Advertisement

Sandimmun®/An Appraisal of Drug Interactions

  • I. T. R. Cockburn
  • P. Krupp
Part of the Developments in Nephrology book series (DINE, volume 24)

Abstract

During the last five years many papers have been published summarising the more significant drug interactions observed with the use of Sandimmun (Cs) in animals and man (1–9). The Drug Monitoring Centre (DMC) of Sandoz Basle has monitored all information concerning this topic. Sources of data are the medical literature, the on-going post-marketing surveillance (PMS) study and spontaneous reports. Although the exact mechanisms for many interactions reported for Cs are still not understood, at least some can be explained either by alterations in absorption, metabolism or elimination or from deviation of expected pharmacological effects. The clinical outcome may vary from a minor disturbance requiring dose adjustment to more major consequences including nephrotoxicity or graft rejection. This paper summarises the results from this compilation.

Keywords

High Pressure Liquid Chromatography Concomitant Administration Transplant Proc Spontaneous Report Gingival Hyperplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    AJ Wood, G Maurer, W Niederberger et al.Transplant Proc 1982; 14: 659Google Scholar
  2. 2.
    LE Kerr. Clin Pharm 1984; 3:346PubMedGoogle Scholar
  3. 3.
    PA Keown, CR Stiller, M Stawecki et al. In: “Cyclosporin in Autoimmune Diseases”, 1st International Symposium, Basle (CH), 18–20 March 1985 Editor: R. Schindler. Publ: Springer-Verlag, Berlin, Heidelberg, New York, Tokyo 1985; 39–42Google Scholar
  4. 4.
    Anonymous Editorial. Pharmacy International, February 1986; 31–32Google Scholar
  5. 5.
    PH Whiting, MD Burke, AW Thomson. Transplant Proc 1986; 18(suppl 5): 56–70PubMedGoogle Scholar
  6. 6.
    ITR Cockburn. Transplant Proc 1986; 18(suppl 5): 50–55PubMedGoogle Scholar
  7. 7.
    J Grevel. In: “Ciclosporin in Renal Transplantation”, International Workshop on Ciclosporin in Renal Transplantation, Milan (I), 25–26 October 1985. Editor: C Ponticell, A De Vecchi. Publ: Karger, Basel, München, Paris, London, New York, New Delhi, Singapore, Tokyo, Sidney 1986; 23–30Google Scholar
  8. 8.
    A Orfila, L Lloveras, M Mir et al. Kidney Int 1987; 32:610CrossRefGoogle Scholar
  9. 9.
    NK Wadhwa, TJ Schroeder, AJ Pesce et al. Ther Drug Monit 1987; 9: 399–406PubMedCrossRefGoogle Scholar
  10. 10.
    T Beveridge, A Gratwohl, F Michot et al. Curr Ther Res 1981; 30: 5Google Scholar
  11. 11.
    G Burckhart, T Starzl, L Williams et al. Transplant Proc 1985; 17: 1172Google Scholar
  12. 12.
    J Grevel, E Nuesch, E Abisch et al. Europ J clin Pharmacol 1986; 31: 211–216CrossRefGoogle Scholar
  13. 13.
    R Venkataramanan, R Ptachinski, G Burckhart et al. J Clin Pharmacol 1984; 24: 528PubMedGoogle Scholar
  14. 14.
    PA Keown, A Laupacis, G Carruthers et al. Transplantation 1984; 38: 304–5PubMedGoogle Scholar
  15. 15.
    B Bourbigot, J Guiserix, J Airiau et al. Lancet 1986; i: 1447CrossRefGoogle Scholar
  16. 16.
    M Kessler, E Renoult, B Jonon et al. Therapie 1987; 42: 273–5PubMedGoogle Scholar
  17. 17.
