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Celiac Disease

Pathogenesis and Clinical Features
  • Martin F. Kagnoff
Part of the Topics in Gastroenterology book series (TGEN)

Abstract

Celiac disease (gluten-sensitive enteropathy, celiac sprue, or nontropical sprue) is characterized by damage to the small intestine mucosa and the malabsorption of most nutrients. Symptoms most commonly appear during the first 3 years of life after the introduction of cereals into the diet, with a second peak incidence occurring during the third decade.1 Clinical manifestations predominantly reflect the consequences of malabsorption. Although celiac disease was noted in earlier centuries,2,3 a striking decrease in the incidence of celiac disease was observed in Holland during the wheat-deprived years of World War II; this suggested an association between celiac disease and the ingestion of wheat-containing products.4,5

Keywords

Celiac Disease Coeliac Disease Celiac Disease Patient Dermatitis Herpetiformis Celiac Sprue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Martin F. Kagnoff
    • 1
  1. 1.Laboratory of Mucosal Immunology, Department of MedicineUniversity of California-San DiegoLa JollaUSA

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