Functional Anatomy of Dopamine Receptors
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The selective degeneration of pigmented dopaminergic neurons of the substantia nigra which results in striatal dopamine (DA) depletion is the critical pathologic process in Parkinson’s disease (PD) (1). The administration of dopaminergic drugs that have access to the central nervous system results in amelioration of the clinical syndrome characteristic of PD (bradykinesia, rigidity and tremor) (2). Dopaminergic drugs reverse the symptoms of PD by interacting with DA receptors principally localized in the striatum. Biochemical studies of brain DA receptors suggest the existence of at least two types. The DA receptor is positively linked to adenylate cyclase while the D2 DA receptor is negatively linked (3). Current evidence suggests that the anti-Parkinson efficacy of dopaminergic drugs is mediated primarily by the D2 receptor (4).
KeywordsGlucose Utilization Dopaminergic Drug Autoradiographic Method Desipramine Hydrochloride Apomorphine Hydrochloride
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