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Interleukin-2 Production and Abnormalities of Immune Regulation in Patients with Primary IgA Nephropathy

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Current Therapy in Nephrology

Part of the book series: Developments in Nephrology ((DINE,volume 24))

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Abstract

IgA nephropathy (IgAN) is characterized by the presence in the blood of increased IgA-specific helper T cell activity with the receptor for the Fc region of IgA (Tα cells) (1), decreased IgA-specific suppressor T cell activity (2) and increased number of peripheral B lymphocytes with IgA Fc receptor (Bα cells) (3). Since interleukin 2 (IL-2) is a polypeptidic hormone which plays an important role in immunoregulation and lymphocyte activation, we thought it opportune to study the production of IL-2 from peripheral blood mononuclear cells (PBMC) of patients with IgAN. Furthermore, we studied the distribution of IL-2R on PBMC surface.

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Authors and Affiliations

  1. Chair of Medical Therapy, University of Bari, Italy

    F. P. Schena, G. Mastrolitti, A. R. Fracasso & L. Aventaggiato

Authors
  1. F. P. Schena
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  2. G. Mastrolitti
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  3. A. R. Fracasso
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  4. L. Aventaggiato
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Editor information

Editors and Affiliations

  1. Department of Nephrology, University of Naples, Naples, Italy

    Vittorio E. Andreucci M.D.  & Antonio Dal Canton M.D.  & 

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© 1989 Kluwer Academic Publishers

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Schena, F.P., Mastrolitti, G., Fracasso, A.R., Aventaggiato, L. (1989). Interleukin-2 Production and Abnormalities of Immune Regulation in Patients with Primary IgA Nephropathy. In: Andreucci, V.E., Dal Canton, A. (eds) Current Therapy in Nephrology. Developments in Nephrology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0865-2_12

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  • DOI: https://doi.org/10.1007/978-1-4613-0865-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8209-9

  • Online ISBN: 978-1-4613-0865-2

  • eBook Packages: Springer Book Archive

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