A Cellular Mechanism for Cyclosporine A-Induced Nephrotoxicity
The immunosuppressive agent cyclosporine A (CyA) has been successfully used in organ transplantation and in the treatment of autoimmune diseases. A problem in CyA-therapy, however, is its nephrotoxicity (1) which is associated with a marked fall of glomerular filtration rate.
KeywordsMesangial Cell Renal Vascular Resistance Glomerular Mesangial Cell Filtration Area Augmentory Effect
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