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Recovery of Function After Tissue Transplantation in the Nigrostriatal Dopamine System

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Cell Function and Disease

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Abstract

Numerous reports spanning more than 70 years have established that small fetal brain tissue grafts consistently survive and frequently develop connections with the host brain. The basic methods for these investigations were first presented in 1917 by Elizabeth Dunn. Dunn (1917) reported the survival of immature rat cortex that had been transplanted into the cortex of other animals and evidence of connections between the grafts and the host brain. Shortly thereafter, Murphy and Sturm (1923) described the “privileged” status of the brain, which permits small tissue grafts to survive without rejection. Subsequently, Medawar (1948) discovered that graft rejection was an immunological phenomenon and that the privileged status of the brain had an immunological basis. Numerous investigators have confirmed that the brain is at least in part immunologically privileged (Albrink and Greene, 1953; Rosenstein and Brightman, 1978). Others have reported that not only does immature brain tissue survive transplantation, but it frequently develops substantial fiber connections with the host brain (Bjorklund et al., 1976; Le Gros Clark, 1940; Lund and Harvey,1981).

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Author information

Authors and Affiliations

  1. Psychology Department and Neuroscience Program Ann Arbor, The University of Michigan, MI, USA

    Jill B. Becker

  2. NIMH Neurosciences Center, St. Elizabeths, 20032, Washington, D.C., USA

    Williaro J. Freed

Authors
  1. Jill B. Becker
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  2. Williaro J. Freed
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Editor information

Editors and Affiliations

  1. Department of Biochemistry School of Medicine, University of Nuevo Leon, Monterrey, Nuevo Leon, Mexico

    L. E. Cañedo

  2. Magnetic Resonance Unit, University Hospital, Monterrey, Nuevo Leon, Mexico

    L. E. Todd

  3. Lawrence Berkeley Laboratory, University of California, Berkeley, California, USA

    L. Packer

  4. International Biomedical Institute, Bari, Italy

    J. Jaz

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© 1988 Plenum Press, New York

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Becker, J.B., Freed, W.J. (1988). Recovery of Function After Tissue Transplantation in the Nigrostriatal Dopamine System. In: Cañedo, L.E., Todd, L.E., Packer, L., Jaz, J. (eds) Cell Function and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0813-3_20

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  • DOI: https://doi.org/10.1007/978-1-4613-0813-3_20

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  • Online ISBN: 978-1-4613-0813-3

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