Aging of the Adult Heart

  • Edward G. Lakatta
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 90)


Both quantitative and qualitative assessments of normal cardiovascular function differ with age of the organism studied {1-4}. Thus, functional studies of the normal heart at a single age are incomplete and represent only a point on a continuum. A full understanding of heart function in stressful or pathologic states must consider that age-related changes modify the substrate upon which the stress or disease process is super-imposed and that the expression of a given pathologic state is not solely due to the disease per se but represents an age-disease interaction. Striking examples of this interaction can be observed in cardiac overload states {5} or in the effect of adaptation of the myocardium to chronic physical conditioning {6}.


ATPase Activity Sarcoplasmic Reticulum Cardiac Muscle Adult Heart Inotropic Response 
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© Kluwer Academic Publishers 1989

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  • Edward G. Lakatta

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