Abstract
The autonomic nervous system is the major system extrinsic to the heart that regulates myocardial contractility. This system can be subdivided on the basis of anatomy, functional effects, and neurotransmitters released from postganglionic nerves into two major divisions, sympathetic and parasympathetic nervous systems (fig. 20-1). In general, an increase in sympathetic nerve activity stimulates the heart (i.e., increases heart rate, conduction velocity through the specialized conducting tissues, and myocardial contractility), whereas augmentation of parasympathetic activity is inhibitory. The heart is innervated by sympathetic nerves and the vagus, which is the parasympathetic innervation. The neurotransmitter released from preganglionic nerves in both the sympathetic and parasympathetic nervous systems is acetylcholine. Norepinephrine is the neurotransmitter that is released from postganglionic sympathetic nerves that innervate the heart. The transmitter released from postganglionic parasympathetic (vagal) nerve endings is acetylcholine (fig. 20-1). Both norepinephrine and acetylcholine produce their effects locally in the immediate area into which they are released, that is, they function as neurotransmitters. Epinephrine is a catecholamine that is released from the adrenal medulla and travels via the circulation to the heart and thus functions as a hormone.
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References
Levy MN, Martin PJ: Neural control of the heart. In: Handbook of Physiology — The Cardiovascular System. I. Bethesda: American Physiological Society, 1979, pp 581–620.
Watanabe AM, Jones LR, Manalan AS, Besch HR Jr: Cardiac autonomic receptors: Recent concepts from radiolabelled ligand studies. Circ Res 50: 161–174, 1982.
Stiles GL, Caron MG, Lefkowitz RJ: ß-adrenergic receptors: Biochemical mechanisms of physiologic regulation. Physiol Reviews 64: 661–743, 1984.
Levitski A: ß-adrenergic receptors and their mode of coupling to adenylate cyclase. Physiol Rev 66: 819–854, 1986.
Birnbaumer L, Codina J, Mattera R, Cenone RA, Hildebrandt JD, Sunyer T, Rojas F, Caron MG, Lefkowitz RJ, Iyengar R: Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. Ree Prog Hormone Res 41: 41–99, 1985.
Hancock AA, De Lean AL, Lefkowitz RJ: Quantitative resolution of ß-adrenergic receptor subtypes by selective ligand binding: Application of a computerized model fitting technique. Mol Pharmacol 16: 1–9, 1980.
Carlsson E, Dahlof C, Hedberg A, Tangstrand B: Differentiation of cardiac chronotropic and inotropic of ß-adrenoeeptor agonists. Naunyn-Schmiedeberg’s Arch Pharmacol 300: 101–105, 1977.
Liang BT, Frame LH, Molinoff, PB: ß2-adrenergic receptors contribute to catecholamine-stimulated shortening of action potential duration in dog atrial muscle. Proc Natl Acad Sei USA 82: 4521–4525, 1985.
Jones LR, Maddock SW, Besch HR Jr: Unmasking effect of alamethicin on the (Na+, K+)-ATPase, ß-adrenergic receptor-coupled adenylate cyclase, and cAMP-dependent protein kinase activities of cardiac sarcolemmal vesicles. J Biol Chem 255: 9971–9980, 1980.
Manalan AS, Jones LR: Characterization of the intrinsic cAMP-dependent protein kinase activity and endogenous substrates in highly purified cardiac sarcolemmal vesicles. J Biol Chem 257: 10052–10062, 1982.
Fräser J, Nadeau, J, Robertson D, Wood AJJ: Regulation of human leukocyte beta receptors by endigenous catecholamines: Relationship of leukocyte beta receptor density to the cardiac sensitivity to isoproterenol. J Clin Invest 67: 1777–1784, 1981.
Bristow MR, Ginsburg R, Minobe W, Cunbicciotti RS, Sageman WS, Lurie K, Billingham ME, Harrison DC, and Stinson EG: Decreased catecholamine sensitivity and ß-adrenergic receptor density in failing human hearts. N Engl J Med 307: 205–211, 1982.
