Urinary Excretion Rate of Guanidinoacetic Acid in Essential Hypertension
The kidney is one of the major target organs in hypertension. Longterm persistent hypertension causes nephrosclerosis pathologicaly in 70–90% of patients1–2. Concerning the laboratory findings correlated with this pathological change, urinary micro-albumin (mAlb), ß-2-microglobuline (RMG) and N-acetyl-D-glucosaminidase (NAG) have been reported as early markers of renal damage3–4. Moreover, the production of guanidinoacetic acid (GAA) has been reported to be decreased in renal disease5.
KeywordsAngiotensin Converting Enzyme Urinary Excretion Essential Hypertension Plasma Renin Activity Hypertensive Group
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