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The Primary Structure of Myelin Associated Glycoprotein Suggests a Role in Myelination

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Myelination and Demyelination

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Abstract

The molecular events that control the interaction of Schwann cells or oligodendrocytes with neurons and finally lead to myelination are at present not understood. A detailed knowledge of the process of myelination is needed in order to reach the long-term goal of improving the prognosis of human demyelinating disorders, possibly by promoting efficient remyelination. A body of evidence has accumulated indicating that major morphological changes during neural development are caused by the interaction of cells through adhesion molecules expressed on their surface. It appears likely that specific cell adhesion is also crucial to the process of myelination. In this review we summarize the structural characteristics of myelin associated glycoprotein (MAG) and discuss how it may be involved in cell interactions leading to myelination.

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Authors and Affiliations

  1. Division of Molecular Immunology and Neurobiology, Mount Sinai Hospital Research Institute, Canada

    Monique Arquint, Michael B. Tropak, Paul W. Johnson & John C. Roder

  2. Department of Medical Genetics, Univ. of Toronto, Canada

    Michael B. Tropak, Robert J. Dunn & John C. Roder

  3. Department of Immunology, University of Toronto, Toronto, Canada

    John C. Roder

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  1. Monique Arquint
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  2. Michael B. Tropak
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  3. Paul W. Johnson
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  4. Robert J. Dunn
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  5. John C. Roder
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  1. University Hospital, University of British Columbia, Vancouver, British Columbia, Canada

    Seung U. Kim

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© 1989 Plenum Press, New York

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Arquint, M., Tropak, M.B., Johnson, P.W., Dunn, R.J., Roder, J.C. (1989). The Primary Structure of Myelin Associated Glycoprotein Suggests a Role in Myelination. In: Kim, S.U. (eds) Myelination and Demyelination. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0777-8_5

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  • DOI: https://doi.org/10.1007/978-1-4613-0777-8_5

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