β-Carotene Prevention of 7,12-Dimethylbenz [A] Anthracene-Induced Transformation of Mouse Mammary Cells In Vitro
Epidemiological studies have suggested that β-carotene, a dietary vitamin A precursor, may influence reduced tumor incidence in human populations1. In contrast to the abundance of studies2,3 on the chemopreventive properties of retinoids (vitamin A analogues) little is known about the mode of action of β-carotene, the vitamin A precursor. Only a few preliminary reports based on rather indirect observations have indicated that a carrot rich diet or injections of β-carotene result in reduced tumor incidence in rats and mice treated with a carcinogenic chemicals and/or u.v. radiation4–6. These observations prompted the investigations of the chemopreventive role of β-carotene itself in an in vitro controlled environment, because in the animal the vitamin A precursor is metabolized to retinol.
KeywordsMammary Gland Singlet Oxygen Mammary Epithelial Cell Sister Chromatid Exchange Initiation Stage
7,12-dimethylbenz [a] anthracene
nodule-like alveolar lesions
hyperplastic alveolar nodules
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