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Somatic, Articular and Visceral Noxious- Stimulus Evoked Expression of C-FOS in the Spinal Cord of the Rat: Differential Patterns of Activity and Modulation by Analgesic Agents

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Processing of Sensory Information in the Superficial Dorsal Horn of the Spinal Cord

Abstract

Recent years have seen a remarkable increase in our understanding of the anatomical circuitry through which noxious stimuli are presumed to access spinal cord, brainstem and thalamic structures. Many studies of the anatomy of pain processing mechanisms have addressed the distribution of primary afferent fibers, including the differential central projection of single nociceptive fibers which have been identified electrophysiologically. Those studies have demonstrated that there is a very dense projection to the superficial dorsal horn from Aδ and C fibers. Other studies have used retrograde tracing techniques to characterize the organization of ascending projection systems that arise from the dorsal and ventral horns. Still other studies have focused on the cytochemistry of the primary afferent and second order neurons and on the descending control systems that modulate their firing. Largely because of the high concentration of peptidergic cells and terminals in the superficial dorsal horn, EM immunocytochemical studies of peptide circuits have focused in that region. (For reviews see Basbaum and Fields, 1984; Besson and Chaouch, 1987)

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Authors and Affiliations

  1. Departments of Anatomy, Physiology, Medicine and Anesthesiology, University of California, San Francisco, CA, 94143, USA

    Allan I. Basbaum, Robert Presley, Daniel Menétrey, Shu-Ing Chi & Jon D. Levine

  2. INSERM U-161, 2, rue d’Alésia, 75014, Paris, France

    Allan I. Basbaum, Robert Presley, Daniel Menétrey, Shu-Ing Chi & Jon D. Levine

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  1. Allan I. Basbaum
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  2. Robert Presley
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  3. Daniel Menétrey
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  4. Shu-Ing Chi
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Editors and Affiliations

  1. University of Bristol Medical School, Bristol, UK

    F. Cervero

  2. National Institute of Dental Research National Institutes of Health, Bethesda, Maryland, USA

    G. J. Bennett

  3. University of Bristol Medical School, Bristol, UK

    P. M. Headley

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Basbaum, A.I., Presley, R., Menétrey, D., Chi, SI., Levine, J.D. (1989). Somatic, Articular and Visceral Noxious- Stimulus Evoked Expression of C-FOS in the Spinal Cord of the Rat: Differential Patterns of Activity and Modulation by Analgesic Agents. In: Cervero, F., Bennett, G.J., Headley, P.M. (eds) Processing of Sensory Information in the Superficial Dorsal Horn of the Spinal Cord. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0825-6_36

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  • DOI: https://doi.org/10.1007/978-1-4613-0825-6_36

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  • Print ISBN: 978-1-4612-8101-6

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