Thomas JA, Marks BH: Plasma norepinephrine in congestive heart failure. Am J Cardiol 41: 233–43, 1978.
McMonnaughey MM, Jones LR, Watanabe AM, Besch HR Jr, Williams LT, Lefkowitz RJ:Thyroxineand propylthiouracil effects on α- and ß-adrenergic receptor number, ATPase activities, and sialic acid content of rat cardiac membrane vesicles. J Cardiovasc Pharmacol 1; 609–623, 1979.
Williams LT, lefkowitz RJ, Watanabe AM, Hathaway DR, Besch HR Jr: Thyroid hormone regulation of ß-adrenergic receptor number. J Biol Chem 252: 2767–2769, 1977.
Ginsberg AM, Clutter WE, Shah SD, Cryer PE: Triiodothyronine-induced thyrotoxicosis increases mononuclear leukocyte ß-adrenergic receptot density in man. J Clin Invest 67: 1785–1791, 1981.
Sibley DR, Lefkowitz RJ: Molecular mechanisms of receptor desensitization using the ß-adrenergic receptot-coupled adenylate cyclase system as a model. Nature 317: 124–429, 1985.
Strasser RH, Sibley DR, Lefkowitz RJ: A novel catecholamine activated adenosine cyclic 3’,5’-phosphate independent pathway fot ß-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: Mechanism of homologous desensitization of adenylate cyclase. Biochemistry 25: 1371–1377, 1986.
Besch HR Jr, Jones LR, Fleming JW, Watanabe AM: Parallel unmasking of latent Na+, K+-ATPase and adenylate cyclase activities in catdiac satcolemmal vesicles: A new use of the channel-fotming iono-phore alamethicin. J Biol Chem 252: 7905–7908, 1977.
Ross EM, Gilman AG: Biochemical properties of hormone-sensitive adenylate cyclase. Ann Rev Biochem 49: 533–564, 1980.
Drummond Gl: Resolution and properties of the catalytic subunit of cardiac adenylate cyclase. J Mol Cell Cardiol 17: 183–194, 1985.
Seamon KB, Daly JW: Guanosine 5’-(ß, y-imido) triphosphate inhibition of forskolin-activated adenylate cyclase is mediated by the putative inhibitory guanine nucleotide regulatory protein. J Biol Chem 257: 11591–11596, 1982.
Smith SK, Limbird LL:Evidence that human platelet α-adrenergic receptors coupled to inhibition of adenylate cyclase are not associated with the subunit of adenylate cyclase ADP-ribosylated by choleta toxin. J Biol Chem 257: 10471–10478, 1982.
Hildebrandt JD, Hanoune J, Birnbaumer L: Guanine nucleotide inhibition of cyc S49 mouse lymphoma cell membrane adenylate cyclase. J Biol Chem 257: 14723–14725, 1982.
Watanabe AM, McConnaughey MM, Strawridge RA, Fleming JW, Jones LR, Besch HR Jr: Muscarinic cholinergic receptor modulation of ß-adrenergic receptor affinity for catecholamine. J Biol Chem 253: 4833–4836, 1978.
Gilman AG :G proteins and dual control of adenylate cyclase. Cell 36: 577–579, 1984.
Ueda K, Hayaishi O: ADP-ribosylätion. Ann Rev Biochem 54: 73–100, 1985.
Cerione RA, Staniszewski C, Gietschick P, Codina J, Somers RL, Birnbaumer L, Spiegel AM, Caron MG, Lefkowitz RJ: Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. J Biol Chem 261: 9514–9520, 1986.
Fleming JW, Strabridge RA, Watanabe AM: Muscarinic receptor regulation of cardiac adenylate cyclase activity. J Mol Cell Cardiol 19: 47–61, 1987.
Krebs EG, Beavo JA: Phosphorylation-dephosphorylation of enzymes. Ann Rev Biochem 48: 923–959, 1979.
