Abstract
Vascular smooth-muscle contractility is regulated by a variety of membrane and intracellular effectors. In many cases, these effectors operate through alterations in intracellular cyclic nucleotide levels. Since the contractile state of smooth muscle is dependent on the concentration of intracellular activator calcium ([Ca2+]i), the relationship between this ion and cyclic nucleotides is central to the regulation of vascular tone. The complexity of this issue is illustrated by the observations of Ca2+-dependent changes in cyclic nucleotide levels and cyclic-nucleotide-mediated alterations of vascular tone independent of changes in [Ca2+]i.
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Bennett, B.M., Molina, C.R., Waldman, S.A., Murad, F. (1989). Cyclic Nucleotides and Protein Phosphorylation in Vascular Smooth-Muscle Relaxation. In: Sperelakis, N. (eds) Physiology and Pathophysiology of the Heart. Developments in Cardiovascular Medicine, vol 90. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0873-7_40
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