Abstract
P “pulses” are often used as a first therapeutic step in clinical transplantation, in autoimmune diseases and proteinuric nephropathies. Conflicting observations have been published on nonimmunologic effects of steroids on renal hemodynamics, tubular transports, and proteinuria increase or fluctuation which, however, does not necessarily mean resistance to treatment. The study was undertaken to evaluate, in patients with nephrotic syndrome, the acute effects of P on the following: urinary flow rate (V), renal plasma flow (RPF), filtration fractions (FF), endogenous creatinine clearance (CrCl), fractional clearances (FCl) of sodium (Na), potassium (K), albumin (Alb), transferrin (TF) and immunoglobulin G (IgG), urinary excretion of Thromboxane B2 (UTxB2), quantitative and qualitative urinary protein excretion.
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© 1989 Kluwer Academic Publishers
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Paternoster, G., Bionda, A., Caporali, N., Panichi, V., Palla, R. (1989). Acute Renal Effects of Intravenous High Dose Methylprednisolone (P) Therapy in Nephrotic Syndromes. In: Andreucci, V.E., Dal Canton, A. (eds) Current Therapy in Nephrology. Developments in Nephrology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0865-2_20
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DOI: https://doi.org/10.1007/978-1-4613-0865-2_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8209-9
Online ISBN: 978-1-4613-0865-2
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