Corbin JD, Sudgen PH, Lincoln TM, Keely SL: Compartmentalization of adenosine 3’5’-monophosphate and adenosine 3’:5’-monophosphate-dependent protein kinase in heart tissue. J Biol Chem 252: 3854–3861, 1977.
Hayes JS, Brunton LL, Mayer SE: Selective activation of particulate cAMP-dependent protein kinase by isoproterenol and prostaglandin Ei. J Biol Chem 255: 5113–5119, 1980.
Buxton ILO, Brunton LL: compartments of cyclic AMP and protein kinase in mammalian cardiomyo-cytes. J Biol Chem 258: 10233–10239, 1983.
Stull JT, Mayer SE: Biochemical mechanisms of adrenergic and cholinergic regulation of myocardial contractility. In: Handbook of Physiology. The Cardiovascular System. Bethesda: American Physiological Society, 1979, pp 741–774.
England PJ: Studies on the phosphorylation of the inhibitory subunit of troponin during modification of contraction in perfused rat heart. Biochem J 160: 295–304, 1976.
Brunton LL, Hayes JS, Mayer SE: Hormonally specific phosphorylation of cardiac troponin I and activation of glycogen Phosphorylase. Nature 280: 78–80, 1979.
Robertson SP, Johnson JD, Holroyde MJ, Kranias EG, Potter JD, Solaro RJ: The effect of troponin I phosphorylation in the Ca2+-binding properties of the Ca2+-regulatory site of bovine cardiac troponin. J Biol Chem 257: 260–263, 1980.
Jeacocke SA, England PJ: Phosphorylation of a myofibrillar protein of Mr 150,000 in perfused rat heart, and the tentative identification of this as C-protein. FEBS Lett 122: 129–132, 1980.
Hartzel HC, Titus L: Effects of cholinergic and adrenergic agonists on phosphorylation of a 165,000-dalton myofibrillar protein in intact cardiac muscle. J Biol Chem 257: 2111–2121, 1982.
Hartzell HC: Phosphorylation of C-protein in intact amphibian catdiac muscle: Correlation between 32P incorporation and twitch relaxation. J Gen Physiol 83: 563–588, 1984.
Hartzell HC, Glass DB: Phosphorylation of purified cardiac muscle C-protein by purified cAMP-dependent protein kinase and endogenous Ca2+-calmodulin-dependent protein kinases. J Biol Chem 259: 15587–15596, 1984.
Winegrad S, Weisberg A, Lin LE, McClellan G: Adrenergic regulation of myosin adenosine triphosphatase activity. Circ Res 58: 83–95, 1986.
Kirchberger MA, Tada M: Effects of adenosine 3’:5’-monophosphate-dependent protein kinase on sarcoplasmic reticulum isolated from cardiac and slow and fast contracting skeletal muscles. J Biol Chem 251: 725–729, 1976.
Tada M, Katz AM: Phosphorylation of the sarcoplasmic reticulum and sarcolemma. Ann Rev Physiol 44: 401–423, 1982.
Jones LR, Simmerman HKB, Wilson WW, Gurd FRN, Wegener AD: Purification and characterization of phospholamban from canine cardiac sarcoplasmic reticulum. J Biol Chem 260: 7721–7730, 1985.
Fujii J, Ueno A, Katsuhiko K, Tanaka S, Kadoma M, Tada M: Complete complementary DNA-derived amino acid sequence of canine cardiac phospholamban. J Clin Invest 79: 301–304, 1987.
Suzuke T, Wang JH: Stimulation of bovine sarcoplasmic reticulum Ca2+ pump and blocking of phospholamban phosphorylation and dephosphorylation by a phospholamban monoclonal antibody. J Biol Chem 261: 7018–7023, 1986.
Le Peuch CJ, Guilleaux JC, De Maille JC: Phospholamban phosphorylation in the perfused rat heart is not solely dependent in beta adrenergic stimulation. FEBS Lett 114: 165–168, 1980.
Kranias EG, Solaro RJ: Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart. Nature 298: 182–184, 1982.
