Neuronal Plasticity in the Superficial Dorsal Horn Following Peripheral Tissue Inflammation and Nerve Injury

  • R. Dubner
  • J. L. K. Hylden
  • R. L. Nahin
  • R. J. Traub

Abstract

Inflammation and hyperalgesia are common components of many acute and chronic pain conditions including postsurgical acute pain, cancer pain and arthritis. Pathological changes in peripheral nerve produced by trauma, metabolic disorders or viral infections sometimes result in painful neuropathies characterized by spontaneous pain, hyperalgesia and allodynia. Experimental studies in which the effects of peripheral tissue inflammation are compared with the effects of nerve injury on neuronal responsiveness in the peripheral and central nervous systems should provide insights into our understanding of the pathophysiology associated with these acute and chronic pain conditions.

Keywords

Arthritis Polyethylene Neuropathy Calcitonin Neuroma 

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • R. Dubner
    • 1
  • J. L. K. Hylden
    • 1
  • R. L. Nahin
    • 1
  • R. J. Traub
    • 1
  1. 1.Neurobiology and Anesthesiology Branch, National Institute of Dental ResearchNational Institutes of HealthBethesdaUSA

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