Cyclosporine Effect on Corticoresistant Nephrotic Syndrome in Primary Glomerulonephritis
Cyclosporine (CsA) efficacy in nephrotic syndrome (NS) from primary glomerulonephritis (GN) other than minimal changes GN is still controversial (1); moreover CsA has been generally employed at high doses and / or associated to steroids (2, 3). Its interference with lymphokines more than haemodynamic effect has been emphasized (4, 5). In order to test CsA efficacy in NS and in the attempt to avoid dose-related or steroid associated side effects, we started an open self-controlled therapeutic trial with low-dose CsA alone.
KeywordsNephrotic Syndrome Haemodynamic Effect Early Relapse Primary Glomerulonephritis Haemodynamic Mechanism
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