Dopamine Receptors And Signal Transduction

  • R. G. MacKenzie
  • J. W. Kebabian


Dopamine receptors can be (and have been) identified on the basis of behavioral or physiological responses (such as turning behavior, supression of prolactin release or renal vasodilatation). However, by studying the signal transduction mechanisms used by the dopamine receptors, especially valuable insight into the identification and the classification of these receptors have been gathered. Thus, the dopamine-sensitive adenylate cyclase has proven to be a valuable model of the entity now known as the D-l receptor (Kebabian et al., 1972). Furthermore, the now widely-accepted idea that there are two classes of dopamine receptor was based, in part, on the observation that certain drugs displayed inappropriate activity in the dopamine-sensitive adenylate cyclase assay (Kebabian and Calne, 1979).


Dopamine Receptor Adenylate Cyclase Pertussis Toxin Adenylate Cyclase Activity Prolactin Secretion 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • R. G. MacKenzie
    • 1
  • J. W. Kebabian
    • 1
  1. 1.Abbott LaboratoriesUSA

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