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Lymphocytic interstitial pneumonitis in adult HIV infection

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Acquired Immunodeficiency Syndrome

Abstract

Pulmonary disease associated with acquired immunodeficiency syndrome (AIDS) is common and may be secondary to infectious and noninfectious processes.1 One of the noninfectious processes is lymphocytic interstitial pneumonitis (LIP). LIP is an uncommon disorder that was first described by Carrington and Liebow2 in 1966, and is characterized by a diffuse peribronchial and interstitial infiltration of the lung by lymphocytes and plasma cells.3 LIP has been recognized as a common pulmonary complication in cases of pediatric AIDS and appears to be present in as many as 75% of these cases.4 The present Centers for Disease Control (CDC) classification includes LIP as a diagnostic criterion for pediatric AIDS.5

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References

  1. Stover DE, White DA, Romano PA, et al: Spectrum of pulmonary diseases associated with the acquired immune deficiency syndrome. Am J Med 1985; 78:429–437.

    Article  PubMed  CAS  Google Scholar 

  2. Carrington CB, Liebow AA: Lymphocytic interstitial pneumonia (abstract). Am J Path 1966; 48:36a.

    Google Scholar 

  3. Liebow AA, Carrington CB: The interstitial pneumonias, in Simon M, Potchen EJ, Le May M (eds): Frontiers of Pulmonary Radiology: Pathophysiologic, Roentgenographies and Radioisotopic Considerations. New York, Grune & Stratton, 1969, pp 102–141.

    Google Scholar 

  4. Scott GB, Buck BE, Leterman JG, et al: Acquired immunodeficiency syndrome in infants. N Engl J Med 1984; 310:76–81.

    Article  PubMed  CAS  Google Scholar 

  5. Revision of the case definition of AIDS for national reporting—United States. MMWR 1985; 34:373–375.

    Google Scholar 

  6. Couderc LJ, Herve P, Solal-Celigny P, et al: Pneumonie lymphoide interstitielle et polyadenopathies chez des sujets infectés par le virus LAV/HTLV III. Presse Med 1986; 15:1127–1130.

    PubMed  CAS  Google Scholar 

  7. Morris JC, Rosen MJ, Marchevsky A, et al: Lymphocytic interstitial pneumonia in patients at risk for the acquired immune deficiency syndrome. Chest 1987; 91:63–67.

    Article  PubMed  CAS  Google Scholar 

  8. Grieco MH, Chinoy-Acharya P: Lymphocytic interstitial pneumonia associated with the acquired immune deficiency syndrome. Am Rev Respir Dis 1986; 131:952–955.

    Google Scholar 

  9. Ziza JM, Brun Vezinet F, Venet A, et al: Pneumopathie lymphocytaire interstielle au cours d’un ARC. Preśence du virus LAV dans le liquide de lavage broncho-alveolaire. Presse Med 1986; 15: 1267–1269.

    PubMed  CAS  Google Scholar 

  10. Saldana MJ, Mones J, Buck BE: Lymphoid interstitial pneumonia in Haitian residents of Florida. Chest 1983; 84:347.

    Google Scholar 

  11. Solal-Celigny P, Couderc LJ, Herman D, et al: Lymphoid interstitial pneumonitis in acquired immunodeficiency syndrome-related complex. Am Rev Respir Dis 1985; 131:956–960.

    PubMed  CAS  Google Scholar 

  12. Kradin RL, Mark EJ: Benign lymphoid disorders of the lung, with a theory regarding their development. Hum Path 1983; 14:857–867.

    Article  PubMed  CAS  Google Scholar 

  13. Sifai B, Koziner B: Malignant neoplasm in AIDS, in De Vita VT Jr, Hellman S, Rosenberg SA (eds): AIDS—Etiology, Diagnosis, Treatment, and Prevention. New York, JB Lippincott Co, 1985, pp 213–222.

    Google Scholar 

  14. Sallahuddin SZ, Ablashi DV, Markham PD, et al: Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 1986; 234: 596–601.

