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Early Correction of Iodine Deficiency and Late Effects on Psychomotor Capabilities and Migration

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Abstract

This is a study of the long-term effects of administration of iodized oil in two Andean rural communities: Tocachi and La Esperanza. This program of prophylaxis was started in March 1966 (1). At that time these two neighboring villages were similar in terms of isolation, ethnic composition, degree of iodine deficiency, and socioeconomic conditions (protein-calorie malnutrition, annual income per capita, cultural deprivation, etc.) They presented similar prevalences of iodine deficiency disorders. In March 1966 the total population of Tocachi was treated; La Esperanza was used as a control. Women of childbearing age and children born in Tocachi were re-injected or injected in 1970, 1974, 1978, 1982 and 1986. All children born after the program was started were examined at the time of birth and at key stages of development: both physical growth and neuromotor maturation were observed until they were 5 years old (2–4). This part of the program was finished in 1973. In that year the intellectual capacity of those 3 to 7 years of age was studied (5, 6). In 1980 a subprogram of screening of neonatal hypothyroidism was started (7). In 1981 in those children born from 1966 to 1973 (8 to 15 years old) the effects of iodized oil on neural and psychological development, as measured by a battery of tests and by school performance, were studied (8).

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References

  1. Fierro-Benítez, R., I. Ramírez, E. Estrella, C. Jaramillo, C. Díaz, and U. Urresta, Iodized oil in the prevention of endemic goiter and associated defects in the Andean region of Ecuador. I. Program design, effects on goiter prevalence, thyroid function, and iodine excretion, in “Endemic Goiter,” J. B. Stanbury, Ed., PAHO Scientific Publication 193, Washington, D.C. (1969), pp. 306–340

    Google Scholar 

  2. Ramírez, I., R. Fierro-Benítez, E. Estrella, C. Jaramillo, C. Díaz, and J. Urresta, Iodized oil in the prevention of endemic goiter and associated defects in the Andean region of Ecuador. II. Effects on neuro-motor development and somatic growth in children before two years, in: “Endemic Goiter,” J. B. Stanbury, Ed., PAHO Scientific Publication 193, Washington, D.C. (1969), pp. 341–359

    Google Scholar 

  3. Fierro-Benítez, R., I. Ramírez, E. Estrella, A. Querido, and J. B. Stanbury, The effect of goiter prophylaxis with iodized oil on the prevention of endemic cretinism, in: “Further Advances in Thyroid Research,” K. Fellinger and R. Hofe, Eds., Verlag der Wiener Medizinischen Akadamie, Wien, (1979), Vol. 1, pp. 61–77

    Google Scholar 

  4. Ramírez, I., R. Fierro-Benítez, E. Estrella, A. Gomez, C. Jaramillo, C. Her- mida, and F. Moncayo, The results of prophylaxis of edemic cretinism with iodized oil inrular Andean Ecuador, in: “Human Development and the Thyroid Galnd RElation to Edemic Cretinism,” J. B. Stanbury and R.L. Koc, Eds., Plenum Press, New York (1972), pp. 223–237

    Google Scholar 

  5. Fíerro-Benítez, R., I. Ramirez, and J. Reinhart. The role of iodine on intellectual deficiency in areas of chronic iodine deficiency and protein-calorie malnutrition. Tenth International Congress of Nutrition, Kyoto (1975), p. 37

    Google Scholar 

  6. Fierro-Benítez, R., I. Ramirez, E. Estrella, and J. B. Stanbury, The role of iodine in intellectual development in an area of endemic goiter, in: “Endemic Goiter and Cretinism: Continuing Threats to World Health,” J. T. Dunn and G. A. Medeiros-Neto, Eds., PAHO Scientific Publication 292, Washington, D.C. (1974), pp. 135–142

    Google Scholar 

  7. Fierro-Benítez, R., A. Jijon, J. C. Zevallos, F. Fierro-Renoy, S. Guijarro, F. Chiriboga, F. Gandara, M. Martinod, V. M. Pacheco, M. Roman and J. B. Stanbury, A pilot program for screening congenital hypothyroidism in an undeveloped country, in: “Iodine Deficiency Disorders and Congenital Hypothyroidism,” G. Medeiros-Neto, R. M. B. Maciel, and A. Halpem, Eds., Ache, Sao Paulo (1986), pp. 261–266

