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Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle

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Physiology and Pathophysiology of the Heart

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 90))

Abstract

The contractile response of smooth-muscle cells is triggered by an increase of the free cytoplasmic concentration of calcium ions. In skinned smooth-muscle fibers, i.e., tissues from which the cell membrane has been chemically removed by detergent treatment, the threshold Ca concentration for initiating contraction amounts to approximately 10-7 M, and full activation of the contractile proteins occurs at about 10-5 M calcium {1–3}.

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  1. G. Droogmans
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  2. R. Casteels
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Editors and Affiliations

  1. Department of Physiology and Biophysics and College of Medicine, University of Cincinnati, 231 Bethesda Avenue, 45267-0579, Cincinnati, OH, USA

    Nicholas Sperelakis

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Droogmans, G., Casteels, R. (1989). Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle. In: Sperelakis, N. (eds) Physiology and Pathophysiology of the Heart. Developments in Cardiovascular Medicine, vol 90. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0873-7_39

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  • DOI: https://doi.org/10.1007/978-1-4613-0873-7_39

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