Second-Generation Agents

  • Lionel H. Opie
  • William A. Coetzee


Second-generation agents include new dihydropyridines, such as amlodipine, felodipine, isradipine, nicardipine, nimodipine, nisoldipine, and nitrendipine. Verapamil-like agents include tiapamil, gallopamil, and anipamil. Among the diphenylalkylamines, bepridil is of special interest. New preparations of existing agents include slow-release formulations of nifedipine, verapamil, and diltiazem. From all these agents will be selected those that are longer-acting and provide higher vascular selectivity.


Congestive Heart Failure Angina Pectoris Calcium Antagonist Calcium Channel Antagonist Negative Inotropic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • Lionel H. Opie
    • 1
    • 2
  • William A. Coetzee
    • 3
  1. 1.University of Cape TownCape TownSouth Africa
  2. 2.Division of CardiologyStanford University Medical CenterStanfordUSA
  3. 3.Heart Research UnitUniversity of Cape TownSouth Africa

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