Abstract
Many theories have been proposed to explain the pathogenesis of multiple sclerosis. From epidemiologic studies the occurrence of disease can be associated with genetic and environmental factors (reviewed by 1). Some of the environmental factors include infectious agents (37). Thus far, many agents including a whole host of viruses have been implicated, however, none have been shown definitively to be the causative agent (2–4, 12, 19, 21, 25, 29, 31, 41, 44). In addition, immunologic factors may play an important role in the pathogenesis (30). Along this premise some investigators have been using immunosuppressive regimes to modify the course of the disease (reviewed by 10). These studies have suggested modest improvement in some of the patients. Several models have been put forth to delineate the role of virus and immune responses in reproducing the observed pathologic features of multiple sclerosis.
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Keywords
- Multiple Sclerosis
- Myelin Basic Protein
- Measle Virus
- Demyelinating Disease
- Experimental Allergic Encephalomyelitis
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© 1989 Plenum Press, New York
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Fujinami, R.S. (1989). Molecular Determinants in Autoimmunity. In: Kim, S.U. (eds) Myelination and Demyelination. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0777-8_9
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DOI: https://doi.org/10.1007/978-1-4613-0777-8_9
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