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A Cellular Mechanism for Cyclosporine A-Induced Nephrotoxicity

  • H. Meyer-Lehnert
  • R. W. Schrier
Part of the Developments in Nephrology book series (DINE, volume 24)

Abstract

The immunosuppressive agent cyclosporine A (CyA) has been successfully used in organ transplantation and in the treatment of autoimmune diseases. A problem in CyA-therapy, however, is its nephrotoxicity (1) which is associated with a marked fall of glomerular filtration rate.

Keywords

Mesangial Cell Renal Vascular Resistance Glomerular Mesangial Cell Filtration Area Augmentory Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • H. Meyer-Lehnert
    • 1
  • R. W. Schrier
    • 2
  1. 1.Med. Univ.-Poliklinik BonnWest Germany
  2. 2.Univ. of Colorado Sch. Med.DenverUSA

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