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Animal Models

Chapter
Part of the The Depressive Illness Series book series (DISS, volume 2)

Abstract

In general, psychiatric conditions have been difficult to model in animals. Nonetheless, such modeling offers much in attempting to understand the conditions and stimuli that can give rise to the symptoms seen in psychiatric illnesses. Although it is unlikely that a complex human psychiatric illness can be fully reproduced in animals, it is by using animals that one can selectively study the behavioral effects caused by manipulating a single environmental variable. This can give us valuable clues in studying the etiological factors suggested by our different theoretical hypotheses concerning the origin of a disease such as depression. In fact, in the case of depression, two of the major theoretical positions have been extensively tested in animals. First, the idea that loss or separation plays a critical role in the development of depressive illness has been examined in primates in considerable detail. Second, the idea that depression has cognitive origins—that it represents a learned behavior—has been extensively studied in animals.

Keywords

Maternal Separation Learned Helplessness Inescapable Shock Separation Model Behavioral Despair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  1. 1.Department of Psychiatry, Health Sciences Center, School of MedicineSUNY at Stony BrookStony BrookUSA

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