Abstract
Inflammation and hyperalgesia are common components of many acute and chronic pain conditions including postsurgical acute pain, cancer pain and arthritis. Pathological changes in peripheral nerve produced by trauma, metabolic disorders or viral infections sometimes result in painful neuropathies characterized by spontaneous pain, hyperalgesia and allodynia. Experimental studies in which the effects of peripheral tissue inflammation are compared with the effects of nerve injury on neuronal responsiveness in the peripheral and central nervous systems should provide insights into our understanding of the pathophysiology associated with these acute and chronic pain conditions.
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References
AGUAYO, A.J., PEYRONNARD, J.M. AND BRAY, G.M. (1973). A quantitative ultrastructural study of regeneration from isolated proximal stumps of transected unmyelinated nerves. >Journal of Experimental Neurology 32, 256–270.
BENNETH, G.J. AND XIE, Y.-K. (1988). A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. >Pain 33, 87107.
BROWN, A.G., FYFFE, R.E.W., NOBLE, R. AND ROWE, M.J. (1984). Effects of hindlimb nerve section on lumbosacral dorsal horn neurones in the cat. >Journal of Physiology 354, 375–394.
CALVINO, B., VILLANUEVA, L. AND LEBARS, D. (1987). Dorsal horn (convergent) neurones in the intact anaesthetized arthritic rat. I. Segmental excitatory influences. >Pain 28, 81–98.
CAMPBELL, J.N., RAJA, S.N., MEYER, R.A. AND MACKINHON, S.E. (1988). Myelinated afferents signal the hyperalgesia associated with nerve injury. >Pain 32, 89–94.
COOK, A.J., WOOLF, C.J., WALL, P.D. AND MCMAHON, S.B. (1987). Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input. >Nature 325, 151–153.
DEVOR, M. (1984). The pathophysiology and anatomy of damaged nerve. In >Textbook of Pain, eds. WALL, P.D. and Melzack, M., pp. 49–64. Edinburgh: Churchill Livingstone.
DEVOR, M. AND CLAMAN, D. (1980). Mapping and plasticity of acid phosphatase afferents in the rat dorsal horn. >Brain >Research 190, 17–28.
DEVOR, M. AND WALL, P.D. (1981). Plasticity in the spinal cord sensory map following peripheral nerve injury in rats. >Journal of Neuroscience 1, 679684.
DOSTROVSKY, J.O., MILLAR, J. AND WALL, P.D. (1976). The immediate shift of afferent drive of dorsal column nucleus cells following deafferentation: a comparison of acute and chronic deafferentation in gracile nucleus and spinal cord. >Experimental Neurology 52, 480–495.
DUBNER, R., AND BENNETH, G.J. (1983). Spinal and trigeminal mechanisms of nociception. >Annual Review Neuroscience 6, 381–418.
DUBNER, R., SHARAV, Y., GRACELY, G.H. AND PRICE, D.D. (1987). Idiopathic trigeminal neuralgia: sensory features and pain mechanisms. >Pain 31, 23–33.
HARGREAVES, K., DUBNER, R., BROWN, F., FLORES, C. AND JORIS, J. (1988). A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. >Pain 32, 77–88.
HYLDEN, J.L.K., NAHIN, R.L. AND DUBNER, R. (1987). Altered responses of nociceptive cat lamina Ispinal dorsal horn neurons after chronic sciatic neuroma formation. >Brain Research 411, 341–350.
HYLDEN, J.L.K., NAHIN, R.L., TRAUB, R.J. AND DUBNER, R. (1989). Physiological characterization of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation, (submitted)
IADAROLA, M.J., DOUGLASS, J., CIVELLI, O. AND NARANJO, J.R. (1988). Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization. >Brain >Research, In press.
JANIG, W. (1988). Pathophysiology of nerve following mechanical injury. In >Proceedings of the Fifth World Congress on Pain, eds. DUBNER, R., GEBHART, G.F. AND BOND, M.R., pp. 89–108. Amsterdam: Elsevier.
KOCHER, L., ANTON, F., REEH, P.W. AND HANDWERKER, H.O. (1987). The effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in the rat. >Pain 29, 363–373.
LAMOTTE, R.H., THALHAMMER, J.G., TORBJÖRK, H.E. AND ROBINSON, C.J. (1982). Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. >Journal of Neuroscience 2, 765–781.
LISNEY, S.J.W. (1983). Changes in the somatotopic organization of the cat lumbar spinal cord following peripheral nerve transection and regeneration. >Brain >Research 259, 31–39.
MARKUS, H. AND POMERANZ, B. (1987). Saphenous has weak ineffective synapses in sciatic territory of rat spinal cord: electrical stimulation of the saphenous or application of drugs reveal these somatotopically inappropriate synapses. >Brain >Research 416, 315–321.
MCMAHON, S.B. AND WALL, P.D. (1984). Receptive fields of rat lamina Iprojection cells move to incorporate a nearby region of injury. >Pain 19, 235–247.
MENDELL, L.M., SASSOON, E.M. AND WALL, P.D. (1978). Properties of synaptic linkage from long ranging afferents onto dorsal horn neurons in normal and deafferented cats. >Journal >of >Physiology 285, 299–310.