    M Cantarovich, C Hiesse, F Lockiec et al. Clin Nephrol 1987; 28: 190–3PubMedGoogle Scholar
  18. 18.
    A Lindholm, S Henricsson. Lancet 1987; i: 1262–3CrossRefGoogle Scholar
  19. 19.
    HH Neumayer, K Wagner. Lancet 1986; ii: 523CrossRefGoogle Scholar
  20. 20.
    JM Grino, I Sabate, AM Castelao et al. Lancet 1986; i: 1387CrossRefGoogle Scholar
  21. 21.
    JM Pochet, Y Pirson. Lancet 1986; i: 979CrossRefGoogle Scholar
  22. 22.
    U Kunzendorf, G Walz, HH Neumayer et al. Klin Wschr 1987; 65:1101–3PubMedCrossRefGoogle Scholar
  23. 23.
    L Ost. Transplantation 1987; 44: 533–5PubMedCrossRefGoogle Scholar
  24. 24.
    RJ Ptachinski, R Venkataramanan, GJ Burckhart. Transplant Proc 1987; 19(1): 1728–9Google Scholar
  25. 25.
    FJ Frey, A Schnetzer, FF Horber et al. Transplantation 1987; 43:494–8PubMedCrossRefGoogle Scholar
  26. 26.
    TK Daneshmend. Lancet 1982; ii: 1217Google Scholar
  27. 27.
    H Dieperink, J Moller. Lancet 1982; ii: 1217CrossRefGoogle Scholar
  28. 28.
    RM Ferguson, DER Sutherland, RL Simmons et al. Lancet 1982; ii: 882–3CrossRefGoogle Scholar
  29. 29.
    C Cunningham, MD Burke, PH Whiting et al. Lancet 1982; i: 1464CrossRefGoogle Scholar
  30. 30.
    DJG White, NR Blatchford, G Cauwenbergh. Transplantation 1984; 37(2): 214–5PubMedCrossRefGoogle Scholar
  31. 31.
    JH Shepard, RL Simmons, JS Najarian. Clin Pharm 1986; 5: 468PubMedGoogle Scholar
  32. 32.
    JM Smith. Clin Sci 1983; 64: 678–9Google Scholar
  33. 33.
    TJ Schroeder, DB Melvin, CW Clardy et al. J Heart Transplant 1987; 6: 84–9PubMedGoogle Scholar
  34. 34.
    JE Anderson, RE Morris, TF Blaschke. Clin Res 1987; 35: 115AGoogle Scholar
  35. 35.
    RJ Ptachinski, BJ Carpenter, GJ Burckhart et al. New Engl J Med 1985; 313: 1416–7Google Scholar
  36. 36.
    M Hourmant, JF Le Bigot, L Vernillet et al. Transplant Proc 1985; 17: 2723–7Google Scholar
  37. 37.
    JRP Godin, IS Sketris, P Belitsky. Drug Intelligence and Clin Pharm 1986; 20: 504–5Google Scholar
  38. 38.
    RC Venuto, BM Murray, L Edwards et al. Kidney Int 1986; 29: 438Google Scholar
  39. 39.
    DE Kohan. New Engl J Med 1986; 314:448PubMedGoogle Scholar
  40. 40.
    R Martell, D Heinrichs, CR Stiller et al. Ann intern Med 1986; 104: 660–1PubMedGoogle Scholar
  41. 41.
    TA Gonwa, DD Nghiem, JA Schulak et al. Transplantation 1986; 41:797–9PubMedCrossRefGoogle Scholar
  42. 42.
    M Kessler, J Louis, E Renoult et al. Europ J clin Pharmacol 1986; 30: 633–4CrossRefGoogle Scholar
  43. 43.
    DJ Freeman, R Martell, SG Carruthers et al. Clin Pharmacol Ther 1986; 39:193Google Scholar
  44. 44.
    FY Aoki, R Yatscoff, J Jeffery et al. Clin Pharmacol Ther 1987; 41: 221Google Scholar
  45. 45.
    JD Harnett, PS Parfrey, MD Paul et al. Transplantation 1987; 43(2): 316–8PubMedCrossRefGoogle Scholar
  46. 46.
    NK Wadhwa, TJ Schroeder, EO O’Flaherty. Ther Drug Monit 1987; 9: 123–5PubMedCrossRefGoogle Scholar
  47. 47.
    P Vereerstraeten, P Thiry, P Kinnaert et al. Transplantation 1987; 44: 155–6PubMedCrossRefGoogle Scholar
  48. 48.
    C Kreft-Jais, EM Billaud, C Gaudry et al. Europ J Clin Pharmacol 1987; 32: 327–328CrossRefGoogle Scholar
  49. 49.
    G Leimenstoll, P Jessen, P Zabel et al. Deutsch Medizin Wschr 1984; 109:1989–90Google Scholar
