Clinical Aspects of Hemodialysis Biocompatibility
Bioincompatibility of the hemodialysis extracorporeal circuit occurs primarily through one of several mechanisms: (a) cell adhesion, aggregation and activation; (b) transformation and adsorption of noncellular elements such as proteins; (c) mechanical shear; and (d) leaching and spallation of substances (1). Many substances are produced in the hemodialysis circuit which have theoretical biological effects. Whether these substances in fact lead to the theoretical effects, however, depend on a number of other factors: the timing and location of the production of the substances as well as the thresholds for the potential consequential events.
KeywordsDialysis Patient Hemodialysis Patient Complement Activation Ethylene Oxide Cellulosic Dialysis Membrane
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