Lindemann JP, Jones LR, Hathaway DR, Henry BG, Watanabe AM: ß-adrenergic stimulation of phospholamban phosphorylation and Ca2+-ATPase activity in guinea pig ventricles. J Biol Chem 258: 464–471, 1984.
Mirro MJ, Bailey JC, Watanabe AM: Role of cyclic AMP in regulation of the slow inward current. In: Role of the Slow Inward Current in Cardiac Electro-physiology. The Hague: Martinus Nijhoff, 1980, pp 111–126.
Watanabe AM, Besch HR Jr: Cyclic adenosine monophosphate modulation of slow calcium influx channels in guinea pig hearts. Circ Res 35: 316–324, 1974.
Sperelakis N: Phosphorylation hypothesis of the myocardial slow channels and control of Ca2+ influx. In: Cardiac Electrophysiology and Arrhythmias. New York: Grune and Stratton, 1985, pp 123–135.
Reuter H: Calcium channel modulation by neurotransmitters, enzymes and drugs. Nature 301: 569–574, 1983.
Li T, Sperelakis N: Stimulation of slow action potentials in guinea pig papillary muscle cells by intracellular injection of cAMP, Gpp (NH)p, and cholera toxin. Circ Res 52: 111–117, 1983.
Osterreider W, Brum G, Hescheler J, Trautwein W, Hofmann F, Flockerzi V: Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current. Nature 298: 576–578, 1982.
Brum G, Flockerzi V, Hofmann F, Osterrieder W, Trautwein W: Injection of catalytic subunit of cAMP-dependent protein kinase into isolated cardiac myocytes. Pflügers Arch 398: 147–154, 1983.
Bean BP, Nowycky MC, Tsien RW: ß-adrenergic modulation of calcium channels in frog ventricular heart cells. Nature 307: 371–375, 1984.
Kameyama M, Hofmann F, Trautwein W: On the mechanism of ß-adrenergic regulation of the Ca channel in the guinea-pig heart. Pflügfers Arch 405: 285–293, 1985.
Kameyama M, Hescheler J, Hofmann F, Trautwein W: Modulation of Ca current during the phosphorylation cycle in the guinea pig heart. Pflügers Arch 407: 123–128, 1986.
Kameyama M, Hescheler J, Mieskes G, Trautwein W: The protein-specific phosphatase antagonizes the ß-adrenergic increase of the cardiac Ca current. Pflügers Arch 407: 461–463, 1986.
Jones LR, Presti CF, Lindemann JP: Protein phosphorylation and the cardiac sarcolemma. In: Protein Phosphorylation in Heart Muscle. Boca Raton, FL: CRC Press, 1986, pp 85–103.
Campbell KP, Lipshutz GM, Denney GH: Direct photoaffinity labeling of the high affinity nitrendi-pine-binding site in subcellular membrane fractions isolated ftom canine myocardium. J Biol Chem 259: 5384–5387, 1984.
Williams LT, Jones LR: Specific binding of the calcium antagonist {3H}nitrendipine to subcellular fractions isolated from canine myocardium. J Biol Chem 258: 5344–5347, 1983.
Walsh DA, Clippinger MS, Sivaramakrishnan S, McCullough TE: Cyclic adenosine monophosphate dependent and independent phosphorylation of sarcolemmal proteins in perfused rat heart. Biochemistry 18: 871–877, 1979.
Huggins JP, England PJ: Sarcolemmal phospholamban is phosphorylated in isolated rat hearts perfused with isoprenaline. FEBS Lett 163: 297–302, 1983.
Presti CF, Jones LR, Lindemann JP: lsoproterenol-induced phosphorylation of a 15-kilodalton sarcolemmal protein in intact myocardium. J Biol Chem 260: 3860–3867, 1985.
Lindemann JP: α-adrenergic stimulation of sarcolemmal protein phosphorylation and slow responses in intact myocardium. J Biol Chem 261: 4860–4867, 1986.