  50. 50.
    G Deray, P Le Hoang, P Cacoub et al. Lancet 1987; i: 158–9CrossRefGoogle Scholar
  51. 51.
    WB Ross, D Roberts, PJA Griffin. Lancet 1986; i: 330CrossRefGoogle Scholar
  52. 52.
    BB Moller, B Ekelund. New Engl J Med 1985; 313: 1416PubMedGoogle Scholar
  53. 53.
    H Carstensen, N Jacobsen, H Dierpink. Brit J clin Pharmacol 1986; 21: 550–1Google Scholar
  54. 54.
    Anonymous. Pharm Int 1986; 7(II): 269–70Google Scholar
  55. 55.
    G. Hillebrand, LA Castro, W Van Scheidt et al. Transplantation 1987; 43:915–6PubMedGoogle Scholar
  56. 56.
    PA Keown, CA Stiller, AL Laupacis et al. Transplant Proc 1982; 14: 659–61PubMedGoogle Scholar
  57. 57.
    M Rowland, SK Gupta. Brit J clin Pharmacol 1987; 24: 329–34Google Scholar
  58. 58.
    P Lele, P Peterson, S Yang et al. Kidney Int 1985; 27:344Google Scholar
  59. 59.
    SA Veremis, MS Maddus, R Pollak et al. Transplantation 1987; 43: 913–5PubMedGoogle Scholar
  60. 60.
    GD Qureshi, TP Reinders, GJ Somori et al. Ann Intern Med 1984; 100: 527PubMedGoogle Scholar
  61. 61.
    E Langhoff, S Madsen. Lancet 1983; ii: 1031CrossRefGoogle Scholar
  62. 62.
    NJ Daniels, JS Dover, RK Schacter. Lancet 1984; ii: 639CrossRefGoogle Scholar
  63. 63.
    P Howard, TJ Bixler, B Gill. Drug Intell Clin Pharm 1985; 19: 763–4PubMedGoogle Scholar
  64. 64.
    G Offermann, F Keller, M Molzahn. Amer J Nephrol 1985; 5: 385–7CrossRefGoogle Scholar
  65. 65.
    MJD Cassidy, R van Zyl-Smit, MD Pascoe et al. Nephron 1985; 41:207–8PubMedCrossRefGoogle Scholar
  66. 66.
    J Wallwork, CGA McGregor, FC Wells et al. Lancet 1983; i: 366–7CrossRefGoogle Scholar
  67. 67.
    DK Jones, M Hakim, J Wallwork. Brit med J 1986: 292:728–9CrossRefGoogle Scholar
  68. 68.
    PF D’Arcy. Pharm Int 1986; 7: 138Google Scholar
  69. 69.
    JM Hows, S Palmer, S Want et al. Lancet 1981; ii:145–6CrossRefGoogle Scholar
  70. 70.
    A Termeer, AJ Hoitsma, RAP Koene. Transplantation 1986; 42: 220–1 35(3): 211–5PubMedGoogle Scholar
  71. 71.
    MS Kennedy, HJ Deeg, M Siegel et al. Transplantation 1983: 35(3): 211–5.CrossRefGoogle Scholar
  72. 72.
    GR Morgenstern, R Powles, B Robinson et al. Lancet 1982; ii: 1342CrossRefGoogle Scholar
  73. 73.
    JF Thompson, DHK Chalmers, AGW Hunnisett et al. Transplantation 1983; 36(2): 204–6PubMedCrossRefGoogle Scholar
  74. 74.
    G Nyberg, H Gäbel, P Althoff et al. Lancet 1984; i: 394–5CrossRefGoogle Scholar
  75. 75.
    O Ringden, P Myrenfors, G Klintmalm et al. Lancet 1984; i:1016–7CrossRefGoogle Scholar
  76. 76.
    AA Shaftie, LL Widdup, MA Abate et al. Drug Intell Clin Pharm 1986; 20(7): 602–5Google Scholar
  77. 77.
    MD Paul, PS Parfrey, M Smart et al. Amer J Kidney Dis 1987; 10(2): 133–5Google Scholar
  78. 78.
    DS Snyder. Ann intern Med 1988; 108:311Google Scholar
  79. 79.
    D Freeman, A Laupacis, P Keown et al. Ann R Coll Physicians Surg can 1984; 17(4):301Google Scholar
  80. 80.
    J Zazgornik, J Schindler, F Gremmel et al. Kidney Int 1985; 28:401Google Scholar
  81. 81.
    M Jarowenko, CT Van Buren, WC Kramer et al. Transplantation 1986 42:311–2PubMedCrossRefGoogle Scholar
  82. 82.
