Guanidines 2 pp 313-322 | Cite as

Effect of Antibiotic Administration on Urinary Guanidinoacetic Acid Excretion in Renal Disease

  • Shuei Nakayama
  • Ikuo Kiyatake
  • Yoshio Shirokane
  • Hikaru Koide


It is known that there is a marked decrease in urinary guanidinoacetic acid (GAA) excretion in patients with uremia1–3. We have previously reported that urinary GAA (U-GAA) excretion is significantly decreased in experimental animals injected with 20 to 50 mg/kg of gentamicin4. Our further study also showed that such a reduction in GAA excretion is seen even in animals injected with 5 mg/kg, a relatively small dose of gentamicin5. These findings have led some to suggest that GAA would be useful for the early diagnosis of antibiotic-induced nephrotoxicity.


Membranous Nephropathy High Performance Liquid Chromato Renal Histology High Performance Liquid Chromato Urinary Enzyme 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Shuei Nakayama
    • 1
  • Ikuo Kiyatake
    • 1
  • Yoshio Shirokane
    • 2
  • Hikaru Koide
    • 1
  1. 1.Division of Nephrology, Department of MedicineJuntendo University School of MedicineTokyoJapan
  2. 2.Bioscience Research LaboratoryKikkoman CorporationChibaJapan

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