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Depressive disorders are an illness. However, the search for a cause or causes and for an understanding of the pathogenesis involved is rendered difficult by the functional and structural complexity of the brain and, at the same time, its physical inaccessibility. Moreover, mental symptoms can be generated by both psychological and biological factors. The etiological role in depressive disorders of genetic factors, which must be expressed biologically and ultimately psychologically, is proven, but the pathogenesis is unknown. In contrast, the etiological role of psychological factors is unproven but much of the assumed psychopathogenesis is described.
KeywordsDepressive Disorder Attributional Style Depressive Illness Etiological Role Mental Symptom
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