Tada M, Inui M, Yamada M, Kadoma M, Kuzuya T, Abe H, Kakiuchi S: Effects of phospholamban phosphorylation catalyzed by adenosine 3’, 5’-monophosphate- and calmodulin-dependent protein kinases on calcium transport ATPase of cardiac sarcoplasmic reticulum. J Mol Cell Cardiol 15: 335–346, 1982.
Kirchberger MA, Antonetz T: Calmodulin-mediated regulation of calcium transport and (Ca2+ + Mg2+)-activated ATPase activity in isolated cardiac sarcoplasmic reticulum. J Biol Chem 257: 5685–5691, 1982.
Simmerman HKB, Collins JH, Theibert JL, Wegener AD, Jones LR: Sequence analysis of phospholamban: Indentification of phosphorylation sites and two major structural domains. J Biol Chem 261: 13333–13341, 1986.
Lindemann JP, Watanabe AM: Phosphorylation of phospholamban in intact myocardium: Role of Ca2+-calmodulin-dependent mechanisms. J Biol Chem 260: 4516–4525, 1985.
Scholz H: Effects of ß- and a-adrenoreceptor activators and adrenergic transmitter releaseing agents on the mechanical activity of the heart. In: Handbook of Experimental Pharmacology, Vol 54/1. Berlin: Springer-Verlag, 1980, pp 651–733.
Benfey BG: Function of myocardial a-adrenoceptors. Life Sei 31: 101–112, 1982.
Miura Y, Inui J: Multiple effects of α-adrenoceptor stimulation on the action potential of the rabbit atrium. Naunyn-Schmideberg’s Arch Pharmacol 325: 47–53, 1984.
Bruckner R, Scholz H: Effects of a-adrenoreceptor stimulation with phenylephrine in the presence of propranolol on force of contraction, slow inward current and cyclic AMP content in the bovine heart. Br J Pharmac 82: 223–232, 1984.
Williams RS, Lefkowitz RJ: (X-adrenergic receptors in rat myocardium: Identification by binding of [3H]dihydroergocryptine. Circ Res 43: 721–727, 1978.
Karliner JS, Barnes P, Hamilton CA, Dollery CT: Alphai-adrenergic receptors in guinea pig myocardium: Identification by binding of a new radioligand, (3H)-prazosin. Biochem Biophys Res Commun 90: 142–149, 1979.
Karliner JS, Barnes P, Brown M, Dollery C: Chronic heart failure in the guinea pig increases cardiac arand ß-adrenoeeptors. Eur J Pharmacol 67: 115–118, 1980.
Berridge MJ: Inositol trisphosphate and diacylgly-cerol as second messengers. Biochem J 220: 345–360, 1984.
Williamson JR, Cooper RH, Joseph SK, Thomas AP: Inositol trisphosphate and diacylglycerol as intracellular second messengers in liver. Am J Physiol 248: C203–C216, 1985.
Brown JH, Jones LG: Phosphoinositide metabolism in the heart. In: Phosphoinositides and Receptor Mechanisms. New York: Alan R Liss, 1986, pp 245–270.
Nishizuka Y: The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308: 693–698, 1984.
Volpe P, Salviati G, Di Virgilio F, Pozzan T: Inositol-1, 4, 5 trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle. Nature 316: 347–349, 1985.
Nosek TM, Williams MF, Zeigler ST, Godt RE:Inositol trisphosphate enhances calcium release in skinned cardiac and skeletal muscle. Am J Physiol 250: C807–C811, 1986.
Movsesian MA, Thomas AP, Williamson JR: Inositol trisphosphate does not release Ca2+ from permeabilized cardiac myocytes and sarcoplasmic reticulum. FEBS Lett 185: 328–332, 1984.
Wise BC, Raynor RL, Kuo JF: Phospholipid-sensitive Ca2+-dependent protein kinase from heart. I. Purification and general properties. J Biol Chem 257: 8481–8488, 1982.
