Protein Kinase C: Structure, Function And Modulation Of Its Catalytic Activity By Physiological And Pharmacological Agents

Mahoney, Charles W.; Azzi, Angelo

doi:10.1007/978-1-4613-0813-3_11

Charles W. Mahoney⁵ &
Angelo Azzi⁵

185 Accesses

Abstract

Extracellular agonist-cell surface receptor cell activation pathways can be mediated through the second messengers diacylglycerol and inositol-triphosphate which in turn can activate PKC kinase activity directly in the former case and indirectly in the latter by release of internally stored calcium. The initial steps of physiological cell activation processes are often of a transient nature and hence there have to be mechanisms for turning off the activation process. Several mechanisms of deactivation have been elucidated such as the metabolism of DAG to either phosphatidic acid (re-generation of phosphatidylinositol path) or further catabolism to monoacyl-glycerol and glycerol thereby generating fatty acids such as arachidonic acid, which can be further metabolized to a series of potent biological effectors, the prostaglandins. Inositol-1,4,5-triphosphate (IP₃) is also normally a transient message being further phosphorylated to IP₄ and IP₅ and IP₆ or being dephosphorylated to IP₂, IP₁, and inositol (regeneration of phosphatidylinositol path) (for reviews see Nishizuka, 1984, 1986; Berridge, 1987).

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Institut für Biochemie und Molekularbiologie, Universität Bern, 3012, Bern, Switzerland
Charles W. Mahoney & Angelo Azzi

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Charles W. Mahoney
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Department of Biochemistry School of Medicine, University of Nuevo Leon, Monterrey, Nuevo Leon, Mexico
L. E. Cañedo
Magnetic Resonance Unit, University Hospital, Monterrey, Nuevo Leon, Mexico
L. E. Todd
Lawrence Berkeley Laboratory, University of California, Berkeley, California, USA
L. Packer
International Biomedical Institute, Bari, Italy
J. Jaz

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Mahoney, C.W., Azzi, A. (1988). Protein Kinase C: Structure, Function And Modulation Of Its Catalytic Activity By Physiological And Pharmacological Agents. In: Cañedo, L.E., Todd, L.E., Packer, L., Jaz, J. (eds) Cell Function and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0813-3_11

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DOI: https://doi.org/10.1007/978-1-4613-0813-3_11
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