A Cellular Mechanism for Cyclosporine A-Induced Nephrotoxicity

  • H. Meyer-Lehnert
  • R. W. Schrier
Part of the Developments in Nephrology book series (DINE, volume 24)


The immunosuppressive agent cyclosporine A (CyA) has been successfully used in organ transplantation and in the treatment of autoimmune diseases. A problem in CyA-therapy, however, is its nephrotoxicity (1) which is associated with a marked fall of glomerular filtration rate.


Mesangial Cell Renal Vascular Resistance Glomerular Mesangial Cell Filtration Area Augmentory Effect 
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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • H. Meyer-Lehnert
    • 1
  • R. W. Schrier
    • 2
  1. 1.Med. Univ.-Poliklinik BonnWest Germany
  2. 2.Univ. of Colorado Sch. Med.DenverUSA

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