Iwasa Y, Hosey MM: Phosphorylation of cardiac sarcolemma proteins by the calcium-activated phos-pholipid-dependent protein kinase. J Biol Chem 259: 534–540, 1984.
Presti CF, Scott BT, Jones LR: Identification of an endogenous protein kinase C activity and its intrinsic 15-kilodalton substrate in purified canine cardiac sarcolemmal vesicles. J Biol Chem 260: 13879–13889, 1985.
Loffelholz K, Pappano AJ: The parasympathetic neuroeffector junction of the heart. Pharmacol Rev 37: 1–24, 1985.
Levy MN: Sympathetic-parasympathetic interactions in the heart. Circ Res 29: 437–445, 1971.
Birdsall NJM, Hulme EC: Biochemical studies on muscarinic acetylcholine receptors. J Neurochem 27: 7–16, 1976.
Ehlert FJ, Roeske WR, Yamamura HI: The nature of muscarinic receptor binding. In: Handbook of Psychopharmacology. New York: Plenum, 1983, pp 241–283.
Mattera R, Pitts BJR, Entman ML, Birhbaumer L: Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. J Biol Chem 260: 7410–7421, 1985.
Brown JH, Goldstein D, Masters SB: The putative Mi muscarinic receptor does not regulate phosphoinositide hydrolysis. Mol Pharmacol 27: 525–531, 1985.
Manalan AS, Werth DK, Jones LR, Watanabe AM: Enrichment, solubilization, and partial characterization of digitonin-solubilized muscarinic receptors derived from canine ventricular myocardium. Circ Res 52: 664–676, 1983.
Florio VA, Sternweiss PC: Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins. J Biol Chem 260: 3477–3483, 1985.
Kurose H, Katada T, Haga T, Haga K, Ichiyama A, Ui M: Functional interactioin of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J Biol Chem 261: 6423–6428, 1986.
Haga K, Haga T, Ichiyama A, Katada T, Kurose H, Ui M: Functional reconstitution of purified muscarinic receptors and inhibitory guanine nucleotide regulatory protein. Nature 316: 731–733, 1985.
Galper JB, Smith TW: Properties of muscarinic acetylcholine receptors in heart cell cultures. Proc Natl Acad Sei USA 75: 5831–5835, 1978.
Roskoski R Jr, Reinhardt RR, Enseleit W, Johnson WD, Cook PD: Cardiac cholinergic muscarinic receptors: Changes in multiple affinity forms with down regulation. J Pharmacol Exp Ther 232: 754–759, 1985.
Halvorsen SW, Nathanson NM: In vivo regulation of muscarinic acetylcholine receptor number and function in embryonic chick heart. J Biol Chem 256: 7941–7948, 1981.
Kwatra MM, Hosey MM: Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist. J Biol Chem 261: 12429–12432, 1986.
Sharma VK, Banerjee SP: Muscarinic cholinergic receptors in rat heart: Effect of thyroidectomy. J Biol Chem 252: 7444–7446, 1977.
Ten Eick R, Nawrath H, McDonald TF, Trautwein W: On the negative inotropic effect of acetylcholine. Pflügers ARch 361: 207–213, 1976.
Trautwein W: Generation and conduction of impulses in the heart as affected by drugs. Pharmacol Rev 15: 277–332, 1963.
Inoue D, Hachisu M, Pappano AJ: Acetylcholine increases resting membrane potassium conductance in atrial but not ventricular muscle during muscarinic inhibition of Ca++-dependent action potentials in chick heart. Circ Res 53: 158–167, 1983.
Martin JM, Hunter DD, Nathanson NM: Islet activating protein inhibits physiological responses evoked by cardiac muscarinic acetylcholine receptors. Role of guanosine triphosphate binding proteins in regulation of potassium permeability. Biochemistry 24: 7521–7525, 1985.
Breitwieser G, Szabo G: Uncoupling of cardiac muscarinic and ß-adrenergic receptors from ion channels by a guanine nucleotide analogue. Nature 317: 538–540, 1985.
