Guanidines 2 pp 225-231 | Cite as


  • Armand Lowenthal
  • Bart Marescau


In 1969 we published a paper concerning the first family with hyper-argininemia1. Describe once again the discovery of this disease seemed interesting. The first patient with hyperargininemia, a girl, was treated by Dr. Terheggen for epilepsy. Later, when her sister was brought to him for treatment also of epilepsy, he considered the possibility of a metabolic disease. An examination of the urine was carried out in one of the best biochemical laboratories in Germany. The answer was that the found cystinuria was irrelevant in a neurological metabolic disease with epilepsy and thus of no further interest.


Urea Cycle Hippuric Acid Sodium Benzoate Arginase Activity Orotic Acid 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Armand Lowenthal
    • 1
  • Bart Marescau
    • 1
  1. 1.Laboratory of NeurochemistryBorn-Bunge Foundation University of Antwerp (UIA), Universiteitsplein 1AntwerpBelgium

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