The Fetus and Iodine Deficiency: Marmoset and Sheep Models of Iodine Deficiency

  • Basil S. Hetzel
  • Mark L. Mano
  • J. Chevadev


Iodine Deficiency Disorders (IDD) are a major international public health problem (1). The effects of iodine deficiency occur at all ages, but are particularly important during the period of fetal development. The available epidemiological evidence has been complemented by experimental studies of fetal development in animal models. These have focussed particularly on fetal brain development because of its obvious importance. Definite effects have been observed in a variety of animal models — the rat, the marmoset and the sheep. In addition studies of the mechanisms involved have been carried out which have revealed the importance of maternal thyroid function for fetal brain development.


Iodine Deficiency Iodine Deficiency Disorder Fetal Sheep Iodine Deficiency Disorder Spastic Diplegia 
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  1. 1.
    Hetzel, B.S. Iodine Deficiency Disorders (IDD) and their Eradication. Lancet 2:1126–1129 (1983)PubMedCrossRefGoogle Scholar
  2. 2.
    Dobbing, J. The later development of the brain and its vulnerability, in; “Scientific Foundations of Paediatrics”, J.A. Davis and J. Dobbing, eds. Heinemann Medical, London (1974) pp. 565–577Google Scholar
  3. 3.
    Mano, M.T., Potter, B.J., Belling, G.B. and Hetzel, B.S. Low-iodine diet for the production of severe I deficiency in marmosets (Callithrix jacchus jacchus). Brit. J. Nutrition 54: 367–372 (1985)CrossRefGoogle Scholar
  4. 4.
    Potter, B.J., Jones, G.B., Buckley, R.A., Belling, G.B., Mcintosh, G.H. and Hetzel, B.S. Production of Severe Iodine Deficiency in Sheep using a prepared Low-iodine Diet. Aust. J. Biol. Sci. 33: 53–61 (1980)PubMedGoogle Scholar
  5. 5.
    Mano, M.T., Potter, B.J., Belling, G.B., Chavadej, J. and Hetzel, B.S. Fetal brain development in response to iodine deficiency in a primate model (Callithrix jacchus jacchus). J. Neurological Sciences 79: 287–300 (1987)CrossRefGoogle Scholar
  6. 6.
    Fisher, D.A., Dussault, J.H., Erenberg,A. and Lam, R.W. Thyroxine and triiodothyronine metabolism in maternal and fetal sheep. Pediatric Research12: 894 – 899 (1972)Google Scholar
  7. 7.
    Potter, B.J., Mano, M.T., Belling,G.B., Mcintosh, G.H., Hua, C., Cragg, B.G., Marshall, J., Wellby, M.L. and Hetzel, B.S. Retarded fetal brain development resulting from severe dietary iodine deficiency in sheep. Neuropath, appl. Neurobiology 8: 303–313 (1982)CrossRefGoogle Scholar
  8. 8.
    Hetzel, B.S. and Potter, B.J. Iodine deficiency and the role of thyroid hormones in brain development, in: “Neurobiology of the Trace Elements” I. Dreosti and R.M. Smith. Humana Press, New Jersey (1983) pp. 83 – 133CrossRefGoogle Scholar
  9. 9.
    Potter, B.J., Mano, M.T., Belling, G.B., Martin, D.M., Cragg, B.G., Chavadej, J. and Hetzel, B.S. Restoration of Brain Growth in Fetal Sheep after Iodized Oil Administration to Pregnant Iodine-deficient Ewes. J. Neurological Sci. 66: 15–26 (1984)CrossRefGoogle Scholar
  10. 10.
    Mcintosh, G.H., Baghurst, K.I., Potter, B.J., Hetzel, B.S. Fetal thyroidectomy and brain development in the sheep. Neuropath. Appl. Neurobiol. 5: 103–114 (1979)CrossRefGoogle Scholar
  11. 11.
    Mcintosh, G.H., Potter, B.J., Hetzel, B.S., Hua, C.H., Cragg, B.G. The effects of 98 day fetal thyroidectomy on brain development in the sheep. J. Comp. Path. 92: 5991–607 (1982)CrossRefGoogle Scholar
  12. 12.
    Mcintosh, G.H., Potter,B.J., Mano, M.T., Hua, C.H., Cragg, B.G. and Hetzel, B.S. The effect of maternal and fetal thyroidectomy on fetal brain development in the sheep. Neuropath. Appl. Neurobiol. 9: 215–223 (1983)CrossRefGoogle Scholar
