Effect of Antibiotic Administration on Urinary Guanidinoacetic Acid Excretion in Renal Disease
It is known that there is a marked decrease in urinary guanidinoacetic acid (GAA) excretion in patients with uremia1–3. We have previously reported that urinary GAA (U-GAA) excretion is significantly decreased in experimental animals injected with 20 to 50 mg/kg of gentamicin4. Our further study also showed that such a reduction in GAA excretion is seen even in animals injected with 5 mg/kg, a relatively small dose of gentamicin5. These findings have led some to suggest that GAA would be useful for the early diagnosis of antibiotic-induced nephrotoxicity.
KeywordsMembranous Nephropathy High Performance Liquid Chromato Renal Histology High Performance Liquid Chromato Urinary Enzyme
Unable to display preview. Download preview PDF.
- 1.Bonas, J.E., Cohen, B.D., Natelson, S., Separation and estimation of certain guanidino compounds: Aplication to human urine, Microchem. J. 7 (1963) 63–77.Google Scholar
- 3.Koide, H., Azushima, C., Metabolic profiles of guanidino compounds in various tissues of uremic rats, in “Guanidines”, A. Mori, B.D. Cohen, A. Lowenthal Eds., Plenum Press, New York (1985) pp. 365–372.Google Scholar
- 4.Itabashi H. Rinno, H., Koide, H., Urinary guanidinoacetic acid excretion in gentamicin nephrotoxicity, in “Guanidines”, A. Mori, B.D. Cohen, A. Lowenthal Eds, Plenum Press, New York (1985) pp. 327–334.Google Scholar
- 5.Nakayama, S., Junen, M., Kiyatake, I., Koide, H., Urinary guanidinoacetic acid excretion as an indicator of gentamicin nephrotoxicity in the rats, (in this book) pp 303–311.Google Scholar
- 6.Shirokane, Y., Utsushikawa, M., Nakajima, M., A new enzymic determination of guanidinoacetic acid in urine, Clin. Chem. 33 (1987) 394–397.Google Scholar
- 7.Schweizer, R.T., Moore, R., Bartus, S.A., Bow, L., Hayden, J., Beta2 microglobulin monitoring after renal transplantation, Transplant. Proc. 13 (1981) 1620–1623.Google Scholar
- 8.Mondorf, A.W., Zegelman, M., et al., Comparative studies on the action of aminoglycosides and cephalosporins on the proximal tubule of the human kidney, Proceedings of the 10th International Congress of Chemotherapy, Zurich, 1977.Google Scholar
- 12.Walker, J.B., Formanidine group transfer in extracts of human pancreas, liver and kidney, Biochem. Biophys. Acta 73 (1963)241–247.Google Scholar