Pfaffinger PJ, Martin JM, Hunter DD, Nathanson NM, Hille B: GTP-binding proteins couple cardiac muscarinic receptors to a K channel. Nature 317: 536–538, 1985.
Kurachi Y, Nakajima T, Sugimoto T: Acetylcholine activation of K+ channels in cell-free membrane of atrial cells. Am J Physiol 251: H681–H684, 1986.
Yatani A, Codina J, Brown AM, Birnbaumer L: Direct activation of mamalian atrial muscarinic potassium channels by GTP regulatory protein Gk. Science 235: 207–211, 1987.
Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE: The ßy subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature 325: 321–326, 1987.
Goldberg ND, Haddox MK: Cyclic GMP metabolism and involvement in biological regulation. Ann Rev Biochem 46: 823–896, 1977.
Linden J, Brooker G: The questionable role of cyclic guanosine 3’: 5’— monophosphate in heart. Biochem Pharmacol 28: 3351–3360, 1979.
Krause EG, Halle W, Wollenberger A: Effect of direct dibutyryl cyclic GMP on cultured beating rat heart cells. Adv Cyclic Nucleotide Res 1: 301–305, 1972.
Tuganowski W, Kopec P, Kopyta M, Wezowska J: Iontophoretic application of autonomic mediators and cyclic nucleotides in sinus node cells. Naunyn-Schmiedeberg’s Arch Pharmacol 299: 65–67, 1977.
Kohlhardt M, Haap K: 8-bromo-guanosine-3’,5’-monophosphate mimics the effect of acetylcholine on slow response action potential and contractile force in mammalian atrial myocardium. J Mol Cell Cardiol 10: 573–586, 1978.
Nawrath H: Does cyclic GMP mediate the negative inotropic effect of acetylcholine in the heart? Nature 267: 72–74, 1977.
Watanabe AM, Besch HR Jr: Interaction between cyclic adenosine monophosphate and cyclic guanosine monophosphate in guinea pig ventricular myocardium. Circ Res 37: 309–317, 1975.
Watanabe AM, Hathaway DR, Besch HR Jr: Mechanism of cholinergic antagonism of the effects of isoproterenol on hearts from hyperthyroid rats. In: Kobayashi T, Sano T, Dhalla N (eds) Recent Advances in Studies on Cardiac Structure and Metabolism, Vol 11. Baltimore: University Park Press, 1978, pp 423–429.
Ong SH, Steiner AL: Localization of cyclic GMP and cyclic AMP in cardiac and skeletal muscle: Im-munocytochemicaldemonstration. Science 195:183–185, 1977.
Mirro MJ, Harper JF, Steiner AL: Compartmentation of cGMP in sinus node: Subcellular localization by immunocytochemistry. Circulation 62: III-239, 1980.
Lincoln TM, Keely SL: Regulation of the cardiac cyclic GMP-dependent protein kinase. Biochem Biophys Acta 676: 230–244, 1981.
Mirro MJ, Bailey JC, Watanabe AM: Dissociation between the electrophysiological properties and total tissue cyclic GMP content of guinea pig atria. Circ Res 45: 225–233, 1979.
Pappano AJ, Hartigen PM, Coutu MD: Acetylcholine inhibits the positive inotropic effect of cholera toxin in ventricular muscle. Am J Physiol 243: H434–H441, 1982.
Revtyak G, Jones LR, Watanabe AM, Besch HR Jr: Canine myocardial guanylate cyclase: Differential activation of sarcolemmal and cytoplasmic forms. Pharmacologist 20: 147, 1978.
Lindemann JP, Besch HR Jr, Watanabe AM: Indirect and direct effects of the divalent cation inophore A23187 on guinea pig and rat ventricular myocardium. Circ Res 44: 472–482, 1979.
Wallach F, Pastan I: Stimulation of membranous guanylate cyclase by concentrations of calcium that are in the physiological range. Biochem Biophys Res Commun 72: 859–865, 1976.
