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Developmental Changes in Alpha-Adrenergic Modulation of Cardiac Rhythm

  • Chapter
Physiology and Pathophysiology of the Heart

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 90))

Abstract

Until relatively recently, the role of the autonomic nervous system in the control of cardiac rhythm was thought to be rather straightforward {l}. The parasympathetic nervous system and its mediator, acetylcholine, were thought to exert an inhibitory function (depressing automaticity and atrioventricular conduction), and the sympathetic nervous system, along with epinephrine and norepinephrine, were thought to be excitatory, enhancing automaticity and speeding atrioventricular conduction. In the context of cardiac rhythm modulation, per se, the important sympathetic actions were thought to be beta adrenergic; only a minor role — if any — was consigned to the alpha adrenergic system. The major complicating factor in the picture was that of accentuated antagonism, whereby the parasympathetic limb of the autonomic system was shown to have enhanced effects in the presence of preexisting sympathetic tone {l, 2}.

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Authors
  1. Michael R. Rosen
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  2. Richard B. Robinson
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  3. Ira S. Cohen
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  4. John P. Bilezikian
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Editors and Affiliations

  1. Department of Physiology and Biophysics and College of Medicine, University of Cincinnati, 231 Bethesda Avenue, 45267-0579, Cincinnati, OH, USA

    Nicholas Sperelakis

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© 1989 Kluwer Academic Publishers

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Rosen, M.R., Robinson, R.B., Cohen, I.S., Bilezikian, J.P. (1989). Developmental Changes in Alpha-Adrenergic Modulation of Cardiac Rhythm. In: Sperelakis, N. (eds) Physiology and Pathophysiology of the Heart. Developments in Cardiovascular Medicine, vol 90. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0873-7_19

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  • DOI: https://doi.org/10.1007/978-1-4613-0873-7_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8222-8

  • Online ISBN: 978-1-4613-0873-7

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