Differential Expression Of Secretory Proteinase by CandidaAlbicans and C. Parapsilosis Invading Human Mucosa
Opportunistic yeasts of the oral microbial flora can cause infections like thrush or denture stomatitis. The most relevant fungal species in such loci is Candida albicans, followed by C. tropicalis and to a lesser extent by C. parapsilosis. Among the various yeast-like fungi found in clinical specimens, these three species are distinguished by secretion of acid proteinase in vitro (R. Ruchel et. al., 1986, Infect Immun., 53:411). The in vitro activity does not reflect the large difference of virulence among the three proteolytic Candida species. Previously we have shown that avirulent C. parapsilosis do not express proteinase during infection of cultured phagocytes (R. Rüchel et al., 1986, Infect. Immun., 53:411). In the present investigation we tried to answer the question whether such differential expression of proteinase might account for the different virulence of the three fungal species in the oral cavity.