Quist E: Evidence for a carbachol stimulated phosphatidylinositol effect in heart. Biochem Pharmacol 31: 3130–3133, 1982.
Brown SL, Brown JH: Muscarinic stimulation of phosphatidylinositol metabolism in atria. Mol Pharmacol 24: 351–356, 1983.
Brown JH, Buxton IL, Brunton LL: (Xi-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes. Circ Res 57: 532–537, 1985.
Brown JH, Brown SL: Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinösitide metabolism. J Biol Chem 259: 3777–3781, 1984.
Brown BS, Poison JB, Krzanowski JJ, Wiggins JR: Influence of isoproterenol and methylisobutylxanthine on the contractile and cyclic nucleotide effects of methancholine in isolated rat atria. J Pharmacol Exp Ther 212: 325–332, 1980.
Bailey JC, Watanabe AM, Besch HR Jr, Lathrop DR: Acetylcholine antagonism of the electrophysiological effects of isoproterenol on canine cardiac Purkinje fibers. Circ Res 44: 378–383, 1979.
Inui J, Imamura H: Effects of acetylcholine on calcium-dependent electrical and mechanical response in the guinea-pig papillary muscle partially depolarized by potassium. Naunyn-Schmiedeberg’s Arch Pharmacol 299: 1–7, 1977.
Hescheler J, Kameyama M, Trautwein W:On the mechanism of muscarinic inhibition of the cardiac Ca current. Pfiugers Arch 407: 182–189, 1986.
Hartzell HC, Fischmeister R: Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells. Nature 323: 273–275, 1986.
Gardner RM, Allen DO: The relationship between cyclic nucleotide levels and glycogen Phosphorylase in isolated rat hearts perfused with epinephrine and acetylcholine. J Pharmacol Exp Ther 202: 346–353 1977.
Murad F, Chi YM, Rail TW, Sutherland EW: Adenyl cyclase. J Biol Chem 237: 1233–1238, 1962.
La Raia PJ, Sonnenblick EH: Autonomic control of cardiac cAMP. Circ Res 28: 377–384, 1971.
Meester WD, Hardman HF: Blockade of the positive inotropic actions of epinephrine and theophylline by acetylcholine. J Pharmacol Exp Ther 158: 241–247, 1967.
Biegon RL, Epstein PM, Pappano AJ: Muscarinic antagonism of the effects of a phosphodiesterase inhibitor (methylisobutylxanthine) in embryonic chick ventricle. J Pharmacol Exp Ther 215: 348–356, 1980.
Keely SL Jr, Lincoln TM, Corbin JD: Interaction of acetylcholine and epinephrine on heart cyclic AMP-dependent protein kinase. Am J Physiol 234: H432–H438, 1978.
Lindemann JP, Watanabe AM: Muscarinic cholinergic inhibition of ß-adrenergic stimulation of phospholamban phosphorylation and Ca2+- transport in guinea pig ventricles. J Biol Chem 260: 13122–13129, 1985.
Iwasa Y, Hosey MM: Cholinergic antagonism of ß-adrenergic stimulation of cardiac membrane protein phosphorylation in situ. J Biol Chem 258: 4571–4575, 1983.
Manalan, AS, Besch HR Jr, Watanabe AM: Characterization of [3H] (±) Carazolol binding to ß-adrenergic receptors: Application to study of ß-adrenergic receptor subtypes in canine ventricular myocardium and lung. Circ Res 49: 326–336, 1981.
Mirro MJ, Manalan AS, Bailey JC, Watanabe AM: Anticholinegic effects of disopyramide and quinidine on guinea pig myocardium: Mediation by direct muscarinic receptor blockade. Circ Res 47: 855–865, 1980.
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Lindemann, J.P., Watanabe, A.M. (1989). Mechanisms of Adrenergic and Cholinergic Regulation of Myocardial Contractility. In: Sperelakis, N. (eds) Physiology and Pathophysiology of the Heart. Developments in Cardiovascular Medicine, vol 90. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0873-7_20
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