Carotenoids pp 293-300 | Cite as

β-Carotene Prevention of 7,12-Dimethylbenz [A] Anthracene-Induced Transformation of Mouse Mammary Cells In Vitro

  • K. Manoharan
  • S. Som
  • M. Chatterjee
  • M. R. Banerjee

Abstract

Epidemiological studies have suggested that β-carotene, a dietary vitamin A precursor, may influence reduced tumor incidence in human populations1. In contrast to the abundance of studies2,3 on the chemopreventive properties of retinoids (vitamin A analogues) little is known about the mode of action of β-carotene, the vitamin A precursor. Only a few preliminary reports based on rather indirect observations have indicated that a carrot rich diet or injections of β-carotene result in reduced tumor incidence in rats and mice treated with a carcinogenic chemicals and/or u.v. radiation4–6. These observations prompted the investigations of the chemopreventive role of β-carotene itself in an in vitro controlled environment, because in the animal the vitamin A precursor is metabolized to retinol.

Keywords

DMSO Cortisol Carotenoid Prolactin Cyclohexane 

Abbreviations

DMBA

7,12-dimethylbenz [a] anthracene

NLAL

nodule-like alveolar lesions

DMSO

dimethyl sulfoxide

HAN

hyperplastic alveolar nodules

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • K. Manoharan
    • 1
  • S. Som
    • 1
  • M. Chatterjee
    • 1
  • M. R. Banerjee
    • 1
  1. 1.Tumor Biology Laboratory, School of Biological SciencesUniversity of Nebraska-LincolnLincolnUSA

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