    Article  Google Scholar 

  15. Turner RR, Colby TV, Doggett RS: Well differentiated lymphocytic lymphoma. A study of 47 patients with primary manifestation in the lung. Cancer 1984; 54:2088–2096.

    Article  PubMed  CAS  Google Scholar 

  16. Joshi VV, Oleske JM, Minnefor AB, et al: Pathology of suspected acquired immune deficiency syndrome in children: A study of eight cases. Pediatr Pathol 1984; 2:71–87.

    Article  PubMed  CAS  Google Scholar 

  17. Biberfeld P, Porwit-Ksiazek A, Böttinger B: Immunohistopathology of lymph nodes in HTLV-III infected homosexuals with persistent adenopathy or AIDS. Cancer Res 1985; 45:4665S–4670S.

    PubMed  CAS  Google Scholar 

  18. Suffredini AF, Ognibene FP, Lack EE, et al: Nonspecific interstitial pneumonitis: A common cause of pulmonary disease in the acquired immune-deficiency syndrome. Ann Intern Med 1987; 107: 7–13.

    PubMed  CAS  Google Scholar 

  19. Strimlan CV, Rosenow EC 3d, Weiland LH, et al: Lymphocytic interstitial pneumonitis. Review of 13 cases. Ann Intern Med 1978; 86:616–621.

    Google Scholar 

  20. Silverman B, Charytan B, BenZion K, et al: Chronic interstitial pneumonitis in pediatric AIDS and AIDS related complex (prodrome). Pediatr Res 1984; 18:265.

    Google Scholar 

  21. Ziegler JL, Abram DI: The AIDS related complex, in DeVita VT Jr, Hellman S, Rosenberg SA (eds): AIDS: Etiology, Diagnosis, Treatment, and Prevention. New York, JB Lippincott, 1985, pp 223–234.

    Google Scholar 

  22. Bowen DL, Lane HC, Fauci AS: Immunologic features of AIDS, in DeVita VT Jr, Hellman S, Rosenberg SA (eds): AIDS: Etiology, Diagnosis, Treatment, and Prevention. New York, JB Lippincott, 1985, pp 111–160.

    Google Scholar 

  23. Fackler JC, Nagel JE, Adler WH, et al: Epstein-Barr virus infection in a child with acquired immunodeficiency syndrome. Am J Dis Child 1985; 139:1000–1004.

    PubMed  CAS  Google Scholar 

  24. Wallace JM, Barbers RG, Oishi JS, et al: Cellular and T-lymphocyte subpopulation profiles in bronchoalveolar lavage fluid from patients with acquired immunodeficiency syndrome and pneumonitis. Am Rev Respir Dis 1984; 130:786–790.

    PubMed  CAS  Google Scholar 

  25. Lin RY: Severe spirometric defects in systemic lupus erythematosus: A possible role for bronchoalveolar lavage and gallium scanning. Clin Rheum 1987; 6:276–281.

    Article  CAS  Google Scholar 

  26. Crystal RG, Bitterman PB, Rennard SI, et al: Interstitial lung disease of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract. N Engl J Med 1984; 310:154–166, 235–244.

    Article  PubMed  CAS  Google Scholar 

  27. Julsrud PR, Brown LR, Li CY, et al: Pulmonary processes of mature-appearing lymphocytes: Pseudolymphoma, well-differentiated lymphocytic lymphoma, and lymphocytic interstitial pneumonitis. Radiology 1978; 127:289–296.

    PubMed  CAS  Google Scholar 

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© 1989 Medical Society of the State of New York

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Lin, R.Y., Gruber, P.J., Saunders, R., Perla, E.N. (1989). Lymphocytic interstitial pneumonitis in adult HIV infection. In: Imperato, P.J. (eds) Acquired Immunodeficiency Syndrome. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0807-2_38

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  • DOI: https://doi.org/10.1007/978-1-4613-0807-2_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8092-7

  • Online ISBN: 978-1-4613-0807-2

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