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Sandimmun®/An Appraisal of Drug Interactions

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Current Therapy in Nephrology

Part of the book series: Developments in Nephrology ((DINE,volume 24))

Abstract

During the last five years many papers have been published summarising the more significant drug interactions observed with the use of Sandimmun (Cs) in animals and man (1–9). The Drug Monitoring Centre (DMC) of Sandoz Basle has monitored all information concerning this topic. Sources of data are the medical literature, the on-going post-marketing surveillance (PMS) study and spontaneous reports. Although the exact mechanisms for many interactions reported for Cs are still not understood, at least some can be explained either by alterations in absorption, metabolism or elimination or from deviation of expected pharmacological effects. The clinical outcome may vary from a minor disturbance requiring dose adjustment to more major consequences including nephrotoxicity or graft rejection. This paper summarises the results from this compilation.

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Author information

Authors and Affiliations

  1. Drug Monitoring Centre, Sandoz Ltd., 4002, Basle, Switzerland

    I. T. R. Cockburn & P. Krupp

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  1. I. T. R. Cockburn
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  2. P. Krupp
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Editor information

Editors and Affiliations

  1. Department of Nephrology, University of Naples, Naples, Italy

    Vittorio E. Andreucci M.D.  & Antonio Dal Canton M.D.  & 

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© 1989 Kluwer Academic Publishers

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Cockburn, I.T.R., Krupp, P. (1989). Sandimmun®/An Appraisal of Drug Interactions. In: Andreucci, V.E., Dal Canton, A. (eds) Current Therapy in Nephrology. Developments in Nephrology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0865-2_135

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  • DOI: https://doi.org/10.1007/978-1-4613-0865-2_135

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8209-9

  • Online ISBN: 978-1-4613-0865-2

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