The Fetus and Iodine Deficiency: Marmoset and Sheep Models of Iodine Deficiency
Iodine Deficiency Disorders (IDD) are a major international public health problem (1). The effects of iodine deficiency occur at all ages, but are particularly important during the period of fetal development. The available epidemiological evidence has been complemented by experimental studies of fetal development in animal models. These have focussed particularly on fetal brain development because of its obvious importance. Definite effects have been observed in a variety of animal models — the rat, the marmoset and the sheep. In addition studies of the mechanisms involved have been carried out which have revealed the importance of maternal thyroid function for fetal brain development.
KeywordsIodine Deficiency Iodine Deficiency Disorder Fetal Sheep Iodine Deficiency Disorder Spastic Diplegia
Unable to display preview. Download preview PDF.
- 2.Dobbing, J. The later development of the brain and its vulnerability, in; “Scientific Foundations of Paediatrics”, J.A. Davis and J. Dobbing, eds. Heinemann Medical, London (1974) pp. 565–577Google Scholar
- 6.Fisher, D.A., Dussault, J.H., Erenberg,A. and Lam, R.W. Thyroxine and triiodothyronine metabolism in maternal and fetal sheep. Pediatric Research12: 894 – 899 (1972)Google Scholar
- 13.Potter, B.J., Mcintosh, G.H. and Hetzel, B.S. The effect of iodine deficiency on fetal brain development in sheep, in: “Fetal Brain Disorders - Recent Approaches to the Problem of Mental Deficiency” B.S. Hetzel and R.M. Smith Eds. Elsevier, Amsterdam (1981) pp.119–148Google Scholar
- 14.Erenberg, A. and Fisher, D.A. Thyroid hormone metabolism in the fetus, in: “Fetal and Neonatal Physiology” R.S. Comline, K. W. Cross, G.S. Dawes and P.W. Nathanielsz eds. Cambridge University Press, Cambridge (1973) pp. 508–526Google Scholar
- 15.Thorburn, G.D. and Hopkins, P.S. Thyroid function in the fetal lamb, in: “Fetal and Neonatal Physiology”,R.S. Comline, K.W. Cross, G.S. Dawes and P.W. Nathanielsz eds. Cambridge University Press, Cambridge (1973) pp. 488–507Google Scholar
- 16.Fisher, D.A., Dussault, J.H., Sack, J. and Chopra, I.J. Ontogenesis of hypothalamic pituitary thyroid function and metabolism in man, sheep and rat. Rec. Prog. Horm. Res. 33: 593–116 (1977)Google Scholar
- 18.Hamburgh, M. The role of thyroid and growth hormone in neurogenesis, in: “Current Topics in Developmental Biology”, J. Moscona and J. Monroy eds. Academic Press, New York (1969) 4: 109Google Scholar
- 23.DeLong, R. Neurological involvement in iodine deficiency disorders, in: “The Prevention and Control of Iodine Deficiency Disorders”, B.S. Hetzel, J.T. Dunn and B.S. Stanbury eds. Elsevier, Amsterdam (1987) pp. 49–63Google Scholar
- 24.Pharoah, P.O.D. Epidemiological studies of endemic cretinism in the Jimi River Valley in New Guinea, in: “Endemic cretinism”, B.S. Hetzel and P.O.D. Pharoah eds, Papua New Guinea Institute of Human Biology Monograph Series (1971) 2: 109–116Google Scholar