The Fetus and Iodine Deficiency: Marmoset and Sheep Models of Iodine Deficiency

  • Basil S. Hetzel
  • Mark L. Mano
  • J. Chevadev

Abstract

Iodine Deficiency Disorders (IDD) are a major international public health problem (1). The effects of iodine deficiency occur at all ages, but are particularly important during the period of fetal development. The available epidemiological evidence has been complemented by experimental studies of fetal development in animal models. These have focussed particularly on fetal brain development because of its obvious importance. Definite effects have been observed in a variety of animal models — the rat, the marmoset and the sheep. In addition studies of the mechanisms involved have been carried out which have revealed the importance of maternal thyroid function for fetal brain development.

Keywords

Cholesterol Migration Maize Cage Iodine 

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Basil S. Hetzel
    • 1
  • Mark L. Mano
    • 1
  • J. Chevadev
    • 2
    • 3
  1. 1.Division of Human NutritionCSIROAdelaideAustralia
  2. 2.Dept. PhysiologyMonash UniversityClayton, Vic.Australia
  3. 3.Dept. AnatomyMahidol UniversityBangkokThailand

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