Abstract
Water is an essential component as well as the most abundant molecule in all living systems. In magnetic resonance imaging (MRI) water is fundamental to image formation. Furthermore, the physical-chemical properties of cellular and extracellular water provide major contributions to the inherent contrast found in each image. The physical properties of water as a solvent are subject to change when macromolecular structure and/or motion is altered. Thus, precise knowledge of water-macromolecular interactions is required for our understanding of information content in an image obtained by magnetic resonance techniques.
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References
W. Drost-Hanson and J. S. Clegg (editors), “Cell-Associated Water”, Academic Press, Inc. New York (1979).
F. Franks (editor), “Biophysics of Water”, John Wiley and Sons, Inc. New York (1982).
G. N. Ling, “In Search of a Physical Basis of Life”, Plenum Press, New York (1984).
J. S. Clegg, S. Szwarnowski, V. E. R. McClean, R. J. Sheppard, and E. H. Grant, Interrelationships between Water and Cell Metabolism in Artemia cysts. X. Microwave Dielectric Studies, Biochem. Biophvs. Aeta. 721: 458 (1982).
P. A. Bottomly, T. H. Foster, R. E. Argersinger, and L. M. Pfeifer, A Review of Normal Tissue Hydrogen NMR Relaxation Times and Relaxation Mechanisms from 1-100 MHz: Dependence on Tissue Type, NMR Frequency, Temperature, Species, Excision, and Age, Med. Phvs. 11: 425 (1984).
P. A. Bottomly, T. H. Foster, R. E. Argersinger, and L. M. Pfeifer, A Review oflH Nuclear Magnetic Resonance Relaxation in Pathology: Are T1 and T2 Diagnostic?, Med. Phvs. 14: 1 (1987).
E. C.Trantham, H. E. Rorschach, J. S. Clegg, C. F. Hazlewood, R. M. Nicklow, and N. Wakabayashi, Diffusive Properties of Water in Artemia as Determined from Quasi-Elastic Neutron Scattering Spectra, Biophvs. J. 45: 927 (1984).
H. E. Rorschach, D. W. Bearden, C. F. Hazlewood, D. B. Heidorn, and R. M. Nicklow, Quasi-Elastic Scattering Studies of Water Diffusion, Scanning Microscopy 1: 2043 (1987).
D. D. Stark and W. G. Bradley, “Magnetic Resonance Imaging”, The C.W. Mosley Co. St. Louis, (1988).
N. Bloembergen, E. M. Purcell, and R. V. Pound, Relaxation Effects in Nuclear Magnetic Resonance Absorption, Phvs. Rev. 73: 679 (1948).
G. D. Fullerton, V. A. Ord, and I. L. Cameron, An Evaluation of the Hydration of Lysozyme by an NMR Titration Method, Biochem. Biophvs. Acta. 869: 230 (1986).
G. D. Fullerton, in.: “Magnetic Resonance Imaging”, D. D. Stark and W. G. Bradley, editors. The C.W. Mosley Co. St. Louis., 36 (1988).
S. E. Koenig, in: “Water in Polymers”, S.P. Rowland, editor. ACS Symp. Series No. 127: 157 (1980).
J. S. Clegg, Interrelationships between Water and Cell Metabolism in Artemia cysts. XI. Density Measurements, Cell Biophysics 6: 154 (1984).
J. S. Clegg, Properties and Metabolism of the Aqueous Cytoplasm and its Boundaries, Am. J. Physiol. 246:R–136 (1984).
J. S. Clegg, Interrelationships between Water and Cell Metabolism in Artemia cysts. Hydration-Dehydration from Liquid and Vapour Phases, J. Exptl. Biol. 61: 291 (1982).
K. Hallenga and S. E. Koenig, Protein Rotational Relaxation as Studied by Solvent 1H and 2H Magnetic Relaxation, Biochemistry 15: 4255 (1976).
J. M. Escanye, D. Canet, and J. Robert, Frequency Dependence of Water Proton Longitudinal Nuclear Magnetic Relaxation Times in Mouse Muscle at 20°C, Biochem. Biophys. Acta. 721: 305 (1982).
H. E. Rorschach and C. F. Hazlewood, Protein Dynamics and the NMR Relaxation Time Ti of Water in Biological Systems, J. Mag. Res. 70: 79 (1986).
A. L. Lehninger, “Biochemistry”, second edition, Worth Publishers, Inc., 130 (1975).
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© 1988 Plenum Press, New York
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Egan, T.F., Rorschach, H.E., Hazlewood, C.F. (1988). Molecular Basis of Contrast in MRI. In: Cañedo, L.E., Todd, L.E., Packer, L., Jaz, J. (eds) Cell Function and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0813-3_36
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DOI: https://doi.org/10.1007/978-1-4613-0813-3_36
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