    J Zazgornik, W Schein, K Heimberger et al. Clin Nephrol 1986; 26: 265–6PubMedGoogle Scholar
  83. 83.
    B Sido, C Hammer, W Mraz et al. Transplant Proc 1987; 19(1): 1755–8PubMedGoogle Scholar
  84. 84.
    MA Shaw, M Gumbleton, PJ Nichols. Lancet 1987; ii:637CrossRefGoogle Scholar
  85. 85.
    D Trenk, W Brett, E Jahnchem et al. Lancet 1987; ii: 1335–6CrossRefGoogle Scholar
  86. 86.
    I Novakova, P Donelly, T de Witte et al. Lancet 1987; ii:920–1CrossRefGoogle Scholar
  87. 87.
    NK Wadhwa, TH Schroeder, EO O’Flaherty et al. Transplantation 1987; 43: 211–3.PubMedCrossRefGoogle Scholar
  88. 88.
    R Garraffo, B Monnier, P Lapalus et al. Med Sci Res 1987; 15:461Google Scholar
  89. 89.
    MK Chan. In: “Proceedings”, 2nd Asian Cyclosporin Workshop, Hong Kong 12–13 April 1986. Editor: BD Kahan. Publ: Excerpta Medica, Amsterdam, Hong Kong, Princeton, Sydney, Tokyo 1986; 38–40Google Scholar
  90. 90.
    L Rosenberg, DC Dafoe, R Schwartz et al. Transplantation 1987; 43: 764–6PubMedCrossRefGoogle Scholar
  91. 91.
    T Van den Akker, R Benner, J Radl. Transplantation 1987; 44:724–5CrossRefGoogle Scholar
  92. 92.
    JB Dossetor, T Kovithavongs, M Salkie et al. Ann Roy Coll Physicians Surg Can 1984; 17:363Google Scholar
  93. 93.
    Anonymous Editorial. Ann Intern Med 1983; 99:851–4Google Scholar
  94. 94.
    A Erice, MC Jordan, BA Chace et al. J Amer med Ass 1987; 257: 3082–7CrossRefGoogle Scholar
  95. 95.
    BM Murray, MS Paller. Kidney Int 1986; 29:434Google Scholar
  96. 96.
    BE de Pauw, T de Witte, RM Janssen et al. Krankenhausarzt 1984; 57: 854–8Google Scholar
  97. 97.
    P Dorian, C Cardella, M Strauss et al. Transplant Proc 1987; 19(1):1825–7PubMedGoogle Scholar
  98. 98.
    G Nanni, SC Magalini, F Serino et al. Transplantation 1988; 45: 257PubMedGoogle Scholar
  99. 99.
    P Christensen, M Leski. Brit med J 1987; 294:578CrossRefGoogle Scholar
  100. 99.
    PH Whiting, C Cunningham, AW Thompson. Biochem Pharmacol 1984; 33: 1075PubMedCrossRefGoogle Scholar
  101. 101.
    O Kloke, R Osieka. Klin Wschr 1985; 63:1081–2PubMedCrossRefGoogle Scholar
  102. 102.
    G Deray, P Le Hoang, B Aupetit et al. Clin Nephrol 1987; 27:213–4PubMedGoogle Scholar
  103. 103.
    MA McMillen, RJ Tesi, WB Baumgarten et al. Transplantation 1986; 40: 444–6Google Scholar
  104. 104.
    RJ Tesi, J Hong, KMH Butt et al. Transplant Proc 1987; 19(1): 1382–4PubMedGoogle Scholar
  105. 105.
    MA McMillen, WK Baumgarten, HC Schaefer et al. Transplantation 1987; 44:395–401PubMedCrossRefGoogle Scholar
  106. 106.
    R Osieka, S Seeber, R Pannenbäcker et al. Cancer Chemother Pharmacol 1986; 18(3): 198–202PubMedCrossRefGoogle Scholar
  107. 107.
    S Suzuki, T Hijoka, I Sakakibara et al. Transplantation 1987; 43 (5): 743–4PubMedCrossRefGoogle Scholar
  108. 108.
    D Fas. M Shimizu, B Vayuvegula et al. J Allergy Clin Immunl 1988; 81(1): 199Google Scholar
  109. 109.
    P Hansten. Drug Interact News Letter 1984; 4: 29Google Scholar
  110. 110.
    JA Tobert. New Eng J Med 1988; 318:47–48CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • I. T. R. Cockburn
    • 1
  • P. Krupp
    • 1
  1. 1.Drug Monitoring CentreSandoz Ltd.BasleSwitzerland

Personalised recommendations