Guanidines 2 pp 313-322 | Cite as

Effect of Antibiotic Administration on Urinary Guanidinoacetic Acid Excretion in Renal Disease

  • Shuei Nakayama
  • Ikuo Kiyatake
  • Yoshio Shirokane
  • Hikaru Koide

Abstract

It is known that there is a marked decrease in urinary guanidinoacetic acid (GAA) excretion in patients with uremia1–3. We have previously reported that urinary GAA (U-GAA) excretion is significantly decreased in experimental animals injected with 20 to 50 mg/kg of gentamicin4. Our further study also showed that such a reduction in GAA excretion is seen even in animals injected with 5 mg/kg, a relatively small dose of gentamicin5. These findings have led some to suggest that GAA would be useful for the early diagnosis of antibiotic-induced nephrotoxicity.

Keywords

Urea Creatinine Toluene Cytosol Ampicillin 

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References

  1. 1.
    Bonas, J.E., Cohen, B.D., Natelson, S., Separation and estimation of certain guanidino compounds: Aplication to human urine, Microchem. J. 7 (1963) 63–77.Google Scholar
  2. 2.
    Cohen, B.D., Stein, I.M., Bonas, J.E., Guanidinosuccinic aciduria in uremia. A possible alternate pathway for urea synthsis, Am. J. Med. 45 (1968) 63–68.CrossRefGoogle Scholar
  3. 3.
    Koide, H., Azushima, C., Metabolic profiles of guanidino compounds in various tissues of uremic rats, in “Guanidines”, A. Mori, B.D. Cohen, A. Lowenthal Eds., Plenum Press, New York (1985) pp. 365–372.Google Scholar
  4. 4.
    Itabashi H. Rinno, H., Koide, H., Urinary guanidinoacetic acid excretion in gentamicin nephrotoxicity, in “Guanidines”, A. Mori, B.D. Cohen, A. Lowenthal Eds, Plenum Press, New York (1985) pp. 327–334.Google Scholar
  5. 5.
    Nakayama, S., Junen, M., Kiyatake, I., Koide, H., Urinary guanidinoacetic acid excretion as an indicator of gentamicin nephrotoxicity in the rats, (in this book) pp 303–311.Google Scholar
  6. 6.
    Shirokane, Y., Utsushikawa, M., Nakajima, M., A new enzymic determination of guanidinoacetic acid in urine, Clin. Chem. 33 (1987) 394–397.Google Scholar
  7. 7.
    Schweizer, R.T., Moore, R., Bartus, S.A., Bow, L., Hayden, J., Beta2 microglobulin monitoring after renal transplantation, Transplant. Proc. 13 (1981) 1620–1623.Google Scholar
  8. 8.
    Mondorf, A.W., Zegelman, M., et al., Comparative studies on the action of aminoglycosides and cephalosporins on the proximal tubule of the human kidney, Proceedings of the 10th International Congress of Chemotherapy, Zurich, 1977.Google Scholar
  9. 9.
    Proctor, R.A., Kunin, C.M., Salicylate-induced enzymuria, Am. J. Med., 65 (1978) 987–993.CrossRefGoogle Scholar
  10. 10.
    Beck, P.R., Thompson, R.B., Chadhuri, A.K.R., Aminoglycoside antibiotics and renal function: Changes in urinary glutamyltransferase excretion, J. Clin, Pathol., 30 (1977) 432–437.CrossRefGoogle Scholar
  11. 11.
    Wellwood, J.M., Lovell, D., Thompson. A.E., et al., Renal damage caused by gentamicin: A study of the effects on renal morphology and urinary enzyme excretion, J. Pathol., 118 (1976) 171–182.CrossRefGoogle Scholar
  12. 12.
    Walker, J.B., Formanidine group transfer in extracts of human pancreas, liver and kidney, Biochem. Biophys. Acta 73 (1963)241–247.Google Scholar
  13. 13.
    Gonick, H.C., Kramer, H.J., Schapiro, A.E., Urinary β-glucuronidase activity in renal disease, Arch. Intern. Med. 132 (1973) 63–69.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Shuei Nakayama
    • 1
  • Ikuo Kiyatake
    • 1
  • Yoshio Shirokane
    • 2
  • Hikaru Koide
    • 1
  1. 1.Division of Nephrology, Department of MedicineJuntendo University School of MedicineTokyoJapan
  2. 2.Bioscience Research LaboratoryKikkoman CorporationChibaJapan

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