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Architecture Of Cholinergic Pre-And Postsynaptic Markers In The Primate Striatum

  • Deborah C. Mash
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Abstract

The basal ganglia are the critical relay for the extrapyramidal system and the execution of motor function. Marsden has suggested that the basal ganglia are responsible for the automatic execution of learned motor plans (21). The basal ganglia may also play a role in higher cognitive functions. Injury to the basal ganglia is known to produce changes in a variety of behavioral functions in humans and animals including learning, language and personality (4, 32). The degree to which the basal ganglia are involved in cognitive processes is, at present, poorly understood. However, connectional and chemoarchitectural studies have demonstrated that the basal ganglia comprise highly heterogeneous and complex structures which are linked to different neural systems in brain.

Keywords

Basal Ganglion Nucleus Accumbens Muscarinic Receptor Dorsal Striatum Dense Patch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Clarke, P.B.S. and Pert, A. Autoradiographic evidence for nicotine receptors on nigrostratial and mesolimbic dopaminergic neurons. Brain Res. 348:355–358, 1985.PubMedCrossRefGoogle Scholar
  2. Clarke, P.B.S., R.D. Schwartz, S.M. Paul, C.B. Pert, and A. Pfert (1985) Nicotine binding in rat brain: Autoradiographic comparison of [3H]-acetylcholine, [3H]-nicotine, and [125I]-bunagarotoxin. J. Neurosci. 5, 1307–1315.PubMedGoogle Scholar
  3. Crutcher, M.D. and Delong, M.R. Single cell studies of the primate putamen. I. Functional organization. Exp. Brain Res. 53:244–258, 1983.CrossRefGoogle Scholar
  4. Damasio A.R. Language and the basal ganglia. Trends Neurosci. 6:442–444, 1983.CrossRefGoogle Scholar
  5. Flynn, D.D., and D.C. Mash characterization if L-[3H]-nicotine binding in human cerebral cortex: Comparison between Alzheimer’s disease and the normal. J. Neurochem. 47:1948–1954, 1986.PubMedCrossRefGoogle Scholar
  6. Flynn, D.D. and L.T. Potter Effect of solubilization on the distinct binding properties of muscarine receptors from rabbit hippocampus and brainstem. Mol. Pharm. 30:193–199, 1986.Google Scholar
  7. Goldman-Rakic, P.S. Cytoarchitectonic heterogeneity of the primate neostriatum: Subdivisión into island and matric cellular compartments. J. Comp. Neurol. 205:398–413, 1982.PubMedCrossRefGoogle Scholar
  8. Goldman, P.S., Ros wold, H.E., Vest, B. and Galkin, T.W., Analysis of the delayed alternation deficit produced by dorsolateral prefrontal lesions in the monkey. J. Comp. Physiol. Psych. 77:262–280, 1971.CrossRefGoogle Scholar
  9. Graybiel, A.M. Dopamine-containing innervation of the striatum: Subsystems and their striated correspondents. In-Functions of the Basal Ganglia, Ciba Foundations Symposium 107: 114–144, 1984.Google Scholar
  10. Graybiel, A.M. Correspondence between the dopamine islands and striosomes of the mammalian striatum. Neuroscience 13:1157–1187, 1984.PubMedCrossRefGoogle Scholar
  11. Graybiel, A.M., Baughman, R.W. and Eckenstein, F. Cholinergic neuropil of the striatum observes striosomal boundaries. Nature 323:625–627, 1986.PubMedCrossRefGoogle Scholar
  12. Graybiel, A.M. and Ragsdale, C.W. Jr., In-Emson, PC (ed) Chemical Neuronatomy. Raven Press, New York, 427–504.Google Scholar
  13. Gerfen, C.R. The neostriatal mosaic: compartmentalization of corticostriatal input and strionigral output systems. Nature 311:461–464, 1984.PubMedCrossRefGoogle Scholar
  14. Haga, K. and Haga, T. Purification of the muscarinic acetylcholine receptor from porcine brain. J. Biol. Chem. 260:7927–7935, 1885.Google Scholar
  15. Herkenham M, Moon-Edley, and S. Stuart, Cell clusters in the nucleus accumbens in the rat and the mosaic relationship of opiate receptors, acetylcholinesterase and subcortical afferent terminations. Neuroscience 11:561–593, 1984.PubMedCrossRefGoogle Scholar
  16. Johannsen, O. and Hokfelt, T., Thyrotropin releasing hormone, somatostatin, and enkephalin: distribution studies using immunohistochemical techniques. J. Histochem. Cytochem. 28:364–366, 1980.CrossRefGoogle Scholar
  17. Jones, E.G., Coulter, J.D., Burton, H., and Porter, H. Cells of origin and terminal distribution of corticostriatal fibers arising in the sensory-motor cortex of monkeys. J. Comp. Neurol. 173:53–80, 1977.PubMedCrossRefGoogle Scholar
  18. Joyce, J.N., Sapp, D.G. and Marshall, J.F. Human striatal dopamine receptors are organized in compartments. Proc. Natl. Acad. Sci. 83:8002–8006, 1986.PubMedCrossRefGoogle Scholar
  19. Joyce, J.N. and Marshall, J.F., Striatal topography of D-2 receptors correlates with indexes of cholinergic neuron localization. Neurosci. Lett. 53:127–131, 1985.PubMedCrossRefGoogle Scholar
  20. Marsden, C.D. The mysterious motor function of the basal ganglia: The Robert Wartenberg lecture. Neurology 32:514–539, 1982.PubMedGoogle Scholar
  21. Mash, D.C. and Potter, L.T. Autoradiographic localization of Ml and M2 muscarine receptors in the rat brain. Neurosci. 19:551–564, 1986.CrossRefGoogle Scholar
  22. Mash, D.C. and Mesulam, M-M. Muscarine receptor distributions within architectonic subregions of the primate neocortex. Soc. Neurosci, Abstr. 12:809, 1986.Google Scholar
  23. Mash, D.C., White, W.F. and Mesulam, M-M. Distribution of muscarinic receptor subtypes with architectonic sectors of the primate cerebral cortex. J. Comp. Neurol. In Press.Google Scholar
  24. Mesulam, M.-M., Mufson, E.J., Levey, A.I., and Wainer, B.H., Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey. J. Comp. Neurol. 214:170–197, 1983.PubMedCrossRefGoogle Scholar
  25. Mesulam, M.-M., Rosen, A.D. and Mufson, E.J. Regional variations in cortical cholinergic innervation: Chemoarchitectonics of acetylcholinesterase-containing fibers in the macaque brain. Brain Res. 311:245–258, 1984.PubMedCrossRefGoogle Scholar
  26. Mesulam, M.-M., Mufson, E.J., Levey, A.I. and Wainer, B.H. Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Neuroscience 12: 669–686, 1984.PubMedCrossRefGoogle Scholar
  27. Nastuk, M. A. and Graybiel, A.M. Patterns of muscarinic cholinergic binding in the striatum and their relation to the dopamine islands and striosomes. J. Comp. Neurol. 237:176–194, 1985.PubMedCrossRefGoogle Scholar
  28. Nastuk, M.A. and Graybiel, A.M. Autoradiography of Ml and M2 muscarinic receptor binding in the striatum, In-Trends Pharmacol. Sci. (suppl) p. 92, Elsevier, Amsterdam, 1986.Google Scholar
  29. Parent, A., Bouchard, C. and Smith, Y. The striopallidal and striatonigral projections: Two distinct fiber systems in the primate. Brain Res. 303:385–390, 1984.PubMedCrossRefGoogle Scholar
  30. Potter, L.T., Flynn, D.D. Hanchett, H.E., Kalinoski, D.L. Luber-Narod, J.L., and Mash, D.C., Independent Ml and M2 muscarine receptors: Ligands, autoradiography and functions. In-Trends Pharmacol. Sci (suppl) (eds. Hirschowitz and, B.I., Hammer, R., Giachetti, A., Keirns, J., and Levine, R.) pp. 22–31. Elsevier, Amsterdam, 1984.Google Scholar
  31. Richfield, E.K., Twyman, R. Berent, S. Neurological syndrome following bilateral damage to the head of the caudate. Ann. Neurol. 22:768–771, 1987.PubMedCrossRefGoogle Scholar
  32. Rhodes, K.J., Joyce, J.N., Sapp, D. and Marshall J.F. [3H]-Hemicholinium-3 binding in rabbit striatum: correspondence with patchy acetylcholinesterase staining and a method for quantifying striatal compartments. Brain Res. 412:400–404, 1987.PubMedCrossRefGoogle Scholar
  33. Selemon, L.D. and Goldman-Rakic, P.S. Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey. J. Neurosci. 5:776–794, 1985.PubMedGoogle Scholar
  34. Watson, M., T.W. Vickroy, W.R. Roeske, and Yamamura, H.I., Subclassification of muscarinic receptors based upon the selective antagonist pirenzepine. In-Trends the Pharmacol. Sci. (eds. Hirschowitz and, B.I., Hammer, R., Giachetti, A., Keirns, J., and Levine, R.) pp. 9–11 Elsevier, Amsterdam, 1984.Google Scholar
  35. Wolf, N.J. and Butcher LL., Cholinergic neurons in the caudate-putamen complex proper are intrinsically organized: a combined Evans Blue and acetylcholinesterase analysis. Brain Res. Bull., 7:487–507,1981.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Deborah C. Mash
    • 1
  1. 1.Departments of Neurology and PharmacologyUniversity of Miami School of MedicineUSA

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