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Cell Function and Disease pp 171–188Cite as

Molecular Basis Of Radioprotection By Aminothiols

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Abstract

It is now well established that aminothiols are radioprotector agents, and in some cases anticancer drugs1–6. Aminothiols which belong to the radioprotector family are able to reduce the radiation damage when administrated to animals or cellular cultures before irradiationwith ionizing radiation. These drugs are characterized by their dose reduction factor (DRF = ratio of lethal dose of irradiation for 50% of animals treated with radioprotector to lethal dose of irradiation for 50% of control animals). On another hand, it was shown that both in vivo and in vitro conditions, ionizing radiation (UV, X or γ rays) induce, by intermediate radicals or hydrated electrons, single breaks and double breaks of DNA backbone and base modifications7–10.

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Author information

Authors and Affiliations

  1. Biophysics Laboratory, Nice University, Parc Valrose, 06034, Nice Cedex, France

    Dan Vasilescu

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  1. Dan Vasilescu
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Editor information

Editors and Affiliations

  1. Department of Biochemistry School of Medicine, University of Nuevo Leon, Monterrey, Nuevo Leon, Mexico

    L. E. Cañedo

  2. Magnetic Resonance Unit, University Hospital, Monterrey, Nuevo Leon, Mexico

    L. E. Todd

  3. Lawrence Berkeley Laboratory, University of California, Berkeley, California, USA

    L. Packer

  4. International Biomedical Institute, Bari, Italy

    J. Jaz

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© 1988 Plenum Press, New York

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Vasilescu, D. (1988). Molecular Basis Of Radioprotection By Aminothiols. In: Cañedo, L.E., Todd, L.E., Packer, L., Jaz, J. (eds) Cell Function and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0813-3_15

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  • DOI: https://doi.org/10.1007/978-1-4613-0813-3_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8095-8

  • Online ISBN: 978-1-4613-0813-3

  • eBook Packages: Springer Book Archive

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