  13. 13.
    Potter, B.J., Mcintosh, G.H. and Hetzel, B.S. The effect of iodine deficiency on fetal brain development in sheep, in: “Fetal Brain Disorders - Recent Approaches to the Problem of Mental Deficiency” B.S. Hetzel and R.M. Smith Eds. Elsevier, Amsterdam (1981) pp.119–148Google Scholar
  14. 14.
    Erenberg, A. and Fisher, D.A. Thyroid hormone metabolism in the fetus, in: “Fetal and Neonatal Physiology” R.S. Comline, K. W. Cross, G.S. Dawes and P.W. Nathanielsz eds. Cambridge University Press, Cambridge (1973) pp. 508–526Google Scholar
  15. 15.
    Thorburn, G.D. and Hopkins, P.S. Thyroid function in the fetal lamb, in: “Fetal and Neonatal Physiology”,R.S. Comline, K.W. Cross, G.S. Dawes and P.W. Nathanielsz eds. Cambridge University Press, Cambridge (1973) pp. 488–507Google Scholar
  16. 16.
    Fisher, D.A., Dussault, J.H., Sack, J. and Chopra, I.J. Ontogenesis of hypothalamic pituitary thyroid function and metabolism in man, sheep and rat. Rec. Prog. Horm. Res. 33: 593–116 (1977)Google Scholar
  17. 17.
    Osorio, C. and Myant, N.B. The passage of thyroid hormone from mother to fetus and its relation to fetal development. Br. Med. Bull. 16: 159 (1960)PubMedGoogle Scholar
  18. 18.
    Hamburgh, M. The role of thyroid and growth hormone in neurogenesis, in: “Current Topics in Developmental Biology”, J. Moscona and J. Monroy eds. Academic Press, New York (1969) 4: 109Google Scholar
  19. 19.
    Obregon, J., Mallol, R., Pastor, G., Morreale de Escobar and Escobar del Rey, F. L-thyroxine and 3,5,3’-Triiodo-L-Thyronine in Rat Embryos before onset of Fetal Thyroid Function. Endocrinology 114: 305-307 (1984).PubMedCrossRefGoogle Scholar
  20. 20.
    Woods, R.J., Sinha, A.K. and Ekins, R.P. Uptake and metabolism of thyroid hormones by the rat fetus in early pregnancy. Clin. Sci. 67: 359–363 (1984)PubMedGoogle Scholar
  21. Potter, B.J., Mcintosh, G.H., Mano, M.T., Baghurst, P.A., Chavadej, J., Hua, C.H., Cragg, B.G. and Hetzel, B.S. The effect of maternal thyroidectomy prior to conception on fetal brain development in sheep. Acta Endocrinologica 112: 93–99 (1986)PubMedGoogle Scholar
  22. 22.
    Morreale de Escobar, G., Pastor, R., Obregon, M.J. and Escobar Del Rey, F. Effects of maternal hypothyroidism on weight and thyroid hormone content of rat embryonic tissues,before and after onset of fetal thyroid function. Endocrinology117: 1890 – 1900 (1985)PubMedCrossRefGoogle Scholar
  23. 23.
    DeLong, R. Neurological involvement in iodine deficiency disorders, in: “The Prevention and Control of Iodine Deficiency Disorders”, B.S. Hetzel, J.T. Dunn and B.S. Stanbury eds. Elsevier, Amsterdam (1987) pp. 49–63Google Scholar
  24. 24.
    Pharoah, P.O.D. Epidemiological studies of endemic cretinism in the Jimi River Valley in New Guinea, in: “Endemic cretinism”, B.S. Hetzel and P.O.D. Pharoah eds, Papua New Guinea Institute of Human Biology Monograph Series (1971) 2: 109–116Google Scholar
  25. 25.
    Hetzel, B.S. and Hay, I.D. Thyroid function, iodine nutrition and fetal brain development. CI. Endo. 11: 445–460 (1979)CrossRefGoogle Scholar
  26. 26.
    Pharoah, P.O.D., Connolly, K.J., Hetzel, B.S. and Ekins, R.P. Maternal thyroid function and motor competence in the child. Develop. Med, and Child Neurology 23: 76–82 (1981)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Basil S. Hetzel
    • 1
  • Mark L. Mano
    • 1
  • J. Chevadev
    • 2
    • 3
  1. 1.Division of Human NutritionCSIROAdelaideAustralia
  2. 2.Dept. PhysiologyMonash UniversityClayton, Vic.Australia
  3. 3.Dept. AnatomyMahidol UniversityBangkokThailand

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