Oral candidiasis and AIDS

  • Jeffrey S. Gelwan
  • Burton M. Gold
  • Henry J. Shih
  • Crescens Pellecchia

Abstract

Candidal infections of the gastrointestinal tract are common in patients with acquired immunodeficiency syndrome (AIDS). Oral candidiasis, though not diagnostic of the syndrome, has been shown to carry a poor prognosis in patients in the prodromal stage, called AIDS-related complex (ARC).1–3 In a prospective study of high-risk patients with unexplained oral candidiasis, Klein et al1 found that 59% of these patients acquired a major opportunistic infection or secondary cancer at a median interval of three months. The authors concluded that in high-risk patients, oral candidiasis may represent an intermediate stage in the spectrum of disease that progresses from ARC to AIDS.

Keywords

Depression Lymphoma Sedimentation Anemia Diarrhea 

References

  1. 1.
    Klein RS, Harris CA, Small CS, et al: Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med 1984; 311:354–358.PubMedCrossRefGoogle Scholar
  2. 2.
    Romanowski B, Weber J: Oral candidiasis and the acquired immunodeficiency syndrome [letter]. Ann Intern Med 1984; 101:400–401.PubMedGoogle Scholar
  3. 3.
    Chandrasekar PH, Molinari JA: Oral candidiasis: Forerunner of acquired immunodeficiency syndrome (AIDS)? Oral Surg Oral Med Oral Pathol 1985; 60:532–534.PubMedCrossRefGoogle Scholar
  4. 4.
    Tavitian A, Raufman J-P, Rosenthal LE, et al: Oral candidiasis indicates esophageal candidiasis in patients with AIDS and AIDS-related complex, in Abstracts submitted for 50th annual scientific meeting, American College of Gastroenterology. Am J Gastroenterology 1985; 80:867.Google Scholar
  5. 5.
    Tavitian A, Raufman J-P, Rosenthal LE: Oral candidiasis as a marker for esophageal candidiasis in the acquired immunodeficiency syndrome. Ann Intern Med 1986; 104:54–55.PubMedGoogle Scholar
  6. 6.
    Gelb A, Miller S: AIDS and gastroenterology. Am J Gastroenterology 1986; 81:619–622.Google Scholar
  7. 7.
    Kodsi BE, Wickremesinghe C, Kozinn PJ, et al: Candida esophagitis. A progressive study of 27 cases. Gastroenterology 1976; 71:715–719.PubMedGoogle Scholar
  8. 8.
    Epstein JB, Truelove EL, Izutzu KT: Oral candidiasis: Pathogenesis and host defense. Rev Infect Dis 1984; 6:96–106.PubMedCrossRefGoogle Scholar

Copyright information

© Medical Society of the State of New York 1989

Authors and Affiliations

  • Jeffrey S. Gelwan
    • 1
  • Burton M. Gold
    • 1
  • Henry J. Shih
    • 1
  • Crescens Pellecchia
    • 1
  1. 1.Division of Gastroenterology and the Departments of Radiology and PathologyNassau County Medical CenterEast MeadowUSA

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