RJ, Ingram LA: Directional coronary collateral growth with chronic circumflex occlusion in the dog. Circ Res 40: 384–390, 1977.PubMedGoogle Scholar
  247. 247.
    Eckstein RW: Development of interarterial coronary anastomoses by chronic anemia: Disappearance following correction of anemia. Circ Res 3: 306–310, 1955.PubMedGoogle Scholar
  248. 248.
    Blum RL, Alpern H, Jaffe H, Lang TW, Corday E: Determination of interarterial coronary anastomosis by radioactive spherules: Effect of coronary occlusion and hypoxemia. Am Heart J 79: 244–249, 1970.PubMedGoogle Scholar
  249. 249.
    Jackson WF, Duling BR: The oxygen sensitivity of hamster cheek pouch arterioles. Circ Res 53: 515–525, 1983.PubMedGoogle Scholar
  250. 250.
    Nathan HJ, Feigl EO: Adrenergic vasoconstriction lessens transmural steal during coronary hypoperfusion. Am J Physiol 250 (Heart Circ Physiol 19): H645–H653, 1986.PubMedGoogle Scholar
  251. 251.
    Feigl EO: Parasympathetic control of coronary blood flow in dogs. Circ Res 25: 509–519, 1975.Google Scholar

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© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Harvey V. SparksJr
  • Roger D. Wangler
  • Mark W. Gorman

There are no affiliations available

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