MENÉTREY, D. AND BESSON, J.M. (1982). Electrophysiological characteristics of dorsal horn cells in rats with cutaneous inflammation resulting from chronic arthritis. >Pain 13, 343–364.
MERRILL, E.G. AND WALL, P.D. (1972). Factors forming the edge of a receptive field: the presence of relatively ineffective afferent terminals. >Journal of >Physiology 226, 825–846.
MILLAN, M.J., MILLAN, M.H., CZLONKOWSKI, A., HÖLLT, V., PILCHER, C.W.T., HERZ, A. and COLPAERT, F.C. (1986). A model of chronic pain in the rat: Response of multiple opioid systems to adjuvant-induced arthritis. >Journal >of >Neuroscience 6, 899–906.
OKU, R., SATOH, M., AND TAKAGI, H. (1987). Release of substance Pfrom the spinal dorsal horn is enhanced in polyarthritic rats. >Neuroscience >Letters 74, 315–319.
PUBOLS, L.M. (1984). The boundary of proximal hindlimb representation in the dorsal horn following peripheral nerve lesions in cats: a reevaluation of plasticity in the somatotopic map. >Somatosensory Research 2, 19–32.
PUBOLS, L.M., FOGLESONG, M.E. AND VAHLE-HLNZ, C. (1986). Electrical stimulation reveals relatively ineffective sural nerve projections to dorsal horn neurons in the cat. >Brain >Research 371, 109–122.
RAJA, S.N., CAMPBELL, J. AND MEYER, R. (1984). Evidence for different mechanisms of primary and secondary hyperalgesia following heat injury to the glabrous skin. >Brain 107, 1179–1188.
REEH, P.W., KOCHERr, L. AND JUNG, S. (1986). Does neurogenic inflammation alter the sensitivity of unmyelinated nociceptors in the rat? >Brain >Research 384, 42–50.
RODIN, E.B. AND KRUGER, L. (1984). Absence of intraspinal sprouting in dorsal root axons caudal to a partial spinal hemisection: a horseradish peroxidase transport study. >Somatosensory >Research 2, 171–192.
RODIN, E.B., SAMPOGNA, S.L. AND KRUGER, L. (1983). An examination of intraspinal sprouting in dorsal root axons with the tracer horseradish peroxidase. >Journal >of >Comparative >Neurology 215, 187–198.
RUDA, M.A., IADAROLA, M.J., COHEN, L.V. AND YOUNG III, W.S. (1988). >In situhybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia. >Proceedings National Academy of Science USA 85, 622–626.
RYU, P.D., GERBER, G., MURASE, K. AND RANDIC, M. (1988). Actions of calcitonin gene-related peptide on rat spinal dorsal horn neurons. >Brain >Research 441, 357–361.
SAADE, N., JABBUR, S.J. and WALL, P.D. (1985). Effects of 4-amino-pyridine, GAB A and bicuculline on cutaneous receptive fields of cat dorsal horn neurons. >Brain >Research 344, 356–359.
SCHAIBLE, H.-G. AND SCHMIDT, R.G. (1988). Direct observation of the sensitization of articular afferents during an experimental arthritis. In >Proceedings of the Fifth World Congress on Pain, eds. DUBNER, R., GEBHART, G.F. and Bond, M.R., pp. 44–50. Amsterdam: Elsevier.
SELTZER, Z. AND DEVOR, M. (1984). Effect of nerve section on the spinal distribution of neighboring nerves. >BrainRe>search 306, 31–37.
SNOW, P.J. AND WILSON, P. (1985). Plasticity of somatosensory maps in the adult mammalian spinal cord. >Society >Neuroscience >Abstract 11, 965.
URBAN, L. AND RANDIC, M. (1984). Slow excitatory transmission in rat dorsal horn: possible mediation by peptides. >Brain >Research 290, 336–341.
WALL, P.D. AND DEVOR, M. (1981). The effect of peripheral nerve injury on dorsal root potentials and on transmission of afferent signals into the spinal cord. >Brain >Research 209, 95–111.
WALL, P.D., FITZGERALD, M. AND GIBSON, S.J. (1981). The response of rat spinal cord cells to unmyelinated afferents after peripheral nerve section and after changes in substance P levels. >Neuroscience 6, 2205–2215.
YOKOTA, T. AND NISHIKAWA, Y. (1979). Action of picrotoxin upon trigeminal subnucleus caudalis neurons in the monkey. >Brain >Research 171, 369–373.
ZIMMERMAN, M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. >Pain 16,109110.
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Dubner, R., Hylden, J.L.K., Nahin, R.L., Traub, R.J. (1989). Neuronal Plasticity in the Superficial Dorsal Horn Following Peripheral Tissue Inflammation and Nerve Injury. In: Cervero, F., Bennett, G.J., Headley, P.M. (eds) Processing of Sensory Information in the Superficial Dorsal Horn of the Spinal Cord. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0825-6_43
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DOI: https://doi.org/10.1007/978-1-4613-0825-6_43
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