Advertisement

Functional Anatomy of Dopamine Receptors

  • G. Frederick Wooten
  • Joel M. Trugman
Chapter
  • 91 Downloads

Abstract

The selective degeneration of pigmented dopaminergic neurons of the substantia nigra which results in striatal dopamine (DA) depletion is the critical pathologic process in Parkinson’s disease (PD) (1). The administration of dopaminergic drugs that have access to the central nervous system results in amelioration of the clinical syndrome characteristic of PD (bradykinesia, rigidity and tremor) (2). Dopaminergic drugs reverse the symptoms of PD by interacting with DA receptors principally localized in the striatum. Biochemical studies of brain DA receptors suggest the existence of at least two types. The DA receptor is positively linked to adenylate cyclase while the D2 DA receptor is negatively linked (3). Current evidence suggests that the anti-Parkinson efficacy of dopaminergic drugs is mediated primarily by the D2 receptor (4).

Keywords

Glucose Utilization Dopaminergic Drug Autoradiographic Method Desipramine Hydrochloride Apomorphine Hydrochloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hornykiewicz, O. (1982). Brain neurotransmitter changes in Parkinson’s disease. In Movement Disorders, C.D. Marsden and S. Fahn, eds. Butterworths, London, pp. 41–58.Google Scholar
  2. 2.
    Cotzias, G.C., Papavasiliou, P.S., Fehling, C., et al. (1970). Similarities between neurologic effects of L-dopa and of apomorphine. New Engl. J. Med. 282:31–35.PubMedCrossRefGoogle Scholar
  3. 3.
    Stoof, J.C. and Kebabian, J.W. (1984). Two dopamine receptors: biochemistry, physiology, and pharmacology. Life Sci. 35:2281–2296.PubMedCrossRefGoogle Scholar
  4. 4.
    Schachter, M., Bedard, P., Debono, A.G., et al. (1980). The role of D1 and D2 receptors. Nature 286:157–159.PubMedCrossRefGoogle Scholar
  5. 5.
    Ungerstedt, U. (1971). Stereotaxic mapping of monoamine pathways in the rat brain. Acta. Physiol. Scand. (Suppl) 367:1–48.Google Scholar
  6. 6.
    Marshall, J.F., Richardson, J.S., and Teitelbaum, P. (1974). Nigrostriatal bundle damage and the lateral hypothalamic syndrome. J. Comp. Physiol. Psychol. 87:808–830.PubMedCrossRefGoogle Scholar
  7. 7.
    Marshall, J.F. (1978). Sensory inattention by 6-hydroxydopamine injections along the ascending dopaminergic fibers: spontaneous recovery and pharmacological control. Soc. Neurosci. Abstr. 4:46.Google Scholar
  8. 8.
    Sokoloff, L., Reivich, M., Kennedy, C., et al. (1977). The [14C] deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28:879–916.CrossRefGoogle Scholar
  9. 9.
    Mata, M., Fink, D.J., Gainer, H., et al. (1980). Activity-dependent energy metabolism in rat pituitary primarily reflects sodium pump activity. J. Neurochem. 34:213–215.PubMedCrossRefGoogle Scholar
  10. 10.
    Wooten, G.F. and Collins, R.C. (1981). Metabolic effects of unilateral lesion of the substantia nigra. J. Neurosci. 1:285–291.PubMedGoogle Scholar
  11. 11.
    Trugman, J.M. and Wooten, G.F. (1986). The effects of L-DOPA on regional cerebral glucose utilization in rats with unilateral lesions of the substantia nigra. Brain Res. 379:264–274.PubMedCrossRefGoogle Scholar
  12. 12.
    Carpenter, M.B. (1981). Anatomy of the corpus striatum and brain stem integrating mechanisms. In Handbook of Physiology — The Nervous System II, pp. 947–995.Google Scholar
  13. 13.
    Wooten, G.F. (1981). Dopamine neurons control metabolism in the lateral habenular nucleus indirectly via the entopeduncularis. Soc. Neurosci. Abstr. 7:851.Google Scholar
  14. 14.
    Trugman, J.M. and Wooten, G.F (1987). Selective Dl and D2 dopamine agonists differentially alter basal ganglia glucose utilization in rats with unilateral 6-hydroxydopamine substantia nigra lesions. J. Neurosci. 7:2927–2935.PubMedGoogle Scholar
  15. 15.
    Wooten, G.F. and Collins, R.C. (1983). Effects of dopaminergic stimulation on functional brain metabolism in rats with unilateral substantia nigra lesions. Brain Res. 263:267–275.PubMedCrossRefGoogle Scholar
  16. 16.
    Boyson, S.J., McGonigle, P., and Molinoff, I.P.B. (1986). Quantitative autoradiographic localization of the Dl and D2 subtypes of dopamine receptors in rat brain. J. Neurosci. 6:3177–3188.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • G. Frederick Wooten
    • 1
  • Joel M. Trugman
    • 1
  1. 1.Departments of Neurology and NeuroscienceUniversity of Virginia Medical CenterCharlottesvilleUSA

Personalised recommendations