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The Influenza Viruses pp 175–218Cite as

Neuraminidase

Enzyme and Antigen

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Part of the book series: The Viruses ((VIRS))

Abstract

The discovery of enzymatic activity on the surface of influenza virus is attributable to Hirst (1942), who observed that it was not possible to reagglutinate red blood cells (RBC) after they had once been agglutinated by the virus. The modification to the cells resulting from the first contact with virus is now known to be the specific removal of sialic acid (N-acetylneuraminic acid) from glycoconjugates on the RBC surface by the viral neuraminidase. The enzyme action of the neuraminidase destroys the receptors for the viral hemagglutinin. Bacterial neuraminidases, as found for example in culture filtrates of Vibrio cholerae also render RBC nonagglutinable by influenza virus (Burnet and Stone, 1947).

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  1. Division of Biotechnology, CSIRO, Parkville, 3052, Australia

    P. M. Colman

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  1. Graduate Program in Molecular Biology, Memorial Sloan-Kettering Cancer Center, 10021, New York, New York, USA

    Robert M. Krug

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Colman, P.M. (1989). Neuraminidase. In: Krug, R.M. (eds) The Influenza Viruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0811-9_4

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