Intradialytic Behaviour of β-2-Microglobulin During Acetate Dialysis (HDac), Biofiltration (BF) and Paired Filtration Dialysis (PFD)

Abstract

Literature data report the presence of a like-amyloid substance in the tendons, synovias and in the bones of the patients undergoing long term dialytic treatment (1,2,3,4). The β-2-microglobulin, produced by lynphoid cells and by the mastocytes when the blood comes into contact with the dialytic membranes, was identified as the most important component of the like-amyloid substance. Many autors (1,2,3,4) refer that the above substance plays a negative role on the bones allegation progression of the dialyzed patients and it may be considered as an index of the adequate dialysis. The above considerations and the introduction of the PFD among the new dialytic strategies, suggested us to carry a study on the intradialytic behaviour of β-2-microglobulin during standard haemodialytic treatment using cuprophan membranes during BF and during PFD using respectively AN 69 S and Cuprophan associated to Polisulphone membranes.