    Google Scholar 

  8. Fierro-Benítez, R., R. Cazar, J. B. Stanbury, P. Rodriguez, F. Garcés, F. Fierro-Renoy, and E. Estrella, Long-term effects of correction of iodine deficiency on psychomotor and intellectual development, in: “Towards the Eradication of Endemic Goiter, Cretinism, and Iodine Deficiency,” J. T. Dunn, E. A. Pretell, C. H. Daza, and F. E. Vitery, Eds., PAHO Scientific Publication 502, Washington, D.C. (1986), pp. 182–200

    Google Scholar 

  9. Gesell, A, “Children from One to Four Years,” Paidos. Ed., Buenos Aires (1966)

    Google Scholar 

  10. Gesell, A., and C. S. Amatruda, “Diagnostico del Desarrollo Normal y Anormal del nino,” Paidos, Ed., Buenos Aires (1966)

    Google Scholar 

  11. Stanbury, J. B., R. Fierro-Benitez, E. Estrella, P. S. Milutinovic, M. U. Tellez, and S. Refetoff, Endemic goiter with hypothyroidism in three generations, Journal of Clinical Endocrinological Metabolism, 29:1596–1600 (1969)

    Article  CAS  Google Scholar 

  12. Terman, L. M., and M. A. Merrill, “Stanford-Binet Intelligence Scale,” Houghton-Mifflin Company, Boston (1962)

    Google Scholar 

  13. Pichot, P., “Los Tests Mentales,” Paidos, Ed., Buenos Aires (1963)

    Google Scholar 

  14. Navas, M., “Escala de Aptitud Intelectual de Binet-Terman,” Quito (1971)

    Google Scholar 

  15. Navas, M., “Prueba de Aptitud Intelectual de Wechsler,” Quito (1969)

    Google Scholar 

  16. Goodenough, F., “Test de Inteligencia Infantil por Medio del Dibujo de la Figura Humana,” Paidos, Ed., Buenos Aires (1957)

    Google Scholar 

  17. Goddard, S., “Test de Reintegracion Motriz,” Paidos, Ed., Buenos Aires (1975)

    Google Scholar 

  18. Bender, L., “Test Gestaltico Visomotor: Usos y Aplicaciones Clinicas,” Paidos, Ed., Buenos Aires (1977)

    Google Scholar 

  19. Raven, J. C., “Coloured Progressive Matrices,” London (1962)

    Google Scholar 

  20. Bernstein, J., “Tests de Matrices Progresivas de Raven,” Paidos, Ed., Buenos Aires (1976)

    Google Scholar 

  21. Pérez, C., N. S. Scrimshaw, and J. A. Munõz, Technic of endemic goiter surveys, in: “Endemic Goiter,” WHO Monograph Series 44, Geneve (1960), pp. 369–378.

    Google Scholar 

  22. Querido, A., F. Delange, J. T. Dunn, R. Fierro-Benítez, H. K. Ibbertson, D. A. Koutras, and H. Perinetti, Definition of endemic goiter and cretinism, classification of goiter size and severity of endemias, and survey technics, in: “Endemic Goiter and Cretinism: Continuing Threats to World Health,” J. T. Dunn and G. A. Medeiros-Neto, Eds., PAHO Scientific Publication 292, Washington, D.C. (1974), pp. 267–272.

    Google Scholar 

  23. Consejo Nacional de Desarrollo. Tablas de Indicadores Socio economics, Quito, CONADE (1985)

    Google Scholar 

  24. Molina, J., “Las Migraciones Internas en el Ecuador,” Universitaria, Ed., Quito (1965)

    Google Scholar 

  25. Estevez de, M., “inmigracion a Quito,” Revista Cultura 20:56–72 (1984)

    Google Scholar 

  26. Centro de Estudios de Población y Paternidad Responsable, “Inmigracion a Quito y Guayaquil,” CEPAR, Quito (1985)

    Google Scholar 

  27. Debuyst, F., “La Población en America Latina, Demografia y Evolucion de Empleos,” Gabiota, Ed., Buenos Aires (1973), pp. 250–283

    Google Scholar 

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© 1989 Plenum Press, New York

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Fierro-Benítez, R. et al. (1989). Early Correction of Iodine Deficiency and Late Effects on Psychomotor Capabilities and Migration. In: DeLong, G.R., Robbins, J., Condliffe, P.G. (eds) Iodine and the Brain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0765-5_26

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  • DOI: https://doi.org/10.1007/978-1-4613-0765-5_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8071-2

  • Online ISBN: 978-1-4613-0765-5

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