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A Neural Thyroid Hormone Receptor Gene

  • Chapter
Iodine and the Brain

Abstract

One of the prominent questions surrounding tissue-specific gene activation is how a single hormone type such as thyroxine can have such diverse physiological effects. Generally, two mechanisms contribute to the particular variety of proteins synthesized either during development or in response to required physiological changes. On the one hand, specific DNA tertiary structure induced by associated nuclear proteins probably presets the transcriptional activity of target cell gene networks (1). An additional constraint is likely provided by hormones or growth factors mediating changing gene expression patterns (2). Each cell produces distinct receptor proteins which determine the effective response to hormonal stimulation. In this manner, both the ontogenetic history of a particular cell type and the hormone receptor field, or its distribution in specific cell types, limit the scope of induced proteins during animal development and homeostasis.

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Author information

Authors and Affiliations

  1. Laboratory of Cell Biology, USA

    Cary Weinberger & David J. Bradley

  2. Howard Hughes Medical Institute, USA

    David J. Bradley & Ronald M. Evans

  3. Unit on Functional Neuroanatomy, NIMH, Bethesda, MD 20892, USA

    Linda S. Brady

  4. Gene Expression Laboratory, The Salk Institute for Biological Studies, San Diego, CA, 92138, USA

    Catherine C. Thompson & Ronald M. Evans

Authors
  1. Cary Weinberger
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  2. David J. Bradley
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  3. Linda S. Brady
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  4. Catherine C. Thompson
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  5. Ronald M. Evans
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Editor information

Editors and Affiliations

  1. Duke University Medical Center, Durham, North Carolina, USA

    G. Robert DeLong

  2. National Institutes of Health, Bethesda, Maryland, USA

    Jacob Robbins  & Peter G. Condliffe  & 

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© 1989 Plenum Press, New York

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Weinberger, C., Bradley, D.J., Brady, L.S., Thompson, C.C., Evans, R.M. (1989). A Neural Thyroid Hormone Receptor Gene. In: DeLong, G.R., Robbins, J., Condliffe, P.G. (eds) Iodine and the Brain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0765-5_4

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  • DOI: https://doi.org/10.1007/978-1-4613-0765-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8071-2

  • Online ISBN: 978-1-4613-0765-5

  • eBook Packages: Springer Book Archive

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