HLA Class II Histoglobulins Involvement in Mesangial IgA Glomerulonephritis (Berger’s Disease)
Berger’s disease is characterized by mesangial granular deposits of IgA, with or without other immunoglobulin or complement protein deposits, and no evidence of systemic diseases. This form of glomerulonephritis has an unclear pathogenesis, but it is considered to be the consequence of immunological injuries. The diagnosis is based on the immunofluorescent examination of renal biopsy, laboratory data, and clinical findings. HLA histoglobulin frequency data, available from several studies, show that B35 (1,2) and B12 (3,4) seem to have a significant association with this disease. Fauchet (5) reported a statistical decrease of the DR3 frequency among the Berger’s patients. However, there is evidence of heterogeneity in these data: multiple reports from Japanese (6,7,8) and French (9,10) investigators show also a positive association with HLA-DR4 antigen.
KeywordsRenal Biopsy Plasma Creatinine Macroscopic Hematuria Phenotype Frequency Capillary Basement Membrane
Unable to display preview. Download preview PDF.
- 10.Le Pogamp, P., Chevet, D. and Simon, P. Néphrologie 2: 43, 1981.Google Scholar