Yeast Killer Toxin Monoclonal Antibodies

  • L. Polonelli
  • M. Castagnola
  • G. Morace

Abstract

Killer yeasts and toxins have been extensively studied in our Institute for strain differentiation of pathogenic yeasts within the species and as epidemiological markers for the control and prevention of yeast nosocomial infections. Subsequently, we observed that the killer phenomenon, which was previously considered to be restricted to yeasts, also occurs among unrelated microorganisms. The potential therapeutic effect of a yeast killer toxin on experimental mycotic infections in laboratory animals prompted us to try purification and characterization of the yeast killer toxin apparently produced by Hansenula anomala UCSC 25F. Monoclonal antibodies were raised against the toxin and used in affinity chromatography.

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • L. Polonelli
    • 1
  • M. Castagnola
    • 2
  • G. Morace
    • 1
  1. 1.Instituto di MicrobiologiaUniversità Cattolica del Sacro CuoreRomaItaly
  2. 2.Instituto di ChimicaUniversità Cattolica del Sacro